Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Feng V. Yang"'
Autor:
Martin Patrick Allen, Lorraine A. Lebel, Feng V. Yang, Christopher J. Schmidt, Spiros Liras, Kimberly G. Estep, Thomas Allen Chappie, Meihua Tu, Robert D. Williams, Carol B. Fox, Jayvardhan Pandit, John M. Humphrey, Frank S. Menniti, Eric S. Marr
Publikováno v:
Journal of Medicinal Chemistry. 50:182-185
A papaverine based pharmacophore model for PDE10A inhibition was generated via SBDD and used to design a library of 4-amino-6,7-dimethoxyquinazolines. From this library emerged an aryl ether pyrrolidyl 6,7-dimethoxyquinazoline series that became the
Autor:
Lei Ma, James C. Barrow, Matthew A. Seager, George D. Hartman, Kenneth A. Koeplinger, Feng V. Yang, M. Brad Nolt, William J. Ray, Zhijian Zhao, Craig W. Lindsley, William D. Shipe, David D. Wisnoski, Jaime L. Bunda, Marion Wittmann
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(2)
An iterative analog library synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M(1) positive allosteric modulators, and strategies for improving potency and plasma free fraction were identified.
Autor:
Thomas A. Chappie, John M. Humphrey, Martin P. Allen, Kimberly G. Estep, Carol B. Fox, Lorraine A. Lebel, Spiros Liras, Eric S. Marr, Frank S. Menniti, Jayvardhan Pandit, Christopher J. Schmidt, Meihua Tu, Robert D. Williams, Feng V. Yang
Publikováno v:
Journal of Medicinal Chemistry; Jan2007, Vol. 50 Issue 2, p182-185, 4p