Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Fena, Ochs"'
Autor:
Amaia Ercilla, Jan Benada, Sampath Amitash, Gijs Zonderland, Giorgio Baldi, Kumar Somyajit, Fena Ochs, Vincenzo Costanzo, Jiri Lukas, Luis Toledo
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2416-2429.e7 (2020)
Summary: It has been long assumed that normally leading strand synthesis must proceed coordinated with the lagging strand to prevent strand uncoupling and the pathological accumulation of single-stranded DNA (ssDNA) in the cell, a dogma recently chal
Externí odkaz:
https://doaj.org/article/73db0e73783b49159fbdafe2bd7e3417
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2476
Continuing progress in super-resolution microscopy enables the study of sub-chromosomal chromatin organization in single cells with unprecedented detail. Here we describe refined methods for pulse-chase replication labeling of individual chromosome t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ecd74bb32472e7113019a33f22f3269
https://pubmed.ncbi.nlm.nih.gov/35635700
https://pubmed.ncbi.nlm.nih.gov/35635700
Publikováno v:
Methods in Molecular Biology ISBN: 9781071622209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad9f3ded64bb6744b38e4d4ac4ab617f
https://doi.org/10.1007/978-1-0716-2221-6_9
https://doi.org/10.1007/978-1-0716-2221-6_9
Autor:
Leonardo Scapozza, Thanos D. Halazonetis, Jiri Lukas, Noemie L. Nicati, Samia Barriot, Laura Padayachy, Sébastien Tardy, Claudia Lukas, Fena Ochs, Sotirios K. Sotiriou, Vassilis G. Gorgoulis, Florian Huber, Konstantinos Evangelou, Natalia Lugli, Caterina Da-Ré, Irene Kamileri
Publikováno v:
Sotiriou, S K, Kamileri, I, Lugli, N, Evangelou, K, Da-Ré, C, Huber, F, Padayachy, L, Tardy, S, Nicati, N L, Barriot, S, Ochs, F, Lukas, C, Lukas, J, Gorgoulis, V, Scapozza, L & Halazonetis, T D 2016, ' Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks ', Molecular Cell, vol. 64, no. 6, pp. 1127-1134 . https://doi.org/10.1016/j.molcel.2016.10.038
Human cancers are characterized by the presence of oncogene-induced DNA replication stress (DRS), making them dependent on repair pathways such as break-induced replication (BIR) for damaged DNA replication forks. To better understand BIR, we perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924e3957d5c5c3d61a35859a38e71b66
Autor:
Fena Ochs, Maj-Britt Rask, Ezequiel Miron, Veronica J. Buckle, Lothar Schermelleh, Jill M. Brown, Jiri Lukas, Gopal Karemore, Hana Sedlackova, Marko Lampe, Claudia Lukas
Publikováno v:
Ochs, F, Karemore, G, Miron, E, Brown, J, Sedlackova, H, Rask, M-B, Lampe, M, Buckle, V, Schermelleh, L, Lukas, J & Lukas, C 2019, ' Stabilization of chromatin topology safeguards genome integrity ', Nature, vol. 574, no. 7779, pp. 571-574 . https://doi.org/10.1038/s41586-019-1659-4
To safeguard genome integrity in response to DNA double-strand breaks (DSBs), mammalian cells mobilize the neighbouring chromatin to shield DNA ends against excessive resection that could undermine repair fidelity and cause damage to healthy chromoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc78dd728e51219c615230411c69e824
https://ora.ox.ac.uk/objects/uuid:8f763984-002c-444d-a44c-d8f1d99d36e7
https://ora.ox.ac.uk/objects/uuid:8f763984-002c-444d-a44c-d8f1d99d36e7
Publikováno v:
Nature structural & molecular biology
Repair of DNA double-strand breaks (DSBs) in mammals is coordinated by the ubiquitin-dependent accumulation of 53BP1 at DSB-flanking chromatin. Owing to its ability to limit DNA-end processing, 53BP1 is thought to promote nonhomologous end-joining (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9db583893bcbb80f4ce6e48bf51f030
Autor:
Fena, Ochs, Gopal, Karemore, Ezequiel, Miron, Jill, Brown, Hana, Sedlackova, Maj-Britt, Rask, Marko, Lampe, Veronica, Buckle, Lothar, Schermelleh, Jiri, Lukas, Claudia, Lukas
Publikováno v:
Nature. 574(7779)
To safeguard genome integrity in response to DNA double-strand breaks (DSBs), mammalian cells mobilize the neighbouring chromatin to shield DNA ends against excessive resection that could undermine repair fidelity and cause damage to healthy chromoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c7b9153b8175306e1700889259974c0
https://pubmed.ncbi.nlm.nih.gov/31882194
https://pubmed.ncbi.nlm.nih.gov/31882194
Autor:
Kumar Somyajit, Rajat Gupta, Chunaram Choudhary, Fena Ochs, Maj-Britt Rask, Kai John Neelsen, Jiri Lukas, Hana Sedlackova
Publikováno v:
Science
Somyajit, K, Gupta, R, Sedlackova, H, Neelsen, K J, Ochs, F, Rask, M-B, Choudhary, C & Lukas, J 2017, ' Redox-sensitive alteration of replisome architecture safeguards genome integrity ', Science, vol. 358, no. 6364, pp. 797-802 . https://doi.org/10.1126/science.aao3172
Somyajit, K, Gupta, R, Sedlackova, H, Neelsen, K J, Ochs, F, Rask, M-B, Choudhary, C & Lukas, J 2017, ' Redox-sensitive alteration of replisome architecture safeguards genome integrity ', Science, vol. 358, no. 6364, pp. 797-802 . https://doi.org/10.1126/science.aao3172
Metabolic regulation of genome stability Cells respond to metabolic fluctuations by adjusting the speed of DNA replication as a safeguard for genome stability. Somyajit et al. elucidate the cellular mechanisms that align replication fork dynamics wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba024f174eeb6eaf2243daa6748a363