Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Fengjing Gu"'
Autor:
Kai Sun, Fan Lu, Liangcai Hou, Xiong Zhang, Chunran Pan, Haigang Liu, Zehang Zheng, Zhou Guo, Zhaoxuan Ruan, Yanjun Hou, Jinming Zhang, Fengjing Guo, Wentao Zhu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Z-DNA binding protein 1 (ZBP1) is a nucleic acid sensor that is involved in multiple inflammatory diseases, but whether and how it contributes to osteoarthritis (OA) are unclear. Methods Cartilage tissues were harvested from patie
Externí odkaz:
https://doaj.org/article/0af38da6199346bfb3e04df823d61627
Autor:
Rui Lu, Yunkun Qu, Zhenggang Wang, Zhiyi He, Shimeng Xu, Peng Cheng, Zhengtao Lv, Hongbo You, Fengjing Guo, Anmin Chen, Jiaming Zhang, Shuang Liang
Publikováno v:
Journal of Orthopaedic Translation, Vol 47, Iss , Pp 207-222 (2024)
Objectives: TANK-binding kinase 1 (TBK1) is pivotal in autoimmune and inflammatory diseases, yet its role in osteoarthritis (OA) remains elusive. This study sought to elucidate the effect of the TBK1 inhibitor BX795 on OA and to delineate the underly
Externí odkaz:
https://doaj.org/article/fede2b11d8404b65a820a8cbf5153851
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110741- (2024)
Summary: Osteoarthritis (OA) is a progressive degenerative joint disease, and the underlying molecular mechanisms of OA remain poorly understood. This study aimed to elucidate the relationship between mitochondrial autophagy and OA by identifying key
Externí odkaz:
https://doaj.org/article/5fcc3392826a4780951e76e6e811d2e4
Autor:
Jingting Xu, Zhaoxuan Ruan, Zhou Guo, Liangcai Hou, Genchun Wang, Zehang Zheng, Xiong Zhang, Haigang Liu, Kai Sun, Fengjing Guo
Publikováno v:
Bone & Joint Research, Vol 13, Iss 3, Pp 110-123 (2024)
Aims: Osteoarthritis (OA) is the most common chronic pathema of human joints. The pathogenesis is complex, involving physiological and mechanical factors. In previous studies, we found that ferroptosis is intimately related to OA, while the role of S
Externí odkaz:
https://doaj.org/article/bd074a90b237484faa68f1ebdcacbd21
Autor:
Chunran Pan, Fan Lu, Xiaoxia Hao, Xiaofeng Deng, Jiawei Liu, Kai Sun, Wenjie Hou, Xingru Shang, Ruimin Chi, Fengjing Guo, Tao Xu
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Osteoarthritis (OA) is a degenerative disease characterized by chronic inflammation of the joint. As the disease progresses, patients will gradually develop symptoms such as pain, physical limitations and even disability. The risk
Externí odkaz:
https://doaj.org/article/6a29278c40f94f7b92a70022f1aa18cf
Autor:
Yonghui Dong, Hui Liu, Xuejun Zhang, Fei Xu, Liang Qin, Peng Cheng, Hui Huang, Fengjing Guo, Qing Yang, Anmin Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7757 (2024)
The journal retracts the article “Inhibition of SDF-1α/CXCR4 Signalling in Subchondral Bone Attenuates Post-Traumatic Osteoarthritis” [...]
Externí odkaz:
https://doaj.org/article/bf1a2b50f5a14b64b41888df81c6f158
Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis
Autor:
Xiong Zhang, Liangcai Hou, Zhou Guo, Genchun Wang, Jingting Xu, Zehang Zheng, Kai Sun, Fengjing Guo
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Osteoarthritis (OA) is a multifactorial and increasingly prevalent degenerative disease that affects the whole joint. The pathogenesis of OA is poorly understood and there is a lack of therapeutic interventions to reverse the pathological pr
Externí odkaz:
https://doaj.org/article/87579b2e59174b4cb681a26955672487
Autor:
Liangcai Hou, Genchun Wang, Xiong Zhang, Fan Lu, Jingting Xu, Zhou Guo, Jiamin Lin, Zehang Zheng, Haigang Liu, Yanjun Hou, Kai Sun, Fengjing Guo
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108888- (2024)
Externí odkaz:
https://doaj.org/article/5ae49d18d94e4cae84802ac29cf6391d
Autor:
Kai Sun, Zhou Guo, Jinming Zhang, Liangcai Hou, Shuang Liang, Fan Lu, Genchun Wang, Jingting Xu, Xiong Zhang, Fengjing Guo, Wentao Zhu
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Osteoarthritis (OA) is an age-related disease characterized by cartilage degeneration. TNFR1-associated death domain protein (TRADD) is a key upstream molecule of TNF-α signals but its role in OA pathogenesis is unknown. This study aimed to
Externí odkaz:
https://doaj.org/article/c0ab250f28e945459b3d31f3d1e6d231
Autor:
Rui Lu, Haoran Xu, Xiaofeng Deng, Yingguang Wang, Zhiyi He, Shimeng Xu, Shuang Liang, Xiaojian Huang, Hongbo You, Fengjing Guo, Peng Cheng, An-min Chen
Publikováno v:
Journal of Orthopaedic Translation, Vol 39, Iss , Pp 74-87 (2023)
Background: The incidence of intervertebral disc degeneration (IVDD) is a common degenerative disease with inflammation, decreased autophagy, and progression of fibrosis as its possible pathogenesis. Physalin A (PA) is a widely studied anti-inflammat
Externí odkaz:
https://doaj.org/article/a03e4746eef24df594908cc1f8ce1341