Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Femke Ringnalda"'
Autor:
Christian K. Hirt, Tijmen H. Booij, Linda Grob, Patrik Simmler, Nora C. Toussaint, David Keller, Doreen Taube, Vanessa Ludwig, Alexander Goryachkin, Chantal Pauli, Daniela Lenggenhager, Daniel J. Stekhoven, Christian U. Stirnimann, Katharina Endhardt, Femke Ringnalda, Lukas Villiger, Alexander Siebenhüner, Sofia Karkampouna, Marta De Menna, Janette Beshay, Hagen Klett, Marianna Kruithof-de Julio, Julia Schüler, Gerald Schwank
Publikováno v:
Cell Genomics, Vol 2, Iss 2, Pp 100095- (2022)
Summary: Pancreatic cancer (PDAC) is a highly aggressive malignancy for which the identification of novel therapies is urgently needed. Here, we establish a human PDAC organoid biobank from 31 genetically distinct lines, covering a representative ran
Externí odkaz:
https://doaj.org/article/528029a5e0b440e9b617944420259540
Autor:
Cindy J.M. Loomans, Nerys Williams Giuliani, Jeetindra Balak, Femke Ringnalda, Léon van Gurp, Meritxell Huch, Sylvia F. Boj, Toshiro Sato, Lennart Kester, Susana M. Chuva de Sousa Lopes, Matthias S. Roost, Susan Bonner-Weir, Marten A. Engelse, Ton J. Rabelink, Harry Heimberg, Robert G.J. Vries, Alexander van Oudenaarden, Françoise Carlotti, Hans Clevers, Eelco J.P. de Koning
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 712-724 (2018)
Summary: Generating an unlimited source of human insulin-producing cells is a prerequisite to advance β cell replacement therapy for diabetes. Here, we describe a 3D culture system that supports the expansion of adult human pancreatic tissue and the
Externí odkaz:
https://doaj.org/article/26dfd9d03dab480b970ce0861845e50f
Autor:
Margit Bleijs, Corine Pleijte, Sem Engels, Femke Ringnalda, Friederike Meyer-Wentrup, Marc van de Wetering, Hans Clevers
Publikováno v:
Cancers, Vol 13, Iss 23, p 6072 (2021)
Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive soft tissue sarcoma with a lack of effective treatment options and a poor prognosis. DSRCT is characterized by a chromosomal translocation, resulting in the EWSR1-WT1 gene fusion. T
Externí odkaz:
https://doaj.org/article/4f125b20f6504fc19b41769dfc49d1f3
Autor:
Nataša Savić, Femke Ringnalda, Christian Berk, Katja Bargsten, Jonathan Hall, Martin Jinek, Gerald Schwank
Publikováno v:
Bio-Protocol, Vol 9, Iss 1 (2019)
The CRISPR-Cas9 system is a powerful genome-editing tool that promises application for gene editing therapies. The Cas9 nuclease is directed to the DNA by a programmable single guide (sg)RNA, and introduces a site-specific double-stranded break (DSB)
Externí odkaz:
https://doaj.org/article/80bd18ded89e4594baf98888bc784009
Autor:
Irene Paassen, Justin Williams, Carla Ríos Arceo, Femke Ringnalda, Kimberly Shea Mercer, Juliane L. Buhl, Natalia Moreno, Aniello Federico, Niels E. Franke, Mariette Kranendonk, Santhosh A. Upadhyaya, Kornelius Kerl, Marc van de Wetering, Hans Clevers, Marcel Kool, Eelco W. Hoving, Martine F. Roussel, Jarno Drost
Publikováno v:
Oncogene. 42:1661-1671
Atypical teratoid/rhabdoid tumors (ATRTs) represent a rare, but aggressive pediatric brain tumor entity. They are genetically defined by alterations in the SWI/SNF chromatin remodeling complex members SMARCB1 or SMARCA4. ATRTs can be further classifi
Autor:
Jonas Seiler, Marin T Mondria, Irena Bockaj, Marcel A. T. M. van Vugt, Bjorn Bakker, Diana C.J. Spierings, Femke Ringnalda, Saskia L Meuleman, Mathilde J.C. Broekhuis, Ulrich Schüller, Floris Foijer, Hans Clevers, Colin Stok, Tosca. E. I. Martini, Eduardo Sabino de Camargo Magalhães, Hilda van den Bos, Yannick P Kok, Tiny G. J. Meeuwsen-de Boer, Inna Armandari, René Wardenaar, Petra L. Bakker, Sophia W.M. Bruggeman
Publikováno v:
PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics, 17(11). Public Library of Science
PLoS genetics, 17(11):1009868. PUBLIC LIBRARY SCIENCE
PLoS Genetics, Vol 17, Iss 11, p e1009868 (2021)
