Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Felix Sommer"'
Autor:
Saskia Weber-Stiehl, Jan Taubenheim, Lea Järke, Christoph Röcken, Stefan Schreiber, Konrad Aden, Christoph Kaleta, Philip Rosenstiel, Felix Sommer
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Inflammation is characterized by a metabolic switch promoting glycolysis and lactate production. Hexokinases (HK) catalyze the first reaction of glycolysis and inhibition of epithelial HK2 protected from colitis in mice. HK2 expre
Externí odkaz:
https://doaj.org/article/4775c804c5424dc280a2419e833ba653
Autor:
Antonella Fazio, Dora Bordoni, Jan W. P. Kuiper, Saskia Weber-Stiehl, Stephanie T. Stengel, Philipp Arnold, David Ellinghaus, Go Ito, Florian Tran, Berith Messner, Anna Henning, Joana P. Bernardes, Robert Häsler, Anne Luzius, Simon Imm, Finn Hinrichsen, Andre Franke, Samuel Huber, Susanna Nikolaus, Konrad Aden, Stefan Schreiber, Felix Sommer, Gioacchino Natoli, Neha Mishra, Philip Rosenstiel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
DNA methyltransferase 3 A (DNMT3A) is involved in DNA methylation, and genetic variants in the DNMT3 locus have been associated with inflammatory bowel disease. Here the authors report that DNMT3A controls intestinal epithelial barrier function and r
Externí odkaz:
https://doaj.org/article/ddcd39941f044c5d889d3ab0cea581ef
Autor:
Juan Camilo Castrillón-Betancur, Víctor Alonso López-Agudelo, Nina Sommer, Sven Cleeves, Joana Pimenta Bernardes, Saskia Weber-Stiehl, Philip Rosenstiel, Felix Sommer
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1889 (2023)
Reactive oxygen species (ROS) are highly reactive molecules formed from diatomic oxygen. They act as cellular signals, exert antibiotic activity towards invading microorganisms, but can also damage host cells. Dual oxidase 2 (DUOX2) is the main ROS-p
Externí odkaz:
https://doaj.org/article/65adb601ceef40f79fd950d301d7502b
Autor:
Adorján Varga, Lilla Makszin, Anita Bufa, Dávid Sipos, Péter Kása, Szilárd Pál, Philip Rosenstiel, Felix Sommer, Béla Kocsis, Zoltán Péterfi
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Background and aimsFaecal microbiota transfer (FMT) has managed to earn its place in the Clostridioides difficile infection (CDI) guidelines by having comparable efficacy and recurrence rate of fidaxomicin. After more than 100 successful FMT administ
Externí odkaz:
https://doaj.org/article/8e1f6287568549c58081701c17f70685
Autor:
Lucas Moitinho-Silva, Michelle Wegener, Sandra May, Florian Schrinner, Awais Akhtar, Teide J. Boysen, Eva Schaeffer, Clint Hansen, Timo Schmidt, Malte C. Rühlemann, Matthias Hübenthal, Philipp Rausch, Mustafa T. Kondakci, Walter Maetzler, Stephan Weidinger, Matthias Laudes, Philip Süß, Dominik Schulte, Ralf Junker, Felix Sommer, Burkhard Weisser, Corinna Bang, Andre Franke
Publikováno v:
BMC Microbiology, Vol 21, Iss 1, Pp 1-14 (2021)
Abstract Background Human well-being has been linked to the composition and functional capacity of the intestinal microbiota. As regular exercise is known to improve human health, it is not surprising that exercise was previously described to positiv
Externí odkaz:
https://doaj.org/article/cffe0f6954c64a5c958c470c5d8478b4
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Energy and anabolic metabolism are essential for normal cellular homeostasis but also play an important role in regulating immune responses and cancer development as active immune and cancer cells show an altered metabolic profile. Mitochondria take
Externí odkaz:
https://doaj.org/article/57422433913b49ecab2304f0c865f3cd
Autor:
Dovydas Širvinskas, Omid Omrani, Jing Lu, Mahdi Rasa, Anna Krepelova, Lisa Adam, Sandra Kaeppel, Felix Sommer, Francesco Neri
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104202- (2022)
Summary: We performed massive single-cell sequencing in the aging mouse colonic epithelium and immune cells. We identified novel compartment-specific markers as well as dramatic aging-associated changes in cell composition and signaling pathways, inc
Externí odkaz:
https://doaj.org/article/af34670d0c61441ba873442f6c7f3199
Autor:
Lisa Mayr, Felix Grabherr, Julian Schwärzler, Isabelle Reitmeier, Felix Sommer, Thomas Gehmacher, Lukas Niederreiter, Gui-Wei He, Barbara Ruder, Kai T. R. Kunz, Piotr Tymoszuk, Richard Hilbe, David Haschka, Clemens Feistritzer, Romana R. Gerner, Barbara Enrich, Nicole Przysiecki, Markus Seifert, Markus A. Keller, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Ivan Tancevski, Heinz Zoller, Alexander R. Moschen, Günter Weiss, Christoph Becker, Philip Rosenstiel, Arthur Kaser, Herbert Tilg, Timon E. Adolph
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Dietary lipids are linked to the development of inflammatory bowel diseases through unclear mechanisms. Here, the authors report that dietary polyunsaturated fatty acids trigger intestinal inflammation resembling aspects of Crohn’s disease, which i
Externí odkaz:
https://doaj.org/article/fc87842ee61c451c8bde60fdd9105dee
Autor:
Jacqueline Moltzau Anderson, Simone Lipinski, Felix Sommer, Wei-Hung Pan, Olivier Boulard, Ateequr Rehman, Maren Falk-Paulsen, Stephanie T. Stengel, Konrad Aden, Robert Häsler, Richa Bharti, Sven Künzel, John F. Baines, Mathias Chamaillard, Philip Rosenstiel
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 365-389 (2020)
Background & Aims: Loss-of-function variants in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) impair the recognition of the bacterial cell wall component muramyl-dipeptide and are associated with an increased risk for developi
Externí odkaz:
https://doaj.org/article/e95bfd75ec354ac7851ece1df85a26f4
Autor:
Henning Formes, Joana P. Bernardes, Amrit Mann, Franziska Bayer, Giulia Pontarollo, Klytaimnistra Kiouptsi, Katrin Schäfer, Sebastian Attig, Teodora Nikolova, Thomas G. Hofmann, Jörn M. Schattenberg, Hristo Todorov, Susanne Gerber, Philip Rosenstiel, Tobias Bopp, Felix Sommer, Christoph Reinhardt
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103092- (2021)
Summary: The gut microbiota affects remote organ functions but its impact on organotypic endothelial cell (EC) transcriptomes remains unexplored. The liver endothelium encounters microbiota-derived signals and metabolites via the portal circulation.
Externí odkaz:
https://doaj.org/article/ee0261277c8044a4afde1def618b2469