Výsledky vyhledávání - "Feng-jue Shu"

Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons

Autor: David Weinshenker, Suneela Ramineni, Feng-jue Shu, Christopher D. Scharer, Matthew C. Tillman, John R. Hepler, Jason P. Schroeder, Kyle J. Gerber, Katherine E. Squires, Meilan Zhao, Ramendra N. Saha, Eric A. Ortlund, Serena M. Dudek, Carolina Montañez-Miranda, Daniel Lustberg

Publikováno v: The Journal of Biological Chemistry

The human genome contains vast genetic diversity as naturally occurring coding variants, yet the impact of these variants on protein function and physiology is poorly understood. RGS14 is a multifunctional signaling protein that suppresses synaptic p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba6b9a078a564b3d20bb998c3c1d322
https://escholarship.org/uc/item/7xb4h01s

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Cell-type specific role of the RNA-binding protein, NONO, in the DNA double-strand break response in the mouse testes

Autor: Shourong Zhao, Lahcen Jaafar, William S. Dynan, Shuyi Li, Zhentian Li, Feng-jue Shu

Publikováno v: DNA repair. 51

The tandem RNA recognition motif protein, NONO, was previously identified as a candidate DNA double-strand break (DSB) repair factor in a biochemical screen for proteins with end-joining stimulatory activity. Subsequent work showed that NONO and its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9917854f8d236f3ac36db4aacc7b2d06
https://pubmed.ncbi.nlm.nih.gov/28209515

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The mRNA-Binding Protein Zfp36 Is Upregulated by β-Adrenergic Stimulation and Represses IL-6 Production in 3T3-L1 Adipocytes

Autor: Caleb B. Kallen, Huanchun Zhang, Pavna Kartha Brahma, Betsy S. Murray, Neil Sidell, Emre Seli, Feng-jue Shu

Publikováno v: Obesity. 20:40-47

Obesity produces a chronic inflammatory state that contributes to the development of diabetes and atherosclerosis. In obese humans, fat depot adipocytes and macrophages produce inflammatory cytokines and other factors which exert unfavorable local an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31e72cb35c82a0c65c8840079ef5a36
https://doi.org/10.1038/oby.2011.259

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Intercalation of XR5944 with the estrogen response element is modulated by the tri-nucleotide spacer sequence between half-sites

Autor: Zhenjiang Zhang, Feng jue Shu, Caleb B. Kallen, Danzhou Yang, Neil Sidell, Raveendra I. Mathad

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 124:121-127

DNA-intercalating molecules can impair DNA replication, DNA repair, and gene transcription. We previously demonstrated that XR5944, a DNA bis-intercalator, specifically blocks binding of estrogen receptor-α (ERα) to the consensus estrogen response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb2f54d751bb64ace837c4da514858b
https://doi.org/10.1016/j.jsbmb.2011.02.003

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Activation of the Regulator of G Protein Signaling 14−Gαi1-GDP Signaling Complex Is Regulated by Resistance to Inhibitors of Cholinesterase-8A

Autor: Feng Jue Shu, Gregory G. Tall, Suneela Ramineni, Christopher P. Vellano, Cindee K. Yates, John R. Hepler

Publikováno v: Biochemistry. 50:752-762

Conventional models of G protein signaling (1, 2) indicate that activated G protein-coupled receptors (GPCRs) serve as guanine nucleotide exchange factors (GEFs) towards coupled heterotrimeric (Gαβγ) G proteins. GPCR activation facilitates GDP rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abc5c0ab1361a65d19c9af76017157cb
https://doi.org/10.1021/bi101910n

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The tri-nucleotide spacer sequence between estrogen response element half-sites is conserved and modulates ERα-mediated transcriptional responses

Autor: Caleb B. Kallen, Neil Sidell, Danzhou Yang, Feng jue Shu

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 120:172-179

The estrogen response element (ERE) consensus sequence is AGGTCAnnnTGACCT, where nnn is known as the tri-nucleotide spacer sequence. Studying 1017 high-confidence ERα-bound loci, we found that genomic EREs are enriched for spacers composed of C(A/T)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377e2d3f47ffc84a32264726be75f4a0
https://doi.org/10.1016/j.jsbmb.2010.04.009

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RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways

Autor: John R. Hepler, Suneela Ramineni, Feng-jue Shu

Publikováno v: Cellular Signalling. 22:366-376

MAPkinase signalling is essential for cell growth, differentiation and cell physiology. G proteins and tyrosine kinase receptors each modulate MAPkinase signalling through distinct pathways. We report here that RGS14 is an integrator of G protein and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd681e8458046509cb69fab5df251135
https://doi.org/10.1016/j.cellsig.2009.10.005

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Location analysis for the estrogen receptor-alpha reveals binding to diverse ERE sequences and widespread binding within repetitive DNA elements

Autor: Roland G. Kallen, Cheng Wang, Tianwei Yu, Caleb B. Kallen, Ryan M. Session, Feng-jue Shu, Christopher E. Mason, Edwin Cheung, Mei Hui Liu, Neil Sidell

Publikováno v: Nucleic Acids Research

Location analysis for estrogen receptor-alpha (ERalpha)-bound cis-regulatory elements was determined in MCF7 cells using chromatin immunoprecipitation (ChIP)-on-chip. Here, we present the estrogen response element (ERE) sequences that were identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6142d015c8f5d6d9b19043fee0fa61f6
https://pubmed.ncbi.nlm.nih.gov/20047966

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