Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Feng-Xu Wu"'
Autor:
Li-Na Ke, Ling-Qi Kong, Xiu-Lian Zhu, Feng-Xu Wu, Qin-Hua Chen, Bin Li, Yun Dong, Hong-Mei Wang, Xiao-Hua Zeng
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
We have synthesized Rhopaladins’ analog (2E,4E)-4-chlorobenzylidene-2-(4-chlorostyryl)-N-cyclohexyl-1-(4-fluorophenyl)-5-oxopyrrolidine-2-carboxamide (RPDPRH) via a highly facile, inexpensive and green approach and verified the structural superiori
Externí odkaz:
https://doaj.org/article/4092eb5537d84574b2ac145bcd7d0de3
Publikováno v:
Journal of Cheminformatics, Vol 11, Iss 1, Pp 1-11 (2019)
Abstract Drug repurposing offers a promising alternative to dramatically shorten the process of traditional de novo development of a drug. These efforts leverage the fact that a single molecule can act on multiple targets and could be beneficial to i
Externí odkaz:
https://doaj.org/article/83ff7bd828a74282bed7b875fc9eff19
Autor:
Hong-Yan Lin, Xi Chen, Jia-Nan Chen, Da-Wei Wang, Feng-Xu Wu, Song-Yun Lin, Chang-Guo Zhan, Jia-Wei Wu, Wen-Chao Yang, Guang-Fu Yang
Publikováno v:
Research, Vol 2019 (2019)
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a promising target for drug and pesticide discovery. The unknown binding mode of substrate is still a big challenge for the understanding of enzymatic reaction mechanism and novel HPPD inhibitor design. H
Externí odkaz:
https://doaj.org/article/f563e3f5b05a4bb29f3b5592cbc60599
Autor:
Zhi-Cheng Yu, Hong-Chuang Xu, Guang-Fu Yang, Feng-Xu Wu, Lin-Sheng Zhuo, Chao Pang, Wei Huang, Yan-Guang Tian, Yi Gong, Ge-Fei Hao, Ming-Shu Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:15503-15514
Tropomyosin receptor kinase (TRK) inhibition is an effective therapeutic approach for treatment of a variety of cancers. Despite the use of first-generation TRK inhibitor (TRKI) larotrectinib (1) resulting in significant therapeutic response in patie
Autor:
Liang-Kun Yu, Guang-Fu Yang, Lei Wu, Feng-Xu Wu, Qiong Chen, Ge-Fei Hao, Wen-Chao Yang, Bo He, Hong-Yan Lin
Publikováno v:
Journal of Agricultural and Food Chemistry. 68:5059-5067
4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) has been identified as one of the most significant targets in herbicide discovery for resistant weed control. In a continuing effort to discover potent novel HPPD inhibitors, we adopted a ring
Publikováno v:
European Journal of Medicinal Chemistry. 241:114654
Several secondary tropomyosin receptor kinase (TRK) mutations located in the solvent front, xDFG, and gatekeeper regions, are a common cause of clinical resistance. Mutations in the xDFG motif in particular limit sensitivity to second-generation TRK
Autor:
Ming-Shu Wang, Feng-Xu Wu, Zhi-Cheng Yu, Chao Pang, Huang Wei, Guang-Fu Yang, Yan-Guang Tian, Zhuo Linsheng, Yi Gong, Geifei Hao, Hong-Chuang Xu
Aberrant signaling from tropomyosin receptor kinases (TRKs) has been identified as the oncogenic driver in a large variety of cancers, suggesting that inhibition of TRK may be an attractive strategy of attack for anticancer therapeutics. Despite the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ed2b8d1668d87f57b497f295acd1540
https://doi.org/10.21203/rs.3.rs-597552/v1
https://doi.org/10.21203/rs.3.rs-597552/v1
Autor:
Ying Tan, Boren Xiao, Yuyang Jiang, Yueying Zhang, Feng-Xu Wu, Xiaoting Huang, Jiewen Zhang, Haiyang Liu
Publikováno v:
New Journal of Chemistry. 43:6848-6855
A dicyanoisophorone-based near-infrared fluorescent probe (NIR-NP) was successfully designed for hydrogen sulfide (H2S) detection. 7-Nitro-1,2,3-benzoxadiazole (NBD) amine, an electron-withdrawing group, was applied to quench the fluorescence of dicy
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100312-(2021)
Summary Hit-to-lead (H2L) optimization is crucial for drug design, which has become an increasing concern in medicinal chemistry. A virtual screening strategy of auto in silico ligand directing evolution (AILDE) has been developed to yield promising
Publikováno v:
Briefings in Bioinformatics
Protein–nucleic acid interactions play essential roles in many biological processes, such as transcription, replication and translation. In protein–nucleic acid interfaces, hotspot residues contribute the majority of binding affinity toward molec