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Quantitative Proteomics Reveals That the Inhibition of Na(+)/K(+)-ATPase Activity Affects S-Phase Progression Leading to a Chromosome Segregation Disorder by Attenuating the Aurora A Function in Hepatocellular Carcinoma Cells

Autor: Shi-Xiang Cheng, Fengmei Wang, Ruicheng Xu, Yueying Song, Chengyan Wang, Yanjun Gu, Feng-Xu Fan, Xiangyan Meng, Nana Shan, Ying-Fu Liu, Zhong-Wei Xu

Publikováno v: Journal of proteome research. 14(11)

Many studies have shown the Na(+)/K(+)-ATPase (NKA) might be a potential target for anticancer therapy. Cardiac glycosides (CGs), as a family of naturally compounds, inhibited the NKA activity. The present study investigates the antitumor effect of o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d0ab5fb442134dea5585e94048a675
https://pubmed.ncbi.nlm.nih.gov/26491887

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SILAC-based proteomic analysis reveals that salidroside antagonizes cobalt chloride-induced hypoxic effects by restoring the tricarboxylic acid cycle in cardiomyocytes

Autor: Yu-Ming Li, Xi Chen, Shi-Yun Mao, Xiangyan Meng, Nana Shan, Feng-Xu Fan, Xin Zhou, Wen-Cheng Zhang, Yue Wang, Zhongwei Xu, Ruicheng Xu, Xiaohan Jin

Publikováno v: Journal of proteomics. 130

Hypoxic status alters the energy metabolism and induces cell injury in cardiomyocytes, and it further triggers the occurrence and development of cardiovascular diseases. Our previous studies have shown that salidroside (SAL) exhibits anti-hypoxic act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6bdd3a7353d2805c87091e4d76a0de
https://pubmed.ncbi.nlm.nih.gov/26435418

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