Výsledky vyhledávání - "Fen-Fen Soon"

Akademický článek

The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds.

Autor: Nanda Kumar Sasi, Kanchan Tiwari, Fen-Fen Soon, Dorine Bonte, Tong Wang, Karsten Melcher, H Eric Xu, Michael Weinreich

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e113300 (2014)

Cdc7-Dbf4 kinase or DDK (Dbf4-dependent kinase) is required to initiate DNA replication by phosphorylating and activating the replicative Mcm2-7 DNA helicase. DDK is overexpressed in many tumor cells and is an emerging chemotherapeutic target since D

Externí odkaz: https://doaj.org/article/5b2e67871d134f41aeaf944fb28e5ee8

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Akademický článek

The crystal structure of the orphan nuclear receptor NR2E3/PNR ligand binding domain reveals a dimeric auto-repressed conformation.

Autor: M H Eileen Tan, X Edward Zhou, Fen-Fen Soon, Xiaodan Li, Jun Li, Eu-Leong Yong, Karsten Melcher, H Eric Xu

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74359 (2013)

Photoreceptor-specific nuclear receptor (PNR, NR2E3) is a key transcriptional regulator of human photoreceptor differentiation and maintenance. Mutations in the NR2E3-encoding gene cause various retinal degenerations, including Enhanced S-cone syndro

Externí odkaz: https://doaj.org/article/b1a3c2cd8fac442983202b26f046f6c1

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Akademický článek

Abscisic acid signaling: thermal stability shift assays as tool to analyze hormone perception and signal transduction.

Autor: Fen-Fen Soon, Kelly M Suino-Powell, Jun Li, Eu-Leong Yong, H Eric Xu, Karsten Melcher

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47857 (2012)

Abscisic acid (ABA) is a plant hormone that plays important roles in growth and development. ABA is also the central regulator to protect plants against abiotic stresses, such as drought, high salinity, and adverse temperatures, and ABA signaling is

Externí odkaz: https://doaj.org/article/6ba313f778ca471e84e7618343526085

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Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases

Publikováno v: Science (New York, N.Y.). 335(6064)

Musical Chairs The plant hormone abscisic acid (ABA) helps plants to respond to changes in the environment, such as drought. Physiological responses are initiated when ABA binds to its receptor. In the absence of ABA, downstream kinases are held inac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101b6961364289c36aa69f30f0921d6a
https://pubmed.ncbi.nlm.nih.gov/22223797

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Thymoquinone Induces Telomere Shortening, DNA Damage and Apoptosis in Human Glioblastoma Cells

Autor: Aik Kia Khaw, M. Prakash Hande, Jasmine Fen Fen Soon, Safiyya Mohamed Ali, Rajamanickam Baskar, Manikandan Jayapal, Swaminathan Sethu, Resham L Gurung, Kirthan Shenoy, Shi Ni Lim

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 8, p e12124 (2010)

Background A major concern of cancer chemotherapy is the side effects caused by the non-specific targeting of both normal and cancerous cells by therapeutic drugs. Much emphasis has been placed on discovering new compounds that target tumour cells mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9db41f9c7e048a6db268863f5621f0
https://doi.org/10.1371/journal.pone.0012124

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