Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Fen Hwa Wong"'
Publikováno v:
Annals of Plastic Surgery. 82:S23-S28
Background Cleft lip/palate is a congenital craniofacial anomaly affecting patients physically and psychosocially and has contributed to the global burden of surgical disease, especially in underprivileged areas. For 20 years, Noordhoff Craniofacial
Publikováno v:
Science Signaling. 12
Cleft palate is a common craniofacial defect caused by a failure in palate fusion. The palatal shelves migrate toward one another and meet at the embryonic midline, creating a seam. Transforming growth factor-β3 (TGF-β3)-induced apoptosis of the me
Autor:
Chang Tze Ricky Yu, Li Jen Su, Shih-Lan Hsu, Jin Mei Lai, Wey Jinq Lin, Fen Hwa Wong, Yow-Ling Shiue, Jiunn Chyi Wu, Su Liang Chen, Chi Ying F. Huang, Yong Shiang Lin, Hsu Hua Yeh, Hsiao Sheng Liu
The evolutionarily conserved Aurora family kinases, a family of mitotic serine/threonine kinases, has three members in humans (Aurora-A, -B and -C). Overexpression of Aurora family members, particularly Aurora-A, has been reported in many human cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c1da3e9914a3072729102231b9627e
https://europepmc.org/articles/PMC6032448/
https://europepmc.org/articles/PMC6032448/
Publikováno v:
The Cleft Palate-Craniofacial Journal. 51:729-734
Kabuki syndrome (KS) is a multiple congenital anomaly/mental retardation syndrome with characteristic facial features. Despite more than 350 documented cases and recent correlation of MLL2 mutations as a genetic cause, its full clinical spectrum is s
Autor:
Tung Chao, Ling Chien Hung, Cheng Deng Kuo, Chao Hsiung Lin, Chun-Cheng Lin, Li De Huang, Shu Ling Fu, Yong Shiang Lin, Fen Hwa Wong
Publikováno v:
Biochemical Pharmacology. 86:242-252
Activation of Toll-like receptor 4 (TLR4) triggers both innate and adaptive immunity. We previously identified a synthetic glycolipid, CCL-34, which can induce anticancer immunity in a TLR4-dependent manner. In the present study, we demonstrated the
Autor:
Yu Jen Chen, Chao Hsiung Lin, Li De Huang, Po Hsiung Huang, Shu Ling Fu, Chun-Cheng Lin, Yong Shiang Lin, Fen Hwa Wong
Publikováno v:
Journal of Biological Chemistry. 286:43782-43792
Activation of Toll-like receptor 4 (TLR4) triggers the innate immune response and leads to the induction of adaptive immunity. TLR4 agonists are known to function as immunostimulants and exhibit promising therapeutic potential for cancer immunotherap
Autor:
Wen Cheng Chou, Chen-Yang Shen, Fen Hwa Wong, Pei Ei Wu, Sheau-Yann Shieh, Hui-Chun Wang, Shian Ling Ding
Publikováno v:
The EMBO Journal. 27:3140-3150
The DNA damage response (DDR) has an essential function in maintaining genomic stability. Ataxia telangiectasia-mutated (ATM)-checkpoint kinase 2 (Chk2) and ATM- and Rad3-related (ATR)-Chk1, triggered, respectively, by DNA double-strand breaks and bl
Publikováno v:
Scientific Reports
Mutation in interferon regulatory factor 6 (IRF6) is known to cause syndromic and non-syndromic cleft lip/palate in human. In this study, we investigated the molecular mechanisms related to IRF6 during palatal fusion using palatal shelves organ cultu
Autor:
Junn Liang Chang, Chia Fang Wang, Ting Hsuan Chen, Chen-Kung Chou, Ya Ling Huang, Chun Ming Chen, Fen Hwa Wong, Yi Hsuan Chiang
Publikováno v:
Experimental Cell Research. 312:962-973
Chromosomal passenger proteins including Aurora B, Survivin, and Borealin/Dasra B, also called CDCA8/FLJ10468, are known to play crucial roles during mitosis and cell division. Inappropriate chromosomal segregation and cell division may cause auneupl
Autor:
Ann-Joy Cheng, Joseph Tung-Chieh Chang, Chun-Ta Liao, I-How Chen, Hung-Ming Wang, Fen-Hwa Wong
Publikováno v:
Clinical Chemistry. 50:1261-1264
Several proteins associated with malignant transformation of cells can induce autoantibodies (1)(2)(3)(4). These autoantibodies, such as those to p53, are detectable in serum and may serve to monitor tumor progression (4)(5). Survivin, a recently clo