Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Femke Heindryckx"'
Autor:
Maria Kopsida, Ada Lerma Clavero, Jaafar Khaled, David Balgoma, Clara Luna-Marco, Azazul Chowdhury, Sofi Sennefelt Nyman, Fredrik Rorsman, Charlotte Ebeling Barbier, Peter Bergsten, Hans Lennernäs, Mikael Hedeland, Femke Heindryckx
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101846- (2024)
Hepatocellular carcinoma (HCC) is characterized by a low and variable response to chemotherapeutic treatments. One contributing factor to the overall pharmacodynamics is the activation of endoplasmic reticulum (ER) stress pathways. This is a cellular
Externí odkaz:
https://doaj.org/article/a28070bb6a72401c97ac140010fab73d
Autor:
Carlemi Calitz, Jenny Rosenquist, Oliver Degerstedt, Jaafar Khaled, Maria Kopsida, Mårten Fryknäs, Hans Lennernäs, Ayan Samanta, Femke Heindryckx
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The tumor micro-environment (TME) of hepatocellular carcinoma (HCC) consists out of cirrhotic liver tissue and is characterized by an extensive deposition of extracellular matrix proteins (ECM). The evolution from a reversible fibrotic state
Externí odkaz:
https://doaj.org/article/1e1dc03c15a04103b200d6c8b042d2a9
Autor:
Fredrik Rorsman, Ulrika S H Simonsson, Håkan Ahlström, Sofi Sennefelt Nyman, Angeliki Dimopoulou Creusen, David Dahlgren, Mikael Hedeland, Femke Heindryckx, Ulf Johnson, Jaafar Khaled, Fredrik Kullenberg, Rickard Nyman, Reza Sheikhi, Erik Sjögren, Alkwin Wanders, Hans Lennernäs, Charlotte Ebeling Barbier
Publikováno v:
BMJ Open, Vol 12, Iss 11 (2022)
Introduction Hepatocellular carcinoma (HCC) is a common cause of cancer-related death, often detected in the intermediate stage. The standard of care for intermediate-stage HCC is transarterial chemoembolisation (TACE), where idarubicin (IDA) is a pr
Externí odkaz:
https://doaj.org/article/7c7c91e342a24d6c8b67d590e1e651b2
Autor:
David Balgoma, Fredrik Kullenberg, Karsten Peters, David Dahlgren, Femke Heindryckx, Hans Lennernäs, Mikael Hedeland
Publikováno v:
Metabolites, Vol 12, Iss 9, p 866 (2022)
Ad libitum feeding of experimental animals is preferred because of medical relevance together with technical and practical considerations. In addition, ethical committees may require ad libitum feeding. However, feeding affects the metabolism so ad l
Externí odkaz:
https://doaj.org/article/b796cac483c148ec8ada85f1173c28ac
Autor:
Nataša Pavlović, Carlemi Calitz, Kess Thanapirom, Guiseppe Mazza, Krista Rombouts, Pär Gerwins, Femke Heindryckx
Publikováno v:
eLife, Vol 9 (2020)
Hepatocellular carcinoma (HCC) is a liver tumor that usually arises in patients with cirrhosis. Hepatic stellate cells are key players in the progression of HCC, as they create a fibrotic micro-environment and produce growth factors and cytokines tha
Externí odkaz:
https://doaj.org/article/b5d67512ef7e4c37989d995e284c868e
Publikováno v:
Cells, Vol 11, Iss 4, p 632 (2022)
Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers worldwide. It is usually diagnosed in an advanced stage and is characterized by a high intrinsic drug resistance, leading to limited chemotherapeutic efficacy and relapse aft
Externí odkaz:
https://doaj.org/article/0d69972db6a7442a8db21c7ec6072583
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 13051 (2021)
Because diagnostic tools for discriminating between hepatocellular carcinoma (HCC) and advanced cirrhosis are poor, HCC is often detected in a stage where transarterial chemoembolization (TACE) is the best treatment option, even though it provides a
Externí odkaz:
https://doaj.org/article/bf6865e4921d4af8881a173fa8026291
Autor:
Nataša Pavlović, Femke Heindryckx
Publikováno v:
Biology, Vol 10, Iss 7, p 640 (2021)
Endoplasmic reticulum (ER) stress and actors of unfolded protein response (UPR) have emerged as key hallmarks of hepatocarcinogenesis. Numerous reports have shown that the main actors in the UPR pathways are upregulated in HCC and contribute to the d
Externí odkaz:
https://doaj.org/article/76172c011ef84247a0859c99cddcd4b2
Autor:
Fredrik Kullenberg, Oliver Degerstedt, Carlemi Calitz, Nataša Pavlović, David Balgoma, Johan Gråsjö, Erik Sjögren, Mikael Hedeland, Femke Heindryckx, Hans Lennernäs
Publikováno v:
Cells, Vol 10, Iss 7, p 1717 (2021)
Cytostatic effects of doxorubicin in clinically applied doses are often inadequate and limited by systemic toxicity. The main objective of this in vitro study was to determine the anti-tumoral effect (IC50) and intracellular accumulation of free and
Externí odkaz:
https://doaj.org/article/0957576a8afc4411ac977d7f636e642b
Autor:
David Balgoma, Fredrik Kullenberg, Carlemi Calitz, Maria Kopsida, Femke Heindryckx, Hans Lennernäs, Mikael Hedeland
Publikováno v:
Cells, Vol 10, Iss 5, p 1163 (2021)
Metabolic and personalized interventions in cancer treatment require a better understanding of the relationship between the induction of cell death and metabolism. Consequently, we treated three primary liver cancer cell lines with two anthracyclins
Externí odkaz:
https://doaj.org/article/6a0ea0d915bc4537b4110c7deff952c5