Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Ferdinand von Meyenn"'
Autor:
Marc Jan Bonder, Stephen J. Clark, Felix Krueger, Siyuan Luo, João Agostinho de Sousa, Aida M. Hashtroud, Thomas M. Stubbs, Anne-Katrien Stark, Steffen Rulands, Oliver Stegle, Wolf Reik, Ferdinand von Meyenn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Ageing is the accumulation of changes and decline of function of organisms over time. The concept and biomarkers of biological age have been established, notably DNA methylation-based clocks. The emergence of single-cell DNA methylation prof
Externí odkaz:
https://doaj.org/article/ad7a8eed3efe49fdb4a325112b626eb9
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-30 (2024)
Abstract Background Single-cell chromatin accessibility assays, such as scATAC-seq, are increasingly employed in individual and joint multi-omic profiling of single cells. As the accumulation of scATAC-seq and multi-omics datasets continue, challenge
Externí odkaz:
https://doaj.org/article/e3f63cfdc24544caac85e2574c53bca2
Autor:
Anna B. Rüegg, Vera A. van der Weijden, João Agostinho de Sousa, Ferdinand von Meyenn, Hubert Pausch, Susanne E. Ulbrich
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Embryonic diapause in mammals is a temporary developmental delay occurring at the blastocyst stage. In contrast to other diapausing species displaying a full arrest, the blastocyst of the European roe deer (Capreolus capreolus) proliferates
Externí odkaz:
https://doaj.org/article/90bfebee37b84561b6fa8390c2f89509
Autor:
Isabel Reinisch, Helene Michenthaler, Alba Sulaj, Elisabeth Moyschewitz, Jelena Krstic, Markus Galhuber, Ruonan Xu, Zina Riahi, Tongtong Wang, Nemanja Vujic, Melina Amor, Riccardo Zenezini Chiozzi, Martin Wabitsch, Dagmar Kolb, Anastasia Georgiadi, Lisa Glawitsch, Ellen Heitzer, Tim J. Schulz, Michael Schupp, Wenfei Sun, Hua Dong, Adhideb Ghosh, Anne Hoffmann, Dagmar Kratky, Laura C. Hinte, Ferdinand von Meyenn, Albert J. R. Heck, Matthias Blüher, Stephan Herzig, Christian Wolfrum, Andreas Prokesch
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract In obesity, sustained adipose tissue (AT) inflammation constitutes a cellular memory that limits the effectiveness of weight loss interventions. Yet, the impact of fasting regimens on the regulation of AT immune infiltration is still elusive
Externí odkaz:
https://doaj.org/article/84abdd4dbbbf4fedab68791a6e68856d
Autor:
Zheng Fan, Mara Karakone, Shunmugam Nagarajan, Nadine Nagy, Wiebke Mildenberger, Ekaterina Petrova, Laura Catharina Hinte, Mitchell Bijnen, Philipp Häne, Eric Nelius, Jing Chen, Irina Ferapontova, Ferdinand von Meyenn, Francesco Trepiccione, Mesut Berber, David Penton Ribas, Anne Eichmann, Maria-Christina Zennaro, Norihiko Takeda, Jens W. Fischer, Ariadni Spyroglou, Martin Reincke, Felix Beuschlein, Johannes Loffing, Melanie Greter, Christian Stockmann
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114395- (2024)
Summary: Macrophages play crucial roles in organ-specific functions and homeostasis. In the adrenal gland, macrophages closely associate with sinusoidal capillaries in the aldosterone-producing zona glomerulosa. We demonstrate that macrophages preser
Externí odkaz:
https://doaj.org/article/02b69b219d364673aaf81f6bfedf2bb0
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101923- (2024)
Objectives: We have previously shown that lactate is an essential metabolite for macrophage polarisation during ischemia-induced muscle regeneration. Recent in vitro work has implicated histone lactylation, a direct derivative of lactate, in macropha
Externí odkaz:
https://doaj.org/article/287e519043c34a03a1f37341da88e588
Autor:
Yu-Te Yeh, Chandan Sona, Xin Yan, Yunxiao Li, Adrija Pathak, Mark I. McDermott, Zhigang Xie, Liangwen Liu, Anoop Arunagiri, Yuting Wang, Amaury Cazenave-Gassiot, Adhideb Ghosh, Ferdinand von Meyenn, Sivarajan Kumarasamy, Sonia M. Najjar, Shiqi Jia, Markus R. Wenk, Alexis Traynor-Kaplan, Peter Arvan, Sebastian Barg, Vytas A. Bankaitis, Matthew N. Poy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns) 4-OH kina
Externí odkaz:
https://doaj.org/article/07e41593908f4d84a89d335f3da86332
Autor:
Eva Galle, Chee-Wai Wong, Adhideb Ghosh, Thibaut Desgeorges, Kate Melrose, Laura C. Hinte, Daniel Castellano-Castillo, Magdalena Engl, Joao Agostinho de Sousa, Francisco Javier Ruiz-Ojeda, Katrien De Bock, Jonatan R. Ruiz, Ferdinand von Meyenn
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-28 (2022)
Abstract Background Histone lactylation has been recently described as a novel histone post-translational modification linking cellular metabolism to epigenetic regulation. Results Given the expected relevance of this modification and current limited
Externí odkaz:
https://doaj.org/article/c9ecdc1a92de4e0786206a8879e43b67
Autor:
Sarah Greve, Gisela A. Kuhn, Mara D. Saenz-de-Juano, Adhideb Ghosh, Ferdinand von Meyenn, Katrin Giller
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Scientific evidence suggests that not only murine scent communication is regulated by major urinary proteins, but that their expression may also vary in response to metabolism via a yet unknown mechanism. Major urinary proteins are expressed
Externí odkaz:
https://doaj.org/article/9211759c215049f8a07ae8652f75a5f5
Autor:
Lukas M. von Ziegler, Amalia Floriou-Servou, Rebecca Waag, Rebecca R. Das Gupta, Oliver Sturman, Katharina Gapp, Christina A. Maat, Tobias Kockmann, Han-Yu Lin, Sian N. Duss, Mattia Privitera, Laura Hinte, Ferdinand von Meyenn, Hanns U. Zeilhofer, Pierre-Luc Germain, Johannes Bohacek
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Acute stress can help individuals to respond to challenging events, although chronic stress leads to maladaptive changes. Here, the authors present a multi omic analysis profiling acute stress-induced changes in the mouse hippocampus, providing a res
Externí odkaz:
https://doaj.org/article/859e65c14b6146b5b795319376098f0e