Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Felix Wittig"'
Autor:
Thomas Freitag, Philipp Kaps, Justus Ramtke, Sarah Bertels, Emily Zunke, Björn Schneider, Anne-Sophie Becker, Dirk Koczan, Daniel Dubinski, Thomas M. Freiman, Felix Wittig, Burkhard Hinz, Mike-Andrew Westhoff, Hannah Strobel, Franziska Meiners, Daniel Wolter, Nadja Engel, Sascha Troschke-Meurer, Wendy Bergmann-Ewert, Susanne Staehlke, Annabell Wolff, Florian Gessler, Christian Junghanss, Claudia Maletzki
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-17 (2024)
Abstract Here, we show that combined use of the EZH2 inhibitor GSK126 and the CDK4/6 inhibitor abemaciclib synergistically enhances antitumoral effects in preclinical GBM models. Dual blockade led to HIF1α upregulation and CalR translocation, accomp
Externí odkaz:
https://doaj.org/article/48c31a82a0d54c5ea79c6f99d70e3d61
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 810 (2024)
β-Caryophyllene (BCP), a bicyclic sesquiterpene that is a component of the essential oils of various spice and food plants, has been described as a selective CB2 cannabinoid receptor agonist. In the present study, the effect of BCP on angiogenesis w
Externí odkaz:
https://doaj.org/article/ecfc1a6a561b4f8e8bb99e355a12fd3d
Autor:
Franziska Wendt, Felix Wittig, Anne Rupprecht, Robert Ramer, Peter Langer, Steffen Emmert, Marcus Frank, Burkhard Hinz
Publikováno v:
Cells, Vol 12, Iss 19, p 2409 (2023)
Skin cancer is the most common malignant disease worldwide and, therefore, also poses a challenge from a pharmacotherapeutic perspective. Derivatives of indirubin are an interesting option in this context. In the present study, the effects of 3-[3′
Externí odkaz:
https://doaj.org/article/e4d653d7f8ce482784066c1f5d33ff3b
Publikováno v:
Cells, Vol 12, Iss 19, p 2332 (2023)
JZL184, an inhibitor of monoacylglycerol lipase (MAGL) and thus of the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG), mediates various anticancer effects in preclinical studies. However, studies on the effect of this or other MAGL
Externí odkaz:
https://doaj.org/article/b7a6ef19c55d46c69e4510815a9a89f4
Publikováno v:
Cells, Vol 12, Iss 13, p 1757 (2023)
Despite the well-described anticarcinogenic effects of endocannabinoids, the influence of the endocannabinoid system on tumor angiogenesis is still debated. In the present study, conditioned medium (CM) from A549 and H358 lung cancer cells treated wi
Externí odkaz:
https://doaj.org/article/8a09d7985957491191bbd21a05b4f6e1
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6606 (2021)
Tissue factor (TF) plays an important role in the progression and angiogenesis of tumor cells. The present study investigated the mechanism of interleukin-1β (IL-1β)-induced TF expression in A549 lung cancer cells. Based on mRNA and protein analyse
Externí odkaz:
https://doaj.org/article/102db5573c4343a5af994ef027b3901e
Publikováno v:
Cells; Volume 12; Issue 13; Pages: 1757
Despite the well-described anticarcinogenic effects of endocannabinoids, the influence of the endocannabinoid system on tumor angiogenesis is still debated. In the present study, conditioned medium (CM) from A549 and H358 lung cancer cells treated wi
A targeted modulation of the endocannabinoid system is currently discussed as a promising strategy for cancer treatment. An important enzyme for the endocannabinoid metabolism is the monoacylglycerol lipase (MAGL), which catalyzes the degradation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0460831c9ecbd034026a49c1c7d00b6
https://doi.org/10.1158/1535-7163.c.6543205
https://doi.org/10.1158/1535-7163.c.6543205
Supplementary figures S1 - S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5002f657010abcb573d5230f21e037f8
https://doi.org/10.1158/1535-7163.22521865
https://doi.org/10.1158/1535-7163.22521865
Autor:
Kathrin Jäger, Juliane Mensch, Maria Elisabeth Grimmig, Bruno Neuner, Kerstin Gorzelniak, Seval Türkmen, Ilja Demuth, Alexander Hartmann, Christiane Hartmann, Felix Wittig, Anje Sporbert, Andreas Hermann, Georg Fuellen, Steffen Möller, Michael Walter
Publikováno v:
Science Advances
Science advances 8(33), eabk2814 (2022). doi:10.1126/sciadv.abk2814
Science advances 8(33), eabk2814 (2022). doi:10.1126/sciadv.abk2814
Telomeres are repetitive nucleotide sequences at the ends of each chromosome. It has been hypothesized that telomere attrition evolved as a tumor suppressor mechanism in large long-lived species. Long telomeres can silence genes millions of bases awa