Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Felix von-Zweydorf"'
Autor:
Jorge Garcia Morato, Friederike Hans, Felix von Zweydorf, Regina Feederle, Simon J. Elsässer, Angelos A. Skodras, Christian Johannes Gloeckner, Emanuele Buratti, Manuela Neumann, Philipp J. Kahle
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
TDP-43 is a nucleic acid binding protein, whose insoluble aggregates are neuropathological hallmarks of specific subsets of patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Post-translational modifications and acetyl
Externí odkaz:
https://doaj.org/article/5d612ba76c204e148f11afe0e162e337
Autor:
Michael Dietachmayr, Abirami Rathakrishnan, Oleksandra Karpiuk, Felix von Zweydorf, Thomas Engleitner, Vanesa Fernández-Sáiz, Petra Schenk, Marius Ueffing, Roland Rad, Martin Eilers, Christian Johannes Gloeckner, Katharina Clemm von Hohenberg, Florian Bassermann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
In yeast, the phosphatase Cdc14 controls mitotic exit. Here the authors show that mammalian CDC14B antagonizes CDK1, to keep the deubiquitinase USP9X unphosphorylated and inactive, and that Wilms’ tumor protein 1 is a substrate for active USP9X tha
Externí odkaz:
https://doaj.org/article/bd16efa5decb42a998a0892197a13545
Autor:
Maria Dolores Perez Carrion, Silvia Marsicano, Federica Daniele, Antonella Marte, Francesca Pischedda, Eliana Di Cairano, Ester Piovesana, Felix von Zweydorf, Elisabeth Kremmer, Christian Johannes Gloeckner, Franco Onofri, Carla Perego, Giovanni Piccoli
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Mutations in the Leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial Parkinson’s disease (PD). LRRK2 protein contains several functional domains, including protein-protein interaction domains at its N- and C-termini. In
Externí odkaz:
https://doaj.org/article/80d9facf1fc1460aa75b5282c4e64bdf
Autor:
Elli-Anna Balta, Marie-Theres Wittmann, Matthias Jung, Elisabeth Sock, Benjamin Martin Haeberle, Birgit Heim, Felix von Zweydorf, Jana Heppt, Julia von Wittgenstein, Christian Johannes Gloeckner, Dieter Chichung Lie
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
SOX11 is a key Transcription Factor (TF) in the regulation of embryonic and adult neurogenesis, whose mutation has recently been linked to an intellectual disability syndrome in humans. SOX11’s transient activity during neurogenesis is critical to
Externí odkaz:
https://doaj.org/article/06b6ae3ed48449bc90521010c660342c
Autor:
Ranjan K. Singh, Ahmed Soliman, Giambattista Guaitoli, Eliza Störmer, Felix von Zweydorf, Thomas Dal Maso, Asmaa Oun, Laura Van Rillaer, Sven H. Schmidt, Deep Chatterjee, Joshua A. David, Els Pardon, Thomas U. Schwartz, Stefan Knapp, Eileen J. Kennedy, Jan Steyaert, Friedrich W. Herberg, Arjan Kortholt, Christian Johannes Gloeckner, Wim Versées
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 119(9):e2112712119. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America 119(9), e2112712119 (2022). doi:10.1073/pnas.2112712119
Proceedings of the National Academy of Sciences of the United States of America 119(9), e2112712119 (2022). doi:10.1073/pnas.2112712119
Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) are a leading cause of the inherited form of Parkinson's disease (PD), while LRRK2 overactivation is also associated with the more common idiopathic form of PD. LRRK2 is a large mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec9137a034b6629ae019cb5b5d3957f
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/98457
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/98457
Autor:
