Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Fen Fen Lin"'
Publikováno v:
Inorganic and Nano-Metal Chemistry. :1-6
Autor:
Les P. Miranda, Ching Chen, Irwin Chen, Philip Jess, Aaron George Winters, Christopher Tan, Ming C. Wu, Philip Tagari, Fen-Fen Lin, Agi Hamburger, Jennitte Stevens, Marissa Mock, J. Tanner Nevill, Trent P. Munro, Su Chong, Kim Le, Marsela Jorgolli, Han Xu
Publikováno v:
Biotechnology and bioengineering, vol 116, iss 9
Biotechnology and Bioengineering
Biotechnology and Bioengineering
The new and rapid advancement in the complexity of biologics drug discovery has been driven by a deeper understanding of biological systems combined with innovative new therapeutic modalities, paving the way to breakthrough therapies for previously i
Steroids up-regulate p66Shc longevity protein in growth regulation by inhibiting its ubiquitination.
Autor:
Santosh Kumar, Satyendra Kumar, Mythilypriya Rajendran, Syed Mahfuzul Alam, Fen-Fen Lin, Pi-Wan Cheng, Ming-Fong Lin
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15942 (2011)
p66Shc, an isoform of Shc adaptor proteins, mediates diverse signals, including cellular stress and mouse longevity. p66Shc protein level is elevated in several carcinomas and steroid-treated human cancer cells. Several lines of evidence indicate tha
Externí odkaz:
https://doaj.org/article/b998d81934f644f0b24d802735e67f76
Autor:
Marsela Jorgolli, Tanner Nevill, Aaron Winters, Irwin Chen, Su Chong, Fen‐Fen Lin, Marissa Mock, Ching Chen, Kim Le, Christopher Tan, Philip Jess, Han Xu, Agi Hamburger, Jennitte Stevens, Trent Munro, Ming Wu, Philip Tagari, Les P. Miranda
Publikováno v:
Biotechnology and Bioengineering. 116
Autor:
Dannah R, Miller, Matthew A, Ingersoll, Yu-Wei, Chou, C Brent, Wakefield, Yaping, Tu, Fen-Fen, Lin, William G, Chaney, Ming-Fong, Lin
Publikováno v:
Journal of oncology research and therapy. 3(5)
The treatment of castration-resistant (CR) prostate cancer (PCa) is limited. A sub-population of CR PCa tumors can synthesize androgens for intracrine androgen receptor (AR) activation, thus targeting androgen biosynthesis could be an effective thera
Autor:
Yu-Wei Chou1,2 ywchou@cgmh.org.tw, Fen-Fen Lin2, Muniyan, Sakthivel2, Lin, Frank C.2,3, Ching-Shih Chen4, Jue Wang5,6, Chao-Cheng Huang1,7, Ming-Fong Lin2,8,9,10 mlin@unmc.edu
Publikováno v:
Cell & Bioscience. Jul2015, Vol. 5 Issue 1, p1-9. 9p.
Autor:
Joseph Ligutti, Les P. Miranda, Fen-Fen Lin, Shi-Yuan Meng, Anruo Zou, Stefan I. McDonough, Kaustav Biswas, Dong Liu, Kristin L. Andrews, Bryan D. Moyer, J. Ryan Holder, Justin K. Murray, Leszek Poppe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4866-4871
Many efforts are underway to develop selective inhibitors of the voltage-gated sodium channel Na V 1.7 as new analgesics. Thus far, however, in vitro selectivity has proved difficult for small molecules, and peptides generally lack appropriate pharma
Autor:
L. DeEtte Walker, Yu Wei Chou, Subodh M. Lele, Te Jung Tsai, Benedict B. Benigno, Shafiq A. Khan, Sakthivel Muniyan, John F. McDonald, Fen Fen Lin, Ming Fong Lin, Paul G. Thomes, Suresh Veeramani
Publikováno v:
Molecular Carcinogenesis. 54:618-631
p66Shc functions as a longevity protein in murine and exhibits oxidase activity in regulating diverse biological activities. In this study, we investigated the role of p66Shc protein in regulating ovarian cancer (OCa) cell proliferation. Among three
Autor:
Surinder K. Batra, Fen Fen Lin, Li Zhang, Ralph J. Hauke, Rachel Schutte, Thomas L. Davis, Ming Fong Lin, Stanislav Zelivianski, Jeffrey S. Davis
Publikováno v:
Cancer Letters. 285:58-65
We examined the efficacy of combination treatments utilizing cytotoxic drugs plus inhibitors to members of the ErbB - ERK signal pathway in human prostate cancer (PCa) LNCaP C-81 cells. Under an androgen-reduced condition, 50 nM gemcitabine caused ab
Autor:
Ryan White, James Brown, Jean-Christophe Harmange, Xiaoyang Xia, Josie Han Lee, Yuan Cheng, Robert T. Fremeau, Beth J. Hoffman, Susan A. Tomlinson, Matthew W. Martin, Liyue Huang, Erin F. DiMauro, Stephen Hitchcock, Hung Q. Nguyen, John L. Buchanan, Vinod F. Patel, Ming Huang, William H. Buckner, Brian K. Albrecht, Fen-Fen Lin, Renee Emkey
Publikováno v:
Journal of Medicinal Chemistry. 51:5019-5034
The CB2 receptor is an attractive therapeutic target for analgesic and anti-inflammatory agents. Herein we describe the discovery of a novel class of oxadiazole derivatives from which potent and selective CB2 agonist leads were developed. Initial hit