The Impact of Nanobody Density on the Targeting Efficiency of PEGylated Liposomes.

Autor: Mesquita, Bárbara S.¹ (AUTHOR), Fens, Marcel H. A. M.¹ (AUTHOR), Di Maggio, Alessia² (AUTHOR), Bosman, Esmeralda D. C.¹ (AUTHOR), Hennink, Wim E.¹ (AUTHOR), Heger, Michal^1,3,4 (AUTHOR) m.heger@uu.nl, Oliveira, Sabrina^1,2 (AUTHOR) m.heger@uu.nl

Publikováno v: International Journal of Molecular Sciences. Dec2022, Vol. 23 Issue 23, p14974. 19p.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

EGFR-Targeted Nanobody Functionalized Polymeric Micelles Loaded with mTHPC for Selective Photodynamic Therapy

Autor: Liu, Yanna, Scrivano, Luca, Peterson, Julia Denise, Fens, Marcel H A M, Beltrán Hernández, Irati, Mesquita, Bárbara, Sastre Torano, Javier, Hennink, Wim E, van Nostrum, Cornelus F, Oliveira, Sabrina, Pharmaceutics, Chemical Biology and Drug Discovery, Celbiologie, Afd Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Afd Chemical Biology and Drug Discovery, Sub Cell Biology

Publikováno v: Molecular Pharmaceutics
Molecular Pharmaceutics. American Chemical Society

meta-Tetra(hydroxyphenyl)chlorin (mTHPC) is one of the most potent second-generation photosensitizers, clinically used for photodynamic therapy (PDT) of head and neck squamous cell carcinomas. However, improvements are still required concerning its p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41edbc36a112a1ce41eb2715c407d335
https://doi.org/10.1021/acs.molpharmaceut.9b01280

Targeting of promising transmembrane proteins for diagnosis and treatment of pancreatic ductal adenocarcinoma

Autor: Mashayekhi, Vida, Mocellin, Orsola, Fens, Marcel H A M, Krijger, Gerard C, Brosens, Lodewijk A A, Oliveira, Sabrina, Sub Cell Biology, Afd Pharmaceutics, Pharmaceutics, Celbiologie

Publikováno v: Theranostics, 11, 9022-9037
Theranostics, 11, 18, pp. 9022-9037
Theranostics, 11(18), 9022. Ivyspring International Publisher
Theranostics

Contains fulltext : 245239.pdf (Publisher’s version ) (Open Access) Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal types of cancer due to the relatively late diagnosis and the limited therapeutic options. Current treatment regimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6562ec08d5c90027c134d441ff9ac9
http://hdl.handle.net/2066/245239

Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model

Autor: Varela-Moreira, Aida, van Straten, Demian, van Leur, Heleen F, Ruiter, Ruud W J, Deshantri, Anil K, Hennink, Wim E, Fens, Marcel H A M, Groen, Richard W J, Schiffelers, Raymond M, Afd Pharmaceutics, Dep Farmaceutische wetenschappen, Pharmaceutics

Publikováno v: International Journal of Pharmaceutics: X, 2. Elsevier BV
Varela-Moreira, A, van Straten, D, van Leur, H F, Ruiter, R W J, Deshantri, A K, Hennink, W E, Fens, M H A M, Groen, R W J & Schiffelers, R M 2020, ' Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model ', International Journal of Pharmaceutics: X, vol. 2, 100049 . https://doi.org/10.1016/j.ijpx.2020.100049
International Journal of Pharmaceutics: X, 2:100049. Elsevier BV
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X, Vol 2, Iss, Pp 100049-(2020)

Carfilzomib-loaded polymeric micelles (CFZ-PM) based on poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) were prepared with the aim to improve the maximum tolerated dose of carfilzomib in a “humanized” bone ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403309a962d9c58f49094d9a26f7afb7
https://dspace.library.uu.nl/handle/1874/411687