Leah G. Helton, Panagiotis S Athanasopoulos, Bernd K Gilsbach, Scotty Hall, Ranjan Kumar Singh, Ahmed Soliman, Hardy J. Rideout, Felix von Zweydorf, Christian Johannes Gloeckner, Francesco Raimondi, Franz Y. Ho, Eileen J. Kennedy, Arjan Kortholt, Jascha Tobias Manschwetus, Timothy J LeClair, Friedrich W. Herberg, Wim Versées, Michalis Kentros
Publikováno v:
ACS chemical biology 16(11), 2326-2338 (2021). doi:10.1021/acschembio.1c00487
ACS chemical biology, 16(11). AMER CHEMICAL SOC
ACS chemical biology, 16(11). AMER CHEMICAL SOC
Leucine-Rich Repeat Kinase 2 (LRRK2) is a large, multidomain protein with dual kinase and GTPase function that is commonly mutated in both familial and idiopathic Parkinson's Disease (PD). While dimerization of LRRK2 is commonly detected in PD models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37fc033b725a6992a27c05c3fcd9f95
https://doi.org/10.1021/acschembio.1c00487
https://doi.org/10.1021/acschembio.1c00487
Autor:
Giambattista Guaitoli, Ranjan Kumar Singh, Laura Van Rillaer, Els Pardon, Christian Johannes Gloeckner, Eliza Störmer, Ahmed Soliman, Deep Chatterjee, Thomas Dal Maso, Stefan Knapp, Arjan Kortholt, Jan Steyaert, Felix von Zweydorf, Eileen J. Kennedy, Sven H. Schmidt, Friedrich W. Herberg, Wim Versées
Mutations in the gene coding for Leucine-Rich Repeat Kinase 2 (LRRK2) are a leading cause of the inherited form of Parkinson’s disease (PD), while LRRK2 overactivation is also associated with the more common idiopathic form of PD. LRRK2 is a large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39d780491f3d0d4ed084ae130620a85
https://doi.org/10.1101/2021.08.30.458082
https://doi.org/10.1101/2021.08.30.458082
Autor:
Angelos Skodras, Anna Julia Koppelmann, Jillian Madine, Katleen Wild, Lisa M. Haesler, Felix von Zweydorf, Karoline Degenhardt, Rusheka Maxwell, Philipp J. Kahle, Domenico Del Turco, Ulrike Obermüller, Thomas Deller, Mathias Jucker, Christian Johannes Gloeckner, Jonas J. Neher, Hannah A. Davies, Jessica Wagner, Carola Rotermund
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed12e13ec20144b999c39ce255a565b3
https://doi.org/10.1002/alz.042861
https://doi.org/10.1002/alz.042861
Autor:
Jorge Garcia Morato, Manuela Neumann, Christian Johannes Gloeckner, Angelos Skodras, Friederike Hans, Simon J Elsaesser, Felix von Zweydorf, Emanuele Buratti, Regina Feederle, Philipp J. Kahle
Publikováno v:
Nature Communications 13(1), 1223 (2022). doi:10.1038/s41467-022-28822-7
Nat. Commun. 13:1223 (2022)
Nat. Commun. 13:1223 (2022)
The trans-activation response DNA-binding protein TDP-43 regulates RNA processing and forms neuropathological aggregates in patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Investigating TDP-43 post-translational mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b746aefc39a137a222ef1f6d3b5e41
https://doi.org/10.1101/2020.05.26.104356
https://doi.org/10.1101/2020.05.26.104356
Autor:
Carla Perego, Franco Onofri, Maria Perez Carrion, Christian Johannes Gloeckner, Zeila Casiraghi, Felix von Zweydorf, P. Marciani, Giovanni Piccoli, Francesca Pischedda, Antonella Marte, A. Marku
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific reports 10(1), 3799 (2020). doi:10.1038/s41598-020-60834-5
Scientific Reports
Scientific reports 10(1), 3799 (2020). doi:10.1038/s41598-020-60834-5
Scientific Reports
The LRRK2 protein consists of multiple functional domains, including protein-binding domains at its N and C-terminus. Mutations in the Leucine-rich repeat kinase 2 gene (LRRK2) have been linked to familial and sporadic Parkinson’s disease (PD). We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0326f2d87d08fa1a41f79c1efee337d
https://doi.org/10.1038/s41598-020-60834-5
https://doi.org/10.1038/s41598-020-60834-5