Výsledky vyhledávání - "Fengtian, Xue"

Akademický článek

SARS-CoV-2 ORF3a Protein as a Therapeutic Target against COVID-19 and Long-Term Post-Infection Effects

Autor: Jiantao Zhang, Kellie Hom, Chenyu Zhang, Mohamed Nasr, Volodymyr Gerzanich, Yanjin Zhang, Qiyi Tang, Fengtian Xue, J. Marc Simard, Richard Y. Zhao

Publikováno v: Pathogens, Vol 13, Iss 1, p 75 (2024)

The COVID-19 pandemic caused by SARS-CoV-2 has posed unparalleled challenges due to its rapid transmission, ability to mutate, high mortality and morbidity, and enduring health complications. Vaccines have exhibited effectiveness, but their efficacy

Externí odkaz: https://doaj.org/article/2064859716c941f99d4567ae8e898eb7

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Akademický článek

Targeting CAR and Nrf2 improves cyclophosphamide bioactivation while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment

Autor: Sydney Stern, Dongdong Liang, Linhao Li, Ritika Kurian, Caitlin Lynch, Srilatha Sakamuru, Scott Heyward, Junran Zhang, Kafayat Ajoke Kareem, Young Wook Chun, Ruili Huang, Menghang Xia, Charles C. Hong, Fengtian Xue, Hongbing Wang

Publikováno v: JCI Insight, Vol 7, Iss 12 (2022)

Cyclophosphamide (CPA) and doxorubicin (DOX) are key components of chemotherapy for triple-negative breast cancer (TNBC), although suboptimal outcomes are commonly associated with drug resistance and/or intolerable side effects. Through an approach c

Externí odkaz: https://doaj.org/article/1a8ce16626d14dd984fe688ea0acc24d

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Akademický článek

Recombinant Production of Biliverdin IXβ and δ Isomers in the T7 Promoter Compatible Escherichia coli Nissle

Autor: Elizabeth A. Robinson, Nicole Frankenberg-Dinkel, Fengtian Xue, Angela Wilks

Publikováno v: Frontiers in Microbiology, Vol 12 (2021)

The ability to obtain purified biliverdin IX (BVIX) isomers other than the commercially available BVIXα is limited due to the low yields obtained by the chemical coupled oxidation of heme. Chemical oxidation requires toxic chemicals, has very poor B

Externí odkaz: https://doaj.org/article/07e7d00198a243bdb1ea7bae2ff5fabe

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Akademický článek

Improving Drug Sensitivity of HIV-1 Protease Inhibitors by Restriction of Cellular Efflux System in a Fission Yeast Model

Autor: Jiantao Zhang, Qi Li, Shigehiro A. Kawashima, Mohamed Nasr, Fengtian Xue, Richard Y. Zhao

Publikováno v: Pathogens, Vol 11, Iss 7, p 804 (2022)

Fission yeast can be used as a cell-based system for high-throughput drug screening. However, higher drug concentrations are often needed to achieve the same effect as in mammalian cells. Our goal here was to improve drug sensitivity so reduced drugs

Externí odkaz: https://doaj.org/article/10bb9903a934457f95b5050111a5a3db

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Akademický článek

55484 Dual activation of CAR and Nrf2 improves the efficacy: toxicity ratio of cyclophosphamide and doxorubicin-based treatment of TNBC

Autor: Sydney Stern, Dongdong Liang, Linhao Li, Ritika Kurian, Caitlin Lynch, Scott Heyward, Ajoke Kareem, Young Chun, Charles Hong, Fengtian Xue, Hongbing Wang

Publikováno v: Journal of Clinical and Translational Science, Vol 5, Pp 98-98 (2021)

ABSTRACT IMPACT: Triple negative breast cancer (TNBC) affects 10-20% of women with breast cancer and is biologically more aggressive than other subtypes. The novel compound we have developed, DL7076, would give clinicians a vital strategy to improve

Externí odkaz: https://doaj.org/article/eff90bbab36e49628ea8e6aba041e053

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Supplementary figures from Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non–Small Cell Lung Cancers

Autor: Lani F. Wu, Steven J. Altschuler, John D. Minna, Leandro Cerchietti, Fengtian Xue, Kimberley Avila, Long Shan Li, Rossella Marullo, Patrick D. Dospoy, Jill E. Larsen, Satwik Rajaram, Dhruba Deb

This file shows all the supplementary figures as follows: Supplementary Figure 1: Clonal variability introduced by the TP53, KRAS, and MYC manipulations Supplementary Figure 2: Quantitation of signaling alterations for beta-CATENIN, P65, FOXO1 and p-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a31fea4fc79d46ed494599cabd9e0d3
https://doi.org/10.1158/0008-5472.22413797

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Data from Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non–Small Cell Lung Cancers

Oncogene-specific changes in cellular signaling have been widely observed in lung cancer. Here, we investigated how these alterations could affect signaling heterogeneity and suggest novel therapeutic strategies. We compared signaling changes across

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::836897c1cf28d1aabaf239e3ceb0df40
https://doi.org/10.1158/0008-5472.c.6508820.v1

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A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase

Autor: Jingjing Ruan, Dongdong Liang, Wenjing Yan, Yongwang Zhong, Daniel C. Talley, Ganesha Rai, Dingyin Tao, Christopher A. LeClair, Anton Simeonov, Yinghua Zhang, Feihu Chen, Nancy L. Quinney, Susan E. Boyles, Deborah M. Cholon, Martina Gentzsch, Mark J. Henderson, Fengtian Xue, Shengyun Fang

Publikováno v: Molecular biology of the cell. 33(13)

RNF5 has multiple biological roles and has been linked to the development of severe diseases such as cystic fibrosis, acute myeloid leukemia, and certain viral infections. This study developed a small molecule inhibitor and degrader of the RNF5 ubiqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a940a76247f973dab21cfd16e9778c6f
https://pubmed.ncbi.nlm.nih.gov/36074076

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