Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle

Autor: Hingst, Janne R., Bruhn, Lea, Hansen, Mads B., Rosschou, Marie F., Birk, Jesper B., Fentz, Joachim, Foretz, Marc, Viollet, Benoit, Sakamoto, Kei, Færgeman, Nils J., Havelund, Jesper F., Parker, Benjamin L., James, David E., Kiens, Bente, Richter, Erik A., Jensen, Jørgen, Wojtaszewski, Jørgen F.P.

Publikováno v: In Molecular Metabolism October 2018 16:24-34

Inducible deletion of skeletal muscle AMPKα 1 reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

Autor: Hingst, Janne Rasmuss, Kjøbsted, Rasmus, Birk, Jesper Bratz, Jørgensen, Nicolas Oldenburg, Larsen, Magnus Romme, Kido, Kohei, Larsen, Jeppe Kjærgaard, Kjeldsen, Sasha Alexandra Sampson, Fentz, Joachim, Frøsig, Christian, Holm, Stephanie, Fritzen, Andreas Mæchel, Dohlmann, Tine Lovsø, Larsen, Steen, Foretz, Marc, Viollet, Benoit, Schjerling, Peter, Overby, Peter, Halling, Jens Frey, Pilegaard, Henriette, Hellsten, Ylva, Wojtaszewski, Jørgen

Publikováno v: Hingst, J R, Kjøbsted, R, Birk, J B, Jørgensen, N O, Larsen, M R, Kido, K, Larsen, J K, Kjeldsen, S A S, Fentz, J, Frøsig, C, Holm, S, Fritzen, A M, Dohlmann, T L, Larsen, S, Foretz, M, Viollet, B, Schjerling, P, Overby, P, Halling, J F, Pilegaard, H, Hellsten, Y & Wojtaszewski, J 2020, ' Inducible deletion of skeletal muscle AMPKα 1 reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise ', Molecular Metabolism, vol. 40, 101028 . https://doi.org/10.1016/j.molmet.2020.101028

Objective: Current evidence for AMPK-mediated regulation of skeletal muscle metabolism during exercise is mainly based on transgenic mouse models with chronic (lifelong) disruption of AMPK function. Findings based on such models are potentially biase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2751::1380e3d4cddc68f26ed2d5707c143ce7
https://curis.ku.dk/portal/da/publications/inducible-deletion-of-skeletal-muscle-ampk-1-reveals-that-ampk-is-required-for-nucleotide-balance-but-dispensable-for-muscle-glucose-uptake-and-fat-oxidation-during-exercise(be35a7f4-2450-4162-80db-f6e514d499e5).html

AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity

Autor: Lantier, Louise, Fentz, Joachim, Mounier, Rémi, Leclerc, Jocelyne, Treebak, Jonas, Pehmøller, Christian, Sanz, Nieves, Sakakibara, Iori, Saint-Amand, Emmanuelle, Rimbaud, Stéphanie, Maire, Pascal, Marette, André, Ventura-Clapier, Renée, Ferry, Arnaud, Wojtaszewski, Jørgen, Foretz, Marc, Viollet, Benoit

Publikováno v: FASEB Journal
FASEB Journal, 2014, 28 (7), pp.3211-24. ⟨10.1096/fj.14-250449⟩

International audience; : AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that plays a central role in skeletal muscle metabolism. We used skeletal muscle-specific AMPKα1α2 double-knockout (mdKO) mice to provide direct gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::643f9d0a35a3c968aa3106e181354d1c
https://doi.org/10.1096/fj.14-250449

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.