Zobrazeno 1 - 10
of 416
pro vyhledávání: '"Fen-Er Chen"'
Publikováno v:
Engineering, Vol 32, Iss , Pp 226-232 (2024)
Vitamin B1 is widely applied in the healthcare and food industry as an antineuritic and antioxidant to maintain the normal functioning of nerve conduction, the heart, and the gastrointestinal tract. This study reports on an integrated eight-step cont
Externí odkaz:
https://doaj.org/article/83990cfc0bda47719650681a2a166565
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 12, Pp 4906-4917 (2023)
Following on our recently developed biphenyl-ATDP non-nucleoside reverse transcriptase inhibitor ZLM-66 (SI = 2019.80, S = 1.9 μg/mL), a series of novel heterocycle-substituted ATDP derivatives with significantly improved selectivity and solubility
Externí odkaz:
https://doaj.org/article/9fc6b09d87c44d3a900c1f299690c817
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 7, Pp 3054-3066 (2023)
Considering the undesirable metabolic stability of our recently identified NNRTI 5 (t1/2 = 96 min) in human liver microsomes, we directed our efforts to improve its metabolic stability by introducing a new favorable hydroxymethyl side chain to the C-
Externí odkaz:
https://doaj.org/article/96af626d10184fe086ba06f1df9bc9ca
Autor:
Xuan-De Zhu, Angela Corona, Stefania Maloccu, Enzo Tramontano, Shuai Wang, Christophe Pannecouque, Erik De Clercq, Ge Meng, Fen-Er Chen
Publikováno v:
Molecules, Vol 29, Iss 9, p 2120 (2024)
Ribonuclease H (RNase H) was identified as an important target for HIV therapy. Currently, no RNase H inhibitors have reached clinical status. Herein, a series of novel thiazolone[3,2-a]pyrimidine-containing RNase H inhibitors were developed, based o
Externí odkaz:
https://doaj.org/article/4d4f54ff0ff54589865da65fa7714578
Publikováno v:
Molecules, Vol 29, Iss 9, p 2039 (2024)
Hydroformylation of olefins is widely used in the chemical industry due to its versatility and the ability to produce valuable aldehydes with 100% atom economy. Herein, a hybrid phosphate promoter was found to efficiently promote rhodium-catalyzed hy
Externí odkaz:
https://doaj.org/article/35fac8e80ecf4e27a90ea3b946e7257c
Publikováno v:
Green Synthesis and Catalysis, Vol 4, Iss 3, Pp 187-189 (2023)
A quantum-hydrogen-tunneling-controlled halogen-atom and group transfer strategy has been successfully developed to generate carbon radicals by using the substituted cyclohexadiene as the abstractor under mild photochemical conditions, in which alkyl
Externí odkaz:
https://doaj.org/article/cf77c95fa6644c9b8ebe1cfc63d07dd5
Publikováno v:
Engineering, Vol 21, Iss , Pp 92-100 (2023)
In this work, the nucleobase unit of the antiviral drug remdesivir, 7-bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, was synthesized through five-step continuous flow. By adapting batch synthetic chemistry, 7-bromopyrrolo[2,1-f][1,2,4]triazin-4-amine was
Externí odkaz:
https://doaj.org/article/a05926039f8a414ba0812121989d0ff4
Publikováno v:
Green Synthesis and Catalysis, Vol 3, Iss 3, Pp 219-226 (2022)
Due to high ring strain energies, cyclopropanols and cyclobutanols have a strong tendency of breaking the endocyclic C–C bonds to participate in versatile organic transformations. With an inherent three-dimensional structure, cyclopropanols and cyc
Externí odkaz:
https://doaj.org/article/5e5ffc6d254248b6844417ad7354a16f
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 6, Pp 2790-2807 (2022)
Cyclooxygenases play a vital role in inflammation and are responsible for the production of prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2, for which the target inhibitors are t
Externí odkaz:
https://doaj.org/article/12b8aeda1c954fd7af28c27581012726
Publikováno v:
Green Synthesis and Catalysis, Vol 2, Iss 4, Pp 329-336 (2021)
The introduction of new interactions into organic transformation is an objective of fundamental importance. Chalcogen bond has emerged as an unconventional type of noncovalent interaction which provides a useful synthetic tool for organocatalysis and
Externí odkaz:
https://doaj.org/article/acf62b0846414eb492ca2667c7043e53