MEK1/2 Inhibition in Murine Heart and Aorta After Oral Administration of Refametinib Supplemented Drinking Water

Autor: Felke Steijns, Nathalie Bracke, Marjolijn Renard, Julie De Backer, Patrick Sips, Nathan Debunne, Evelien Wynendaele, Frederick Verbeke, Bart De Spiegeleer, Laurence Campens

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

Upregulation of the RAS-RAF-MEK-ERK-MAPK pathway is involved in the development of several human tumors, aortic aneurysms, atherosclerosis, and cardiomyopathy. Refametinib, a highly selective MEK-inhibitor, has already shown antineoplastic activity i

Externí odkaz: https://doaj.org/article/3ef60489e3fc45979fff017a2792931f

Spontaneous Right Ventricular Pseudoaneurysms and Increased Arrhythmogenicity in a Mouse Model of Marfan Syndrome

Autor: Marjolijn Renard, Robrecht Raedt, Patrick Sips, Lars Emil Larsen, Felke Steijns, Julie De Backer, Petra Vermassen, Marine Vanhomwegen, Máté István Tóth, Jana Desloovere

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 19
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
International Journal of Molecular Sciences, Vol 21, Iss 7024, p 7024 (2020)

Patients with Marfan syndrome (MFS), a connective tissue disorder caused by pathogenic variants in the gene encoding the extracellular matrix protein fibrillin-1, have an increased prevalence of primary cardiomyopathy, arrhythmias, and sudden cardiac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da48d3d3b7b7ad2a9f40fadacf510e36
https://pubmed.ncbi.nlm.nih.gov/32987703

Tailoring the American College of Medical Genetics and Genomics and the Association for Molecular Pathology Guidelines for the Interpretation of Sequenced Variants in the FBN1 Gene for Marfan Syndrome

Autor: Felke Steijns, Tjorven Audenaert, Wouter Steyaert, Paul Coucke, Julie De Backer, Ilse Meerschaut, Bert Callewaert, Sofie Symoens, Marjolijn Renard, Laura Muiño-Mosquera, Anne De Paepe

Publikováno v: Circulation: Genomic and Precision Medicine. 11

Background:The introduction of next-generation sequencing techniques has substantially increased the identification of new genetic variants and hence the necessity of accurate variant interpretatio...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41fcead89338e02bd070389b8614a9b9
https://doi.org/10.1161/circgen.117.002039

Ambulatory Electrocardiographic Monitoring and Ectopic Beat Detection in Conscious Mice

Autor: Marjolijn Renard, Robrecht Raedt, Patrick Sips, Julie De Backer, Lars Emil Larsen, Máté István Tóth, Patrick Segers, Felke Steijns, Jana Desloovere, Anthony Demolder

Publikováno v: Sensors, Vol 20, Iss 3867, p 3867 (2020)
SENSORS
Sensors (Basel, Switzerland)
Sensors
Volume 20
Issue 14

Ambulatory electrocardiography (AECG) is a primary diagnostic tool in patients with potential arrhythmic disorders. To study the pathophysiological mechanisms of arrhythmic disorders, mouse models are widely implemented. The use of a technique simila

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852dd72f694d6541b6606c428a25b345