Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Feng‐Hou Gao"'
Autor:
Zhen Liu, Xiao-Yang Wang, Han-Wei Wang, Shan-Ling Liu, Chao Zhang, Feng Liu, Ying Guo, Feng-Hou Gao
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Background CDK4 is highly expressed and associated with poor prognosis and decreased survival in advanced neuroblastoma (NB). Targeting CDK4 degradation presents a potentially promising therapeutic strategy compared to conventional CDK4 inhibitors. H
Externí odkaz:
https://doaj.org/article/02fce2f3dc094d7e8fccb62f6aa4ddfb
Autor:
Hu Lei, Han-Zhang Xu, Hui-Zhuang Shan, Meng Liu, Ying Lu, Zhi-Xiao Fang, Jin Jin, Bo Jing, Xin-Hua Xiao, Shen-Meng Gao, Feng-Hou Gao, Li Xia, Li Yang, Li-Gen Liu, Wei-Wei Wang, Chuan-Xu Liu, Yin Tong, Yun-Zhao Wu, Jun-Ke Zheng, Guo-Qiang Chen, Li Zhou, Ying-Li Wu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Resistance to tyrosine kinase inhibitors (TKI) is a limitation to their use in treating chronic myelogenous leukemia (CML). Here, the authors show that targeting the ubiquitin peptidase USP47 overcomes TKI resistance and eliminates leukaemia stem/pro
Externí odkaz:
https://doaj.org/article/ef7347958ad8427eacd75d192110f022
Autor:
Han‐Qing Zhu, Chao Zhang, Zhu‐Ying Guo, Jun‐Mei Yang, Jia‐Hui Guo, Chen Chen, Qiang‐Hua Yao, Feng Liu, Quan‐Wu Zhang, Feng‐Hou Gao
Publikováno v:
Cancer Medicine, Vol 8, Iss 11, Pp 5313-5326 (2019)
Abstract Oridonin could induce NB (neuroblastoma) cells growth inhibition by inducing apoptosis and cell cycle arrest, and the molecular mechanisms behind the effects deserve to be further explored. Here, oridonin was confirmed to cause the reactivat
Externí odkaz:
https://doaj.org/article/e762cfa2d4ef48b1a586f2a843f051e4
Autor:
Shan-Shan Yin, Feng-Hou Gao
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Tumor immune escape is an important part of tumorigenesis and development. Tumor cells can develop a variety of immunosuppressive mechanisms to combat tumor immunity. Exploring tumor cells that escape immune surveillance through the molecular mechani
Externí odkaz:
https://doaj.org/article/bd4b4f69c59f499a8ed410876c3a395f
Autor:
Chen Chen, Feng-Hou Gao
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The progressive infiltration of immune cells is associated with the progression of melanoma. Specifically, Th17 cells in melanoma microenvironment have both antitumor and protumor effects. It is now necessary to understand the contradictory data asso
Externí odkaz:
https://doaj.org/article/764a723b773e408888576508abd7affe
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0159998 (2016)
Recent research found that Tiron was an effective antioxidant that could act as the intracellular reactive oxygen species (ROS) scavenger or alleviate the acute toxic metal overload in vivo. In this study, we investigated the inhibitory effect of Tir
Externí odkaz:
https://doaj.org/article/60c1706acef34bf7b334a6470c84523a
Autor:
Dong-Jun Qin, Cai-Xia Tang, Li Yang, Hu Lei, Wei Wei, Ying-Ying Wang, Chun-Min Ma, Feng-Hou Gao, Han-Zhang Xu, Ying-Li Wu
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132337 (2015)
Synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9(11)-dien-28-oate (CDDO-Me) has been shown as a promising agent against ovarian cancer. However, the underlying mechanism is not well understood. Here, we demonstrate that CDDO-Me directly i
Externí odkaz:
https://doaj.org/article/0cefc8407a8c4d208373376ab00fdb44
Autor:
Shan-Shan Yin, Chen Chen, Zhen Liu, Shan-Ling Liu, Jia-Hui Guo, Chao Zhang, Quan-Wu Zhang, Feng-Hou Gao
Publikováno v:
Cell Cycle. :1-14
Publikováno v:
Biochemical and Biophysical Research Communications. 627:5-11
CDK4 is highly expressed and correlated with poor prognosis and decreased survival in advanced NB. Seeking a regimen that selectively targets CDK4 degradation is a potentially promising therapeutic strategy relative to conventional CDK4 inhibitors.In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::331bf1c1abbb5aecedb203804d75f312
https://doi.org/10.21203/rs.3.rs-2909289/v1
https://doi.org/10.21203/rs.3.rs-2909289/v1