Bočkaj, I, Martini, T E I, de Camargo Magalhães, E S, Bakker, P L, Meeuwsen-de Boer, T G J, Armandari, I, Meuleman, S L, Mondria, M T, Stok, C, Kok, Y P, Bakker, B, Wardenaar, R, Seiler, J, Broekhuis, M J C, van den Bos, H, Spierings, D C J, Ringnalda, F C A, Clevers, H, Schüller, U, van Vugt, M A T M, Foijer, F & Bruggeman, S W M 2021, ' The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma ', PLoS Genetics, vol. 17, no. 11, e1009868, pp. e1009868 . https://doi.org/10.1371/journal.pgen.1009868
PLoS Genetics, 17(11):e1009868. Public Library of Science
PLoS Genetics
PLoS Genetics, 17(11). Public Library of Science
PLoS genetics, 17(11):1009868. PUBLIC LIBRARY SCIENCE
PLoS Genetics, Vol 17, Iss 11, p e1009868 (2021)
Bočkaj, I, Martini, T E I, de Camargo Magalhães, E S, Bakker, P L, Meeuwsen-de Boer, T G J, Armandari, I, Meuleman, S L, Mondria, M T, Stok, C, Kok, Y P, Bakker, B, Wardenaar, R, Seiler, J, Broekhuis, M J C, van den Bos, H, Spierings, D C J, Ringnalda, F C A, Clevers, H, Schüller, U, van Vugt, M A T M, Foijer, F & Bruggeman, S W M 2021, ' The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma ', PLoS Genetics, vol. 17, no. 11, e1009868, pp. e1009868 . https://doi.org/10.1371/journal.pgen.1009868
PLoS Genetics, 17(11):e1009868. Public Library of Science
PLoS Genetics
While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliom
Autor:
Femke Ringnalda, Gerald Schwank, Hiu Man Grisch-Chan, Johannes Häberle, Beat Thöny, Lukas Villiger, Joao Matos, Ralph Fingerhut, Mark D. Robinson, Helen Lindsay, Gabriella Allegri, Chiara Balbo Pogliano
Publikováno v:
Nature Medicine. 24:1519-1525
CRISPR-Cas-based genome editing holds great promise for targeting genetic disorders, including inborn errors of hepatocyte metabolism. Precise correction of disease-causing mutations in adult tissues in vivo, however, is challenging. It requires repa
Autor:
Lukas Villiger, Ruben van Boxtel, Beat Thöny, Christian Berk, Sharan Janjuha, Dominik Witzigmann, Hubert Rehrauer, Paulo J.C. Lin, Jonathan Hall, Gerald Schwank, Mitchell B. Beattie, Markus Stoffel, Tanja Rothgangl, Ying K. Tam, Weihong Qi, Rurika Oka, Femke Ringnalda
Publikováno v:
Nature Biomedical Engineering, 5 (2)
Nature biomedical engineering
Nature biomedical engineering
Base editors are RNA-programmable deaminases that enable precise single-base conversions in genomic DNA. However, off-target activity is a concern in the potential use of base editors to treat genetic diseases. Here, we report unbiased analyses of tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4989e2659cf5259129c705aa94d58bb8
https://hdl.handle.net/20.500.11850/462202
https://hdl.handle.net/20.500.11850/462202
Autor:
Christian Berk, Jonathan Hall, Gerald Schwank, Natasa Savic, Martin Jinek, Femke Ringnalda, Katja Bargsten
The CRISPR-Cas9 system is a powerful genome-editing tool that promises application for gene editing therapies. The Cas9 nuclease is directed to the DNA by a programmable single guide (sg)RNA, and introduces a site-specific double-stranded break (DSB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5cba8b3488fdc02002a560c08db945a
https://www.zora.uzh.ch/id/eprint/174011/
https://www.zora.uzh.ch/id/eprint/174011/
Autor:
Nicolas Broguiere, Till Ringel, Emma Cavalli, Julia Schüler, Luca Isenmann, Gerald Schwank, Christian Hirt, Roger Lehmann, Femke Ringnalda, Marcy Zenobi-Wong, Gerhard Rogler, Markus H. Heim, Richard Züllig, Silja Placzek, Lukas Villiger
Publikováno v:
Advanced Materials, 30 (43)
Epithelial organoids are simplified models of organs grown in vitro from embryonic and adult stem cells. They are widely used to study organ development and disease, and enable drug screening in patient‐derived primary tissues. Current protocols, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d444014b0429ebfd6757cf7218238100
https://hdl.handle.net/20.500.11850/302457
https://hdl.handle.net/20.500.11850/302457