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Akademický článek

PD-L1 monoclonal antibody-decorated nanoliposomes loaded with Paclitaxel and P-gp transport inhibitor for the synergistic chemotherapy against multidrug resistant gastric cancers

Autor: Jinling Yu, Fengli Hu, Qiankun Zhu, Xiaodong Li, Haiyang Ren, Shengjie Fan, Bo Qian, Bo Zhai, Dongdong Yang

Publikováno v: Nanoscale Research Letters, Vol 15, Iss 1, Pp 1-13 (2020)

Abstract Multidrug resistance (MDR) based on ATP-dependent efflux transporters (p-glycoprotein (p-gp)) remains a major obstacle in successful chemotherapy treatment. Herein, we have investigated the potential of PD-L1 mAb-conjugated nanoliposome to s

Externí odkaz: https://doaj.org/article/9859b68e0906432eb107e918092daea8

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Akademický článek

Fruiting Body Formation in Volvariella volvacea Can Occur Independently of Its MAT-A-Controlled Bipolar Mating System, Enabling Homothallic and Heterothallic Life Cycles

Autor: Bingzhi Chen, Arend F. van Peer, Junjie Yan, Xiao Li, Bin Xie, Juan Miao, Qianhui Huang, Lei Zhang, Wei Wang, Junsheng Fu, Xiang Zhang, Xiaoyin Zhang, Fengli Hu, Qingfang Kong, Xianyun Sun, Feng Zou, Hanxing Zhang, Shaojie Li, Baogui Xie

Publikováno v: G3: Genes, Genomes, Genetics, Vol 6, Iss 7, Pp 2135-2146 (2016)

Volvariella volvacea is an important crop in Southeast Asia, but erratic fruiting presents a serious challenge for its production and breeding. Efforts to explain inconsistent fruiting have been complicated by the multinucleate nature, typical lack o

Externí odkaz: https://doaj.org/article/9cf8e7d5634540dc8ad884d5ef9e58a5

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Akademický článek

Activation of phosphatidylinositol 3-kinase/AKT/snail signaling pathway contributes to epithelial-mesenchymal transition-induced multi-drug resistance to sorafenib in hepatocellular carcinoma cells.

Autor: Jiejie Dong, Bo Zhai, Weihua Sun, Fengli Hu, Hao Cheng, Jun Xu

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0185088 (2017)

Sorafenib, an orally available kinase inhibitor, is the standard first-line systemic drug for advanced hepatocellular carcinoma (HCC), and it exerts potent inhibitory activity against epithelial-mesenchymal transition (EMT) and multidrug resistance (

Externí odkaz: https://doaj.org/article/0afe5da2f81d42fc8812d5b824cb0534

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Akademický článek

Bufalin Reverses Resistance to Sorafenib by Inhibiting Akt Activation in Hepatocellular Carcinoma: The Role of Endoplasmic Reticulum Stress.

Autor: Bo Zhai, Fengli Hu, Haijiang Yan, Dali Zhao, Xin Jin, Taishi Fang, Shangha Pan, Xueying Sun, Lishan Xu

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0138485 (2015)

Sorafenib is the standard first-line therapeutic treatment for patients with advanced hepatocellular carcinoma (HCC), but its use is hampered by the development of drug resistance. The activation of Akt by sorafenib is thought to be responsible for t

Externí odkaz: https://doaj.org/article/7a4b86dc2356425fbc274d2188c8b556

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Akademický článek

High YKL-40 serum concentration is correlated with prognosis of Chinese patients with breast cancer.

Autor: Dong Wang, Bo Zhai, Fengli Hu, Chang Liu, Jinpeng Zhao, Jun Xu

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e51127 (2012)

This study aimed to investigate the association between serum YKL-40 and prognosis of breast cancer in a Chinese population. Expression of YKL-40 of 120 Chinese patients with breast cancer and 30 controls (benign breast lesions) was measured in tumor

Externí odkaz: https://doaj.org/article/92476dcb464d426b8c0d7cc34def6d9b

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