Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Fengmei Hua"'
Publikováno v:
Journal of International Medical Research, Vol 52 (2024)
Objective This study aimed to assess the reliability of the spot urine protein/creatinine (sP/Cr) ratio for evaluating proteinuria across different ranges and renal functions. Methods In this retrospective study, we analyzed 24-hour urine protein exc
Externí odkaz:
https://doaj.org/article/20d1a78772014c9a8fefef1baefbd623
Publikováno v:
Journal of International Medical Research, Vol 52 (2024)
The penetration of a peritoneal dialysis catheter into the intestinal cavity is a clinically rare complication. In the present retrospective clinical case series, 11 patients with uraemia who received continuous ambulatory peritoneal dialysis and att
Externí odkaz:
https://doaj.org/article/516e82d36e054e9195fb031d408a5735
Autor:
Barbara A. Schweitzer, Atli Thorarensen, Michael S. Davies, Steve R. Turner, Matthew James Pelc, James R. Kiefer, Brenda L. Case, Christie L. Funckes-Shippy, Jacqueline E. Day, Fengmei Hua, Dice Tom, William M. Abraham, Bradley E. Neal, John I. Trujillo, Joseph B. Moon, Blake Tanisha Danielle Rowe, Wei Huang, Craig D. Wegner, Dean Welsch, Chris P. Carron, Anup Zutshi, Bruce C. Hamper, Chad J. Warren, Rhonda S. Woerndle, Christine M. Kornmeier, Vickie M. Dilworth, Melanie L. Williams, Martin E. Dowty, Olson Kirk Lang, Melissa R. Radabaugh, Becky L. Hood, Jerry Z. Yang, Douglas C. Rohrer, Gina M. Jerome, Christine P. Bono
Publikováno v:
ACS Medicinal Chemistry Letters. 1:59-63
Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH2 into PGD2, a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6559b7ee90a239bc2255e65f4dd700
https://doi.org/10.1021/ml900025z
https://doi.org/10.1021/ml900025z
Autor:
Yurong Lai, Meng Li, Fengmei Hua, Yi Zheng, Na Li, Haodan Yuan, Archie Thurston, Joanne Wang, Mike Baratta, Guotao Song
Publikováno v:
European Journal of Pharmaceutical Sciences. 35:114-126
The large interspecies differences of hepatobiliary transport present a challenge for the allometric prediction of human biliary excretion for drug candidates primarily cleared via hepatobiliary secretion. In the present study, we determined the meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a44027550ffe34f232eabad4734e57
https://doi.org/10.1016/j.ejps.2008.06.008
https://doi.org/10.1016/j.ejps.2008.06.008
Autor:
Leslie Z. Benet, Fengmei Hua, Charles G. Knutson, Mark P. Grillo, Kristi L. March, Joseph A. Ware
Publikováno v:
Chemical Research in Toxicology. 21:1933-1938
Diclofenac, a nonsteroidal antiinflammatory drug, is known to be metabolized to chemically reactive intermediates that transacylate GSH forming diclofenac-S-acyl-glutathione (D-SG) in vivo in rat and in vitro in rat and human hepatocytes. Recently, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f613f9cd50871b77faa461a3556f590
https://doi.org/10.1021/tx800073p
https://doi.org/10.1021/tx800073p
Autor:
Fengmei Hua, Mark P. Grillo
Publikováno v:
Chemical Research in Toxicology. 21:1749-1759
Ibuprofen is metabolized to chemically reactive ibuprofen-1- O-acyl-glucuronide (I-1- O-G) and ibuprofen- S-acyl-CoA (I-CoA) derivatives, which are proposed to mediate the formation of drug-protein adducts via the transacylation of protein nucleophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1643f331afe52698fffd694cc6e8f8f9
https://doi.org/10.1021/tx800098h
https://doi.org/10.1021/tx800098h
Autor:
Daniel J. Waldon, P E Sanders, Fengmei Hua, Joseph A. Ware, Charles G. Knutson, Mark P. Grillo
Publikováno v:
Drug Metabolism and Disposition. 31:1327-1336
Diclofenac, a nonsteroidal anti-inflammatory drug, is metabolized to a reactive acyl glucuronide that has been proposed to mediate toxic adverse drug reactions associated with its use. In the present study, we examined the ability of diclofenac acyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f148a877c684b14d8cc586190f1c8b56
https://doi.org/10.1124/dmd.31.11.1327
https://doi.org/10.1124/dmd.31.11.1327
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 37(1)
We previously reported that hepatobiliary transporter multidrug resistance-associated protein (MRP2/Mrp2) is considered to be the major cause of the interspecies differences detected by efflux of fluorescent substrates in isolated hepatocytes. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9cc8ef05e52d06485b86d14324bb10
https://pubmed.ncbi.nlm.nih.gov/18832477
https://pubmed.ncbi.nlm.nih.gov/18832477
Publikováno v:
Chemical research in toxicology. 16(11)
Diclofenac, a nonsteroidal anti-inflammatory drug, is metabolized to diclofenac-1-O-acyl glucuronide (D-1-O-G), a chemically reactive conjugate that has been implicated as playing a role in the idiosyncratic hepatoxicity associated with its use. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99200b9c9c135282ce317cbe6db4a1e
https://pubmed.ncbi.nlm.nih.gov/14615966
https://pubmed.ncbi.nlm.nih.gov/14615966
Autor:
Mark P. Grillo, Fengmei Hua
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 31(11)
Zomepirac (ZP), a nonsteroidal anti-inflammatory drug that was withdrawn from use, is metabolized to zomepirac-1-O-acyl-glucuronide (ZP-1-O-G), a chemically reactive conjugate that has been implicated in the toxicity of the drug. In the present studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0340dcecde51868eb1fafe1a27afb8
https://pubmed.ncbi.nlm.nih.gov/14570776
https://pubmed.ncbi.nlm.nih.gov/14570776