Cerebellar connectome alterations and associated genetic signatures in multiple sclerosis and neuromyelitis optica spectrum disorder

Autor: Yuping Yang, Junle Li, Ting Li, Zhen Li, Zhizheng Zhuo, Xuemei Han, Yunyun Duan, Guanmei Cao, Fenglian Zheng, Decai Tian, Xinli Wang, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Yuxin Li, Haiqing Li, Yongmei Li, Chun Zeng, Ningnannan Zhang, Jie Sun, Chunshui Yu, Fudong Shi, Umer Asgher, Nils Muhlert, Yaou Liu, Jinhui Wang

Publikováno v: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-14 (2023)

Abstract Background The cerebellum plays key roles in the pathology of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), but the way in which these conditions affect how the cerebellum communicates with the rest of the brain

Externí odkaz: https://doaj.org/article/6a84577478c54b169244634fc525be79

Subtyping relapsing–remitting multiple sclerosis using structural MRI

Autor: Jie Sun, Jinhui Wang, Chun Zeng, Frederik Barkhof, Fuqing Zhou, Yongmei Li, Xinli Wang, Yaou Liu, Guanmei Cao, Jinli Ding, Fu-Dong Shi, Xuemei Han, Sven Haller, Zhizheng Zhuo, Chunshui Yu, Yuxin Li, De-Cai Tian, Ningnannan Zhang, Kuncheng Li, Xinghu Zhang, Fenglian Zheng, Muhua Huang, Yunyun Duan, Haiqing Li

Publikováno v: Journal of Neurology, 268(5), 1808-1817. D. Steinkopff-Verlag
Zhuo, Z, Li, Y, Duan, Y, Cao, G, Zheng, F, Ding, J, Tian, D, Wang, X, Wang, J, Zhang, X, Li, K, Zhou, F, Huang, M, Li, Y, Li, H, Zeng, C, Zhang, N, Sun, J, Yu, C, Han, X, Haller, S, Barkhof, F, Shi, F & Liu, Y 2021, ' Subtyping relapsing–remitting multiple sclerosis using structural MRI ', Journal of Neurology, vol. 268, no. 5, pp. 1808-1817 . https://doi.org/10.1007/s00415-020-10376-7

Background and purpose: Subtyping relapsing–remitting multiple sclerosis (RRMS) patients may help predict disease progression and triage patients for treatment. We aimed to subtype RRMS patients by structural MRI and investigate their clinical sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610bb8cbd0e3fde4d124f647b00b805d
https://doi.org/10.1007/s00415-020-10376-7

Structural and functional hippocampal alterations in Multiple sclerosis and neuromyelitis optica spectrum disorder

Autor: Muhua Huang, Yongmei Li, Guanmei Cao, Chun Zeng, Fenglian Zheng, Yuxin Li, Yunyun Duan, Frederik Barkhof, Fuqing Zhou, Jie Sun, Ningnannan Zhang, Haiqing Li, Xinghu Zhang, Kuncheng Li, Xuemei Han, Zhizheng Zhuo, De-Cai Tian, Yaou Liu, Chunshui Yu, Sven Hallar

Publikováno v: Multiple Sclerosis Journal, 28(5), 707-717. SAGE Publications Ltd
Zheng, F, Li, Y, Zhuo, Z, Duan, Y, Cao, G, Tian, D, Zhang, X, Li, K, Zhou, F, Huang, M, Li, H, Li, Y, Zeng, C, Zhang, N, Sun, J, Yu, C, Han, X, Hallar, S, Barkhof, F & Liu, Y 2022, ' Structural and functional hippocampal alterations in Multiple sclerosis and neuromyelitis optica spectrum disorder ', Multiple Sclerosis Journal, vol. 28, no. 5, pp. 707-717 . https://doi.org/10.1177/13524585211032800

Background: Hippocampal involvement may differ between multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Objective: To investigate the morphometric, diffusion and functional alterations in hippocampus in MS and NMOSD and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc86af51d6941932a87f18dd51e4377
https://pubmed.ncbi.nlm.nih.gov/34379008

Volumetric reduction of cerebellar lobules associated with memory decline across the adult lifespan

Autor: Qingjian Meng, Tao Yin, Jianfeng Qiu, Wen Lu, Wang Huiqin, Dong Cui, Zhipeng Liu, Fenglian Zheng, Li Zhang

Publikováno v: Quantitative imaging in medicine and surgery. 10(1)

Background: The human cerebellum plays an essential role in motor control, is involved in cognitive function and helps to regulate emotional responses. However, little is known about the relationship between cerebellar lobules and age-related memory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76fd58ecc97f1921509f01ed8503d64
https://pubmed.ncbi.nlm.nih.gov/31956538

Age-related changes in fiber tracts in healthy adult brains: A generalized q-sampling and connectometry study

Autor: Lu Weizhao, Dong Cui, Xiaodong Gao, Zilong Yuan, Fenglian Zheng, Jindong Xie, Jianfeng Qiu, Xiaojing Liu, Li Zhang, Chen Zhang

Publikováno v: Journal of Magnetic Resonance Imaging. 48:369-381

BACKGROUND Generalized q-sampling (GQI) and connectometry analysis provide new indices, i.e., quantitative anisotropy (QA) and spin distribution function (SDF) in comparison with diffusion tensor imaging (DTI). They may provide more age-related chang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c234e1e9e7647f4258ae484ce056955
https://doi.org/10.1002/jmri.25949