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The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1.

Autor: Wang M; Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, China., Gu Y; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing 400016, China., Li Q; Department of Pediatrics, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, China., Feng B; Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, China., Lv X; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing 400016, China., Zhang H; Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, China., Kong Q; Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, China., Dong Z; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China., Tian X; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing 400016, China., Zhang Y; Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, China.; Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.

Publikováno v: Genes & diseases [Genes Dis] 2023 Jun 24; Vol. 11 (3), pp. 100997. Date of Electronic Publication: 2023 Jun 24 (Print Publication: 2024).