Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ferah Yildirim"'
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Huntington’s disease (HD) is a chronic neurodegenerative disorder caused by an expansion of polyglutamine repeats in exon 1 of the Huntingtin gene. Transcriptional dysregulation accompanied by epigenetic alterations is an early and central disease
Externí odkaz:
https://doaj.org/article/fa66b059ff204c45947fd7f64afccce6
Autor:
Katharina Hecklau, Susanne Mueller, Stefan Paul Koch, Mustafa Hussain Mehkary, Busra Kilic, Christoph Harms, Philipp Boehm-Sturm, Ferah Yildirim
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease characterized by a late clinical onset of psychiatric, cognitive, and motor symptoms. Transcriptional dysregulation is an early and central disease mechanism which is acco
Externí odkaz:
https://doaj.org/article/f9766f01a40d417fa1324980494d2886
Autor:
Ferah Yildirim, Shengbo Ji, Golo Kronenberg, Angel Barco, Roman Olivares, Eva Benito, Ulrich Dirnagl, Karen Gertz, Matthias Endres, Christoph Harms, Andreas Meisel
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95465 (2014)
Epigenetic transcriptional regulation by histone acetylation depends on the balance between histone acetyltransferase (HAT) and deacetylase activities (HDAC). Inhibition of HDAC activity provides neuroprotection, indicating that the outcome of cerebr
Externí odkaz:
https://doaj.org/article/1f6f8dd99ca047e787aa4be7bd4247ac
Autor:
Gerard R. Hall, Philipp Boehm-Sturm, Ulrich Dirnagl, Carsten Finke, Marco Foddis, Christoph Harms, Stefan Paul Koch, Joseph Kuchling, Christopher R. Madan, Susanne Mueller, Celeste Sassi, Stamatios N. Sotiropoulos, Rebecca C. Trueman, Marcus D. Wallis, Ferah Yildirim, Tracy D. Farr
Publikováno v:
Stroke 53(5), 1735-1745 (2022). doi:10.1161/STROKEAHA.121.036997
Background: Connectome analysis of neuroimaging data is a rapidly expanding field that offers the potential to diagnose, characterize, and predict neurological disease. Animal models provide insight into biological mechanisms that underpin disease, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409df5c4dd97591628cb1e62574f88f6
https://pubmed.ncbi.nlm.nih.gov/35105183
https://pubmed.ncbi.nlm.nih.gov/35105183
Autor:
Gonca Bayraktar, Oliver Stork, Ferah Yildirim, Guilherme M. Gomes, Anna Karpova, Shoji Tajima, Michael R. Kreutz, PingAn Yuanxiang, Alessandro D. Confettura, Syed Ahsan Raza, Isao Suetake
Publikováno v:
Neuropsychopharmacology
Neuropsychopharmacology, 45(12):2120-2130
Neuropsychopharmacology 45(12), 2120-2130 (2020). doi:10.1038/s41386-020-0780-2
Neuropsychopharmacology, 45(12):2120-2130
Neuropsychopharmacology 45(12), 2120-2130 (2020). doi:10.1038/s41386-020-0780-2
DNA methylation is a crucial epigenetic mark for activity-dependent gene expression in neurons. Very little is known about how synaptic signals impact promoter methylation in neuronal nuclei. In this study we show that protein levels of the principal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a4662ed6d1c9118e0c68bd5ed040b9
Autor:
Ferah Yildirim, Ernest Fraenkel, Jocelyne Caboche, Peter Vanhoutte, Victoria Stivanello, Siobhan K. Rigby, Tobias Ehrenberger, Anthony R. Soltis, Christopher W. Ng, Vincent Kappes, Theresa A. Gipson, David E. Housman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (49), pp.24840-24851. ⟨10.1073/pnas.1908113116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, pp.201908113. ⟨10.1073/pnas.1908113116⟩
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (49), pp.24840-24851. ⟨10.1073/pnas.1908113116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (49), pp.24840-24851. ⟨10.1073/pnas.1908113116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, pp.201908113. ⟨10.1073/pnas.1908113116⟩
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (49), pp.24840-24851. ⟨10.1073/pnas.1908113116⟩
Huntington’s disease (HD) is a chronic neurodegenerative disorder characterized by a late clinical onset despite ubiquitous expression of the mutant Huntingtin gene ( HTT ) from birth. Transcriptional dysregulation is a pivotal feature of HD. Yet,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1425976eb098c2f0a0f48bd799e302
https://doi.org/10.1073/pnas.1908113116
https://doi.org/10.1073/pnas.1908113116
Autor:
Gökçe Senger, Ferah Yildirim, Foteini Paraskevopoulou, Poorya Parvizi, Nurcan Tuncbag, Christian Rosenmund
Publikováno v:
Proc Natl Acad Sci U S A
Transcriptional dysregulation in Huntington’s disease (HD) causes functional deficits in striatal neurons. Here, we performed Patch-sequencing (Patch-seq) in an in vitro HD model to investigate the effects of mutant Huntingtin (Htt) on synaptic tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0659d85ad0794e5c4c3021154ae2c7a3
https://doi.org/10.1073/pnas.2020293118
https://doi.org/10.1073/pnas.2020293118
Autor:
Michael Yim, Kyle B. Fischer, Anne C. Smith, Ann M. Graybiel, Theresa A. Gipson, David E. Housman, Ferah Yildirim, Jill R. Crittenden, Hilary A. Bowden
Publikováno v:
Eur J Neurosci
Disruptive or excessive repetitive motor patterns (stereotypies) are cardinal symptoms in numerous neuropsychiatric disorders. Stereotypies are also evoked by psychomotor stimulants such as amphetamine. The acquisition of motor sequences is parallele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fcebbec0159e647746e9470286403bf
https://europepmc.org/articles/PMC8330602/
https://europepmc.org/articles/PMC8330602/
Autor:
Anne C. Smith, David E. Housman, Ann M. Graybiel, Kyle B. Fischer, Jill R. Crittenden, Hilary A. Bowden, Michael Yim, Theresa A. Gipson, Ferah Yildirim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fb77734171d1ccf786357ae5274b942
https://doi.org/10.1111/ejn.15116/v2/response1
https://doi.org/10.1111/ejn.15116/v2/response1
Autor:
Marco Foddis, Stefan Koch, Christopher R. Madan, Stamatios N. Sotiropoulos, Rebecca C. Trueman, Ferah Yildirim, Joseph Kuchling, Tracy D. Farr, Philipp Boehm-Sturm, Celeste Sassi, Marcus D Wallis, Susanne Mueller, Gerard R Hall, Carsten Finke, Christoph Harms, Ulrich Dirnagl
Connectome analysis of neuroimaging data is a rapidly expanding field to identify disease specific biomarkers. Structural diffusion MRI connectivity has been useful in individuals with radiological features of small vessel disease, such as white matt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21f46887b7a348b429d8fa2abf554a40
https://doi.org/10.1101/2020.11.04.366294
https://doi.org/10.1101/2020.11.04.366294