Zobrazeno 1 - 10
of 1 388
pro vyhledávání: '"Fen Chang"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background The cellular origin of hypopharyngeal diseases is crucial for further diagnosis and treatment, and the microenvironment in tissues may also be associated with specific cell types at the same time. Normal adjacent tissues (NATs) of
Externí odkaz:
https://doaj.org/article/a503c5a5f5fe4e07978e81b7de81fb28
Autor:
Xueyuan Guo, Yanfang Ma, Ting Zhang, Runyu Liu, Fen Chang, Xingyue Yan, Tianyun Yu, Pengfei Wu, Qin Li, Luzheng Xu, Junyi Duan, Li Li, Yanrong Su, Genze Shao
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract BRCA1 plays a suppressive role in breast tumorigenesis. Ubiquitin-dependent degradation is a common mechanism that regulates BRCA1 protein stability, and several ubiquitin ligases involved have been identified. However, the deubiquitinating
Externí odkaz:
https://doaj.org/article/4b142915c92d458fbd4b88c70a11f05a
Autor:
Ce Li, Rui Guan, Wenming Li, Dongmin Wei, Shengda Cao, Fen Chang, Qun Wei, Ran Wei, Long Chen, Chenyang Xu, Kainan Wu, Dapeng Lei
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Head neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors which ranks the sixth incidence in the world. Although treatments for HNSCC have improved significantly in recent years, its recurrence rate and mortality r
Externí odkaz:
https://doaj.org/article/0ab7583b42d44a29b1c62b80f04f07cb
Autor:
Junyi Duan, Daoyuan Huang, Cheng Liu, Yangbo Lv, Lei Zhang, Fen Chang, Xiangyu Zeng, Li Li, Weiping Wang, Genze Shao
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-15 (2023)
Abstract Ferroptosis is an iron-dependent form of regulated cell death characterized by lipid peroxidation. Colorectal cancer (CRC) cells evade ferroptosis despite their requirement of substantial iron and reactive oxygen species (ROS) to sustain act
Externí odkaz:
https://doaj.org/article/2b925fb1cd0e4d19a980de5c6c7fd7f7
Autor:
Qin Li, Yanfang Ma, Fen Chang, Yongjie Xu, Jingcheng Deng, Junyi Duan, Wei Jiang, Qihua He, Luzheng Xu, Lijun Zhong, Genze Shao, Li Li
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
The BRCC36 isopeptidase complex (BRISC) is identified as the deubiquitinating enzyme for Lys63-linked ubiquitination of Aurora B, and hyperactivated Aurora B in the absence of BRISC leads to erroneous chromosome–microtubule attachment during mitosi
Externí odkaz:
https://doaj.org/article/3dab4287fcfb4bd187bd12194cafb1d0
Autor:
Ce Li, Rui Guan, Wenming Li, Dongmin Wei, Shengda Cao, Chenyang Xu, Fen Chang, Pin Wang, Long Chen, Dapeng Lei
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundHuman hypopharygeal squamous cell carcinoma (HSCC) is a common head and neck cancer with a poor prognosis in advanced stages. The occurrence and development of tumor is the result of mutual influence and co-evolution between tumor cells and
Externí odkaz:
https://doaj.org/article/7596f4d748354a54b9593eb7290b9b0b
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundHypopharyngeal squamous cell cancer (HSCC) is one of the most malignant tumors of the head and neck. It is not easy to detect in the early stage due to its hidden location; thus, lymph node metastasis is highly likely at diagnosis, leading
Externí odkaz:
https://doaj.org/article/6b720529fb894021996d4d3e5bbea569
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IGF2BPs belongs to a family of conserved RNA-bound oncoembryonic proteins that play a crucial part in various aspects of cell function, such as cell migration, morphology, metabolism, proliferation and differentiation. Recent studies have shown that
Externí odkaz:
https://doaj.org/article/70bcc5da0fad428fbc36880fcafbcecc
Autor:
Yongjie Xu, Yumeng Hu, Tao Xu, Kaowen Yan, Ting Zhang, Qin Li, Fen Chang, Xueyuan Guo, Jingyu Peng, Mo Li, Min Zhao, Hongying Zhen, Luzheng Xu, Duo Zheng, Li Li, Genze Shao
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109854- (2021)
Summary: Despite the tremendous success of targeted and conventional therapies for lung cancer, therapeutic resistance is a common and major clinical challenge. RNF8 is a ubiquitin E3 ligase that plays essential roles in the DNA damage response; howe
Externí odkaz:
https://doaj.org/article/eb9f97f9ca6940cdb3d5cc14ca584de7
Bioinformatics analysis of the structural and evolutionary characteristics for toll-like receptor 15
Publikováno v:
PeerJ, Vol 4, p e2079 (2016)
Toll-like receptors (TLRs) play important role in the innate immune system. TLR15 is reported to have a unique role in defense against pathogens, but its structural and evolution characterizations are still poorly understood. In this study, we identi
Externí odkaz:
https://doaj.org/article/19a2584c53234579a9abf9624d10922e