Výsledky vyhledávání - "Ferdinand Molnár"

Akademický článek

DTA Atlas: A massive-scale drug repurposing database

Autor: Madina Sultanova, Elizaveta Vinogradova, Alisher Amantay, Ferdinand Molnár, Siamac Fazli

Publikováno v: Artificial Intelligence in the Life Sciences, Vol 6, Iss , Pp 100115- (2024)

The drug development process is costly and time-consuming. Repurposing existing approved drugs, an efficient and cost-effective strategy, involves assessing numerous drug-protein pairs to uncover new interactions. While modern in silico methods enhan

Externí odkaz: https://doaj.org/article/08cc79105f91450aa2fc2b137585548c

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Akademický článek

Enhancing an Oxidative 'Trojan Horse' Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside

Autor: Agata N. Burska, Bayansulu Ilyassova, Aruzhan Dildabek, Medina Khamijan, Dinara Begimbetova, Ferdinand Molnár, Dos D. Sarbassov

Publikováno v: Cells, Vol 11, Iss 21, p 3454 (2022)

The turn-on mutations of the KRAS gene, coding a small GTPase coupling growth factor signaling, are contributing to nearly 25% of all human cancers, leading to highly malignant tumors with poor outcomes. Targeting of oncogenic KRAS remains a most cha

Externí odkaz: https://doaj.org/article/63c40894e1334db2ad76639131414761

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Akademický článek

A Vitamin D Receptor Selectively Activated by Gemini Analogs Reveals Ligand Dependent and Independent Effects

Autor: Tiphaine Huet, Gilles Laverny, Fabrice Ciesielski, Ferdinand Molnár, Thanuja Gali Ramamoorthy, Anna Y. Belorusova, Pierre Antony, Noelle Potier, Daniel Metzger, Dino Moras, Natacha Rochel

Publikováno v: Cell Reports, Vol 10, Iss 4, Pp 516-526 (2015)

The bioactive form of vitamin D [1,25(OH)2D3] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR). The 3D structures of the VDR ligand-binding dom

Externí odkaz: https://doaj.org/article/c1ca4632498449e98f431812cd05e383

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Akademický článek

1α,25(OH)2-3-epi-vitamin D3, a natural physiological metabolite of vitamin D3: its synthesis, biological activity and crystal structure with its receptor.

Autor: Ferdinand Molnár, Rita Sigüeiro, Yoshiteru Sato, Clarisse Araujo, Inge Schuster, Pierre Antony, Jean Peluso, Christian Muller, Antonio Mouriño, Dino Moras, Natacha Rochel

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e18124 (2011)

BackgroundThe 1α,25-dihydroxy-3-epi-vitamin-D3 (1α,25(OH)2-3-epi-D3), a natural metabolite of the seco-steroid vitamin D3, exerts its biological activity through binding to its cognate vitamin D nuclear receptor (VDR), a ligand dependent transcript

Externí odkaz: https://doaj.org/article/25a28b670f684904a71dbf40fb88d15a

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