Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Felix Scheuplein"'
Autor:
Felix Scheuplein, Florian Renner, John E. Campbell, Robert Campbell, Chris De Savi, Jan Eckmann, Holger Fischer, Jie Ge, Luke Green, Peter Jakob, Joseph L. Kim, Caitlin Kinkema, Katie McGinn, Ricardo Medina, Annemarie Müller, Nisha Perez, Emanuele Perola, Yoav Timsit, Tary Traore, Ulrike Hopfer, Stefka Tyanova, Manuel Tzouros, Ruduan Wang, Richard Woessner, Marion Dorsch, James R. Bischoff
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe serine/threonine kinase 17B (STK17B) is involved in setting the threshold for T cell activation and its absence sensitizes T cells to suboptimal stimuli. Consequently, STK17B represents an attractive potential target for cancer immuno
Externí odkaz:
https://doaj.org/article/301b248df8e548fc8ca6b2a6315e5115
Autor:
Felix Scheuplein, Deanna J Lamont, Matthew E Poynter, Jonathan E Boyson, David Serreze, Lennart K A Lundblad, Robert Mashal, Robert Schaub
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140729 (2015)
Invariant Natural Killer T (iNKT) cells are a T cell subset expressing an invariant T Cell Receptor (TCR) that recognizes glycolipid antigens rather than peptides. The cells have both innate-like rapid cytokine release, and adaptive-like thymic posit
Externí odkaz:
https://doaj.org/article/6980faa195b94b189f29fc0fda87c8e0
Autor:
Felix Scheuplein, Abraham Thariath, Susan Macdonald, Alemseged Truneh, Robert Mashal, Robert Schaub
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e76692 (2013)
Invariant Natural Killer T (iNKT) cells are a subset of T cells recognizing glycolipid antigens presented by CD1d. Human iNKT cells express a conserved T cell receptor (TCR)-α chain (Vα24-Jα18) paired with a specific beta chain, Vβ11. The cells a
Externí odkaz:
https://doaj.org/article/a2d03d30b20c43c095dc410e658f34db
Autor:
Rich Woessner, Alexandra Borodovsky, Kris Sachsenmeier, Felix Scheuplein, Robert W. Wilkinson, Chaoyang Ye, Simon Dovedi
Publikováno v:
Animal Models for the Development of Cancer Immunotherapy. :11-62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a74e9eaa708e24ebe7d30b3bb94662e
https://doi.org/10.1002/9781119535331.ch1
https://doi.org/10.1002/9781119535331.ch1
Autor:
Tina Zimmermann, Steven Bench, Andrea Romagnani, Klaus P. Hoeflich, Carsten Wolter, Michael Sheets, Kerrie Faia, Kerry-Ann Bright, Timothy LaBranche, Marion Dorsch, Alberto Toso, Gordon Heidkamp, James R. Bischoff, Alison Ribeiro, Joshua Close, Marina Bacac, Felix Scheuplein, Nisha Perez, Caitlin Utt, Emanuele Perola, Jan Eckmann, Kristina Fetalvero, Stefan Gross, Qiongfang Cao, Debora Paduraru, Grace O. Silva, Chaoyang Ye, Marly I. Roche, Luke Green, Erin O’Hearn, Tary Traore, Weifan Weng, Jason D. Brubaker, Joseph Kim, Michael Burke, Sylvia Herter, Chandra Miduturu, Erik Gerson, Tim Guzi, Rich Woessner
Publikováno v:
Cancer Research. 81:1717-1717
Hematopoietic progenitor kinase 1 (HPK1, MAP4K1) is a serine/threonine kinase that has been demonstrated to have suppressive effects across a range of immune cells, including T cells and dendritic cells. Loss of MAP4K1 kinase activity is sufficient t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eb54e4cfffcf5824710a2a61ff8ed1c
https://doi.org/10.1158/1538-7445.am2021-1717
https://doi.org/10.1158/1538-7445.am2021-1717
Autor:
Jonathan E. Boyson, Jennifer L. Ather, Oliver Dienz, Nirav Daphtary, Nazey Gulec, Lennart K. A. Lundblad, Minara Aliyeva, Felix Scheuplein, Victoria L. DeVault, Robert Schaub, Matthew E. Poynter
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 45:80-89
iNKT cells and mast cells have both been implicated in the syndrome of allergic asthma through their activation-induced release of Th2 type cytokines and secretion of histamine and other mediators, respectively, which can promote airways hyperrespons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85031421aa2b86ad84f5004f1fb80b79
https://doi.org/10.1016/j.pupt.2017.05.003
https://doi.org/10.1016/j.pupt.2017.05.003
Autor:
Devika Bahal, Nishant P. Patel, Robert Schaub, Felix Scheuplein, Tanwir Hashem, Rupali Das, Kim E. Nichols, Peng Guan
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4317, p 4317 (2020)
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4317, p 4317 (2020)
Invariant natural killer T cells (iNKTs) directly kill tumor cells and trans-activate the anti-tumor functions of dendritic cells (DC), natural killer (NK) cells, and T and B cells. As such, iNKTs serve as a powerful tool for use in cell-based cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5633ed00f2586ace232af7515fa87b
https://doi.org/10.3390/ijms21124317
https://doi.org/10.3390/ijms21124317
Autor:
Peter Bannas, Friedrich Koch-Nolte, Friedrich Haag, Irm Hermans-Borgmeyer, Lennart Well, Felix Scheuplein
Publikováno v:
Molecular Immunology. 48:1762-1770
T cells constitutively express low amounts of a toxin-related ADP-ribosylating ecto-enzyme, ART2.2. In inflammatory settings, cells release NAD, the substrate for ART2.2. The ART2.2 catalyzed ADP-ribosylation of cell surface proteins induces cell dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aaf6ea7b71ee9b17fae7f0e40341132
https://doi.org/10.1016/j.molimm.2011.04.015
https://doi.org/10.1016/j.molimm.2011.04.015
Autor:
Peter C. Reifsnyder, David V. Serreze, John P. Driver, Amanda A. Hewes, Yi-Guang Chen, Felix Scheuplein, Edward H. Leiter
Publikováno v:
The Journal of Immunology. 186:4278-4284
Although P2rx7 has been proposed as a type 1 diabetes (T1D) susceptibility gene in NOD mice, its potential pathogenic role has not been directly determined. To test this possibility, we generated a new NOD stock deficient in P2X7 receptors. T1D devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f72c63c3aea644427a7d85460d29bd76
https://doi.org/10.4049/jimmunol.1003733
https://doi.org/10.4049/jimmunol.1003733
Autor:
Friedrich Koch-Nolte, Friedrich Haag, Vanina Alzogaray, Ana Cauerhff, Nicole Schwarz, Jan Reyelt, Britta Schößow, Felix Scheuplein, Stefan Rothenburg, Fernando Alberto