Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction

Autor: Dieter Willbold, Lothar Gremer, Doreen M. Floss, Yvonne Arlt, Jens M. Moll, Joachim Grötzinger, Meryem Ouzin, Jürgen Scheller, Jacqueline Georgy, Hendrik T. Weitz, Felix Thives-Kurenbach

Publikováno v: The journal of biological chemistry 297(5), 101295-(2021). doi:10.1016/j.jbc.2021.101295
The Journal of Biological Chemistry

Interleukin (IL)-12 and IL-23 are composite cytokines consisting of p35/p40 and p19/p40, respectively, which signal via the common IL-12 receptor β1 (IL-12Rβ1) and the cytokine-specific receptors IL-12Rβ2 and IL-23R. Previous data showed that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7976beda10ed63407507c2f24981920
https://doi.org/10.1016/j.jbc.2021.101295