Inferring upstream regulatory genes of FOXP3 in human regulatory T cells from time-series transcriptomic data

Autor: Stefano Magni, Rucha Sawlekar, Christophe M. Capelle, Vera Tslaf, Alexandre Baron, Ni Zeng, Laurent Mombaerts, Zuogong Yue, Ye Yuan, Feng Q. Hefeng, Jorge Gonçalves

Publikováno v: npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-13 (2024)

Abstract The discovery of upstream regulatory genes of a gene of interest still remains challenging. Here we applied a scalable computational method to unbiasedly predict candidate regulatory genes of critical transcription factors by searching the w

Externí odkaz: https://doaj.org/article/ed7e7d476a09458eb90fc0009e2c3a12

Altered infective competence of the human gut microbiome in COVID-19

Autor: Laura de Nies, Valentina Galata, Camille Martin-Gallausiaux, Milena Despotovic, Susheel Bhanu Busi, Chantal J. Snoeck, Lea Delacour, Deepthi Poornima Budagavi, Cédric Christian Laczny, Janine Habier, Paula-Cristina Lupu, Rashi Halder, Joëlle V. Fritz, Taina Marques, Estelle Sandt, Marc Paul O’Sullivan, Soumyabrata Ghosh, Venkata Satagopam, CON-VINCE Consortium, Rejko Krüger, Guy Fagherazzi, Markus Ollert, Feng Q. Hefeng, Patrick May, Paul Wilmes

Publikováno v: Microbiome, Vol 11, Iss 1, Pp 1-16 (2023)

Abstract Background Infections with SARS-CoV-2 have a pronounced impact on the gastrointestinal tract and its resident microbiome. Clear differences between severe cases of infection and healthy individuals have been reported, including the loss of c

Externí odkaz: https://doaj.org/article/847f0016b0ce43638b01f6e07ee58c01

DJ-1 depletion prevents immunoaging in T-cell compartments

Autor: Ni Zeng, Christophe M Capelle, Alexandre Baron, Takumi Kobayashi, Severine Cire, Vera Tslaf, Cathy Leonard, Djalil Coowar, Haruhiko Koseki, Astrid M Westendorf, Jan Buer, Dirk Brenner, Rejko Krüger, Rudi Balling, Markus Ollert, Feng Q Hefeng

Publikováno v: Zeng, N, Capelle, C M, Baron, A, Kobayashi, T, Cire, S, Tslaf, V, Leonard, C, Coowar, D, Koseki, H, Westendorf, A M, Buer, J, Brenner, D, Krüger, R, Balling, R, Ollert, M & Hefeng, F Q 2022, ' DJ-1 depletion prevents immunoaging in T-cell compartments ', EMBO Reports, vol. 23, no. 3, e53302 . https://doi.org/10.15252/embr.202153302

Decline in immune function during aging increases susceptibility to different aging-related diseases. However, the underlying molecular mechanisms, especially the genetic factors contributing to imbalance of naïve/memory T-cell subpopulations, still

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e5fe06fa50ef80c1ef1beaecaf5940
https://findresearcher.sdu.dk:8443/ws/files/197720118/EMBO_Reports_2022_Zeng_DJ_1_depletion_prevents_immunoaging_in_T_cell_compartments.pdf

Stress hormone signalling inhibits Th1 polarization in a CD4 T-cell-intrinsic manner via mTORC1 and the circadian gene PER1

Autor: Christophe M. Capelle, Anna Chen, Ni Zeng, Alexandre Baron, Kamil Grzyb, Thais Arns, Alexander Skupin, Markus Ollert, Feng Q. Hefeng

Publikováno v: Capelle, C M, Chen, A, Zeng, N, Baron, A, Grzyb, K, Arns, T, Skupin, A, Ollert, M & Hefeng, F Q 2022, ' Stress hormone signalling inhibits Th1 polarization in a CD4 T-cell-intrinsic manner via mTORC1 and the circadian gene PER1 ', Immunology, vol. 165, no. 4, pp. 428-444 . https://doi.org/10.1111/imm.13448

Stress hormones are believed to skew the CD4 T-cell differentiation towards a Th2 response via a T-cell-extrinsic mechanism. Using isolated primary human naïve and memory CD4 T cells, here we show that both adrenergic- and glucocorticoid-mediated st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb3fed57211c1b36adfa6ca2cf599d7
https://www.ncbi.nlm.nih.gov/pubmed/35143696

DJ-1 depletion slows down immunoaging in T-cell compartments

Autor: Djalil Coowar, Christophe Capelle, C. Leonard, Markus Ollert, Westendorf Am, Balling R, Jan Buer, Alexandre Baron, Ni Zeng, Rejko Krüger, Feng Q. Hefeng, Cire S, Dirk Brenner, Koseki H

Decline in immune function during aging increases susceptibility to different aging related diseases. However, the underlying molecular mechanisms, especially the genetic factors contributing to imbalance of naïve/memory T-cell subpopulations, still

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b38c55ed2e9178a5de788897764eb61
https://doi.org/10.1101/2021.05.21.445139