Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Feng J Gao"'
Autor:
Dylan C Sarver, Cheng Xu, Susana Rodriguez, Susan Aja, Andrew E Jaffe, Feng J Gao, Michael Delannoy, Muthu Periasamy, Yasuhiro Kazuki, Mitsuo Oshimura, Roger H Reeves, G William Wong
Publikováno v:
eLife, Vol 12 (2023)
The consequences of aneuploidy have traditionally been studied in cell and animal models in which the extrachromosomal DNA is from the same species. Here, we explore a fundamental question concerning the impact of aneuploidy on systemic metabolism us
Externí odkaz:
https://doaj.org/article/3aeea4fdb24949308434aa922bedcafd
Autor:
Yasuhiro Kazuki, Feng J Gao, Yicong Li, Anna J Moyer, Benjamin Devenney, Kei Hiramatsu, Sachiko Miyagawa-Tomita, Satoshi Abe, Kanako Kazuki, Naoyo Kajitani, Narumi Uno, Shoko Takehara, Masato Takiguchi, Miho Yamakawa, Atsushi Hasegawa, Ritsuko Shimizu, Satoko Matsukura, Naohiro Noda, Narumi Ogonuki, Kimiko Inoue, Shogo Matoba, Atsuo Ogura, Liliana D Florea, Alena Savonenko, Meifang Xiao, Dan Wu, Denise AS Batista, Junhua Yang, Zhaozhu Qiu, Nandini Singh, Joan T Richtsmeier, Takashi Takeuchi, Mitsuo Oshimura, Roger H Reeves
Publikováno v:
eLife, Vol 9 (2020)
Animal models of Down syndrome (DS), trisomic for human chromosome 21 (HSA21) genes or orthologs, provide insights into better understanding and treatment options. The only existing transchromosomic (Tc) mouse DS model, Tc1, carries a HSA21 with over
Externí odkaz:
https://doaj.org/article/902bee1fcc954ec09607d3e505b90a1b
Autor:
Dylan C. Sarver, Cheng Xu, Susana Rodriguez, Susan Aja, Andrew E. Jaffe, Feng J. Gao, Michael Delannoy, Muthu Periasamy, Yasuhiro Kazuki, Mitsuo Oshimura, Roger H. Reeves, G. William Wong
The consequences of aneuploidy have traditionally been studied in cell and animal models in which the extrachromosomal DNA is from the same species. Here, we explore a fundamental question concerning the impact of aneuploidy on systemic metabolism us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a7ef26f2ce24c33cd72459a67c65c14
https://doi.org/10.1101/2023.01.30.526183
https://doi.org/10.1101/2023.01.30.526183
Publikováno v:
Pharmaceutics; Volume 14; Issue 2; Pages: 373
The inherent instability of nucleic acids within serum and the tumor microenvironment necessitates a suitable vehicle for non-viral gene delivery to malignant lesions. A specificity-conferring mechanism is also often needed to mitigate off-target tox
Autor:
Bei Cheng, Moeka Koshima, Makoto Sanbo, Yasuhiro Kazuki, Hiroshi Kuniishi, Yuji Nakayama, Mitsuo Oshimura, Feng J. Gao, Satoko Matsukura, Yuich Iida, Naoyo Kajitani, Joan T. Richtsmeier, Kanako Kazuki, Roger H. Reeves, Sachiko Miyagawa-Tomita, Masumi Hirabayashi, Hiromasa Hara, Anna J. Moyer, Satoshi Ichisaka, Miho Yamakawa, Haruka Takayama, Yoshio Hata, Yicong Li, Naohiro Noda, Masaharu Hiratsuka, Shoko Takehara, Nandini Singh, Satoshi Abe
Progress in earlier detection and symptom management has increased life expectancy and quality of life in people with Down syndrome (DS). However, no drug has been approved to help individuals with DS live independently and fully. Although rat models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::945f357459691b5818f7e80c648e75b9
https://doi.org/10.1101/2021.10.03.462958
https://doi.org/10.1101/2021.10.03.462958
Autor:
Fabian-Xosé Fernandez, Alena Savonenko, Martin G. Pomper, Bei Cheng, Dan Wu, Benjamin Devenney, Feng J. Gao, Roger H. Reeves, Donna Klinedinst, Yicong Li
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-21 (2021)
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-21 (2021)
Down syndrome (DS) is the leading genetic cause of intellectual disability and causes early-onset dementia and cerebellar hypoplasia. The prevalence of attention deficit hyperactivity disorder is elevated in children with DS. The aneuploid DS mouse m
Publikováno v:
Brain Communications
The cerebellum is a complex system with distinct cortical laminar organization. Alterations in cerebellar microstructure are common and associated with many factors such as genetics, cancer and ageing. Diffusion MRI (dMRI) provides a non-invasive too
Autor:
Feng J. Gao, Donna Klinedinst, Fabian-Xosé Fernandez, Bei Cheng, Alena Savonenko, Benjamin Devenney, Yicong Li, Dan Wu, Martin G. Pomper, Roger H. Reeves
SummaryPeople with Down syndrome (DS) have intellectual disability, early-onset dementia, and cerebellar hypoplasia. Trisomic cerebellar granule cell precursors from Ts65Dn, a mouse model of DS, had a deficit in mitogenic response to Sonic hedgehog (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39cf12c80d9cfac54e9ae37b1c6ad51f
https://doi.org/10.1101/2021.01.18.427185
https://doi.org/10.1101/2021.01.18.427185
Autor:
Takashi Takeuchi, Masato Takiguchi, Atsushi Hasegawa, Denise A.S. Batista, Joan T. Richtsmeier, Satoshi Abe, Zhaozhu Qiu, Ritsuko Shimizu, Narumi Ogonuki, Shoko Takehara, Liliana Florea, Anna J. Moyer, Yasuhiro Kazuki, Miho Yamakawa, Atsuo Ogura, Narumi Uno, Benjamin Devenney, Feng J. Gao, Kanako Kazuki, Yicong Li, Kimiko Inoue, Roger H. Reeves, Meifang Xiao, Sachiko Miyagawa-Tomita, Satoko Matsukura, Nandini Singh, Naoyo Kajitani, Junhua Yang, Kei Hiramatsu, Shogo Matoba, Naohiro Noda, Alena Savonenko, Dan Wu, Mitsuo Oshimura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db2c2f0d1146323d0cc575cd2561e3c0
https://doi.org/10.7554/elife.56223.sa2
https://doi.org/10.7554/elife.56223.sa2
Autor:
Dan Wu, Atsushi Hasegawa, Naoyo Kajitani, Satoshi Abe, Ritsuko Shimizu, Alena Savonenko, Satoko Matsukura, Narumi Uno, Anna J. Moyer, Kimiko Inoue, Atsuo Ogura, Miho Yamakawa, Shoko Takehara, Roger H. Reeves, Kanako Kazuki, Narumi Ogonuki, Naohiro Noda, Junhua Yang, Sachiko Miyagawa-Tomita, Joan T. Richtsmeier, Zhaozhu Qiu, Yasuhiro Kazuki, Masato Takiguchi, Mitsuo Oshimura, Kei Hiramatsu, Benjamin Devenney, Meifang Xiao, Takashi Takeuchi, Feng J. Gao, Shogo Matoba, Nandini Singh, Liliana Florea, Denise A.S. Batista, Yicong Li
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Animal models of Down syndrome (DS), trisomic for human chromosome 21 (HSA21) genes or orthologs, provide insights into better understanding and treatment options. The only existing transchromosomic (Tc) mouse DS model, Tc1, carries a HSA21 with over