Zobrazeno 1 - 10
of 81
pro vyhledávání: '"FengXia Xiao"'
Autor:
Bojin Zhao, Jiaheng Li, Siddharth Sinha, Zixin Qin, Si Hoi Kou, Fengxia Xiao, Huijun Lei, Tianhui Chen, Wenming Cao, Xiaofan Ding, San Ming Wang
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Genome stability is maintained by the DNA damage repair (DDR) system composed of multiple DNA repair pathways of hundreds of genes. Germline pathogenic variation (PV) in DDR genes damages function of the affected DDR genes, leadin
Externí odkaz:
https://doaj.org/article/9dbb202443294deeae552bed05a49163
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-10 (2024)
Abstract Background Mismatch repair (MMR) system is evolutionarily conserved for genome stability maintenance. Germline pathogenic variants (PVs) in MMR genes that lead to MMR functional deficiency are associated with high cancer risk. Knowing the ev
Externí odkaz:
https://doaj.org/article/56558a63c9c34cb1b10bcf982207b687
Autor:
Baoyu Mai, Ling Han, Jiarui Zhong, Jingqi Shu, Zelin Cao, Jiaqi Fang, Xiaoying Zhang, Zelin Gao, Fengxia Xiao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Alcoholic liver disease (ALD) is a common chronic liver disorder worldwide, which is detrimental to human health. A preliminary study showed that the total flavonoids within Citrus grandis “Tomentosa” exerted a remarkable effect on th
Externí odkaz:
https://doaj.org/article/b3044438d0dd4c1a81e0edcdc35ee870
Publikováno v:
ACS Omega, Vol 5, Iss 22, Pp 12777-12788 (2020)
Externí odkaz:
https://doaj.org/article/0ddd89c97a1c4116a9fca63869ce2e35
Autor:
Fengxia Xiao, Jiaheng Li, Philip Naderev Panuringan Lagniton, Si Hoi Kou, Huijun Lei, Benjamin Tam, San Ming Wang
Publikováno v:
Biomolecules, Vol 13, Iss 3, p 429 (2023)
MUTYH plays an essential role in preventing oxidation-caused DNA damage. Pathogenic germline variations in MUTYH damage its function, causing intestinal polyposis and colorectal cancer. Determination of the evolutionary origin of the variation is ess
Externí odkaz:
https://doaj.org/article/262f74baf7e34e8ea72fff1050f9009f
Autor:
Marcel Ruzicka, Fengxia Xiao, Hussein Abujrad, Yasamin Al-Rewashdy, Vera A. Tang, Marc-André Langlois, Alexander Sorisky, Teik Chye Ooi, Dylan Burger
Publikováno v:
BMC Nephrology, Vol 20, Iss 1, Pp 1-8 (2019)
Abstract Background Although hemodialysis is a highly effective treatment for diffusive clearance of low molecular weight uremic toxins, its effect on circulating extracellular vesicles and submicron particles is less clear. The purpose of this study
Externí odkaz:
https://doaj.org/article/2a4c3d6f5dc2441798ee1cc3ada5dcb2
Autor:
Mercedes N. Munkonda, Shareef Akbari, Chloe Landry, Suzy Sun, Fengxia Xiao, Maddison Turner, Chet E. Holterman, Rania Nasrallah, Richard L. Hébert, Christopher R. J. Kennedy, Dylan Burger
Publikováno v:
Journal of Extracellular Vesicles, Vol 7, Iss 1 (2018)
Tubulointerstitial fibrosis is a hallmark of advanced diabetic kidney disease that is linked to a decline in renal function, however the pathogenic mechanisms are poorly understood. Microparticles (MPs) are 100–1000 nm vesicles shed from injured ce
Externí odkaz:
https://doaj.org/article/aa97d5bb720e4bfb9b20b1ec33f5bd9c
Autor:
Fengxia Xiao, Joseph Zimpelmann, Samih Agaybi, Susan B Gurley, Lawrence Puente, Kevin D Burns
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85958 (2014)
Angiotensin-converting enzyme 2 (ACE2) is highly expressed in the kidney proximal tubule, where it cleaves angiotensin (Ang) II to Ang-(1-7). Urinary ACE2 levels increase in diabetes, suggesting that ACE2 may be shed from tubular cells. The aim of th
Externí odkaz:
https://doaj.org/article/d6ec551fbbc140c0a4727aa28d5fc554
Autor:
Fengxia Xiao, Yeong C Kim, Hongxiu Wen, Jiangtao Luo, Peixian Chen, Kenneth Cowan, San Ming Wang
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78685 (2013)
Genetic studies often use genomic DNA from whole blood cells, of which the majority are the polymorphonuclear myeloid cells. Those cells undergo dramatic change of nuclear morphology following cellular differentiation. It remains elusive if the nucle
Externí odkaz:
https://doaj.org/article/88dc56a939bf40649f311537441ec36d
Autor:
Fengxia Xiao, Swapnil Hiremath, Greg Knoll, Joseph Zimpelmann, Kajenny Srivaratharajah, Deepak Jadhav, Dean Fergusson, Chris R J Kennedy, Kevin D Burns
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37649 (2012)
Angiotensin-converting enzyme 2 (ACE2) is expressed in the kidney and may be a renoprotective enzyme, since it converts angiotensin (Ang) II to Ang-(1-7). ACE2 has been detected in urine from patients with chronic kidney disease. We measured urinary
Externí odkaz:
https://doaj.org/article/477579ad14544d03a13fcae62e1094a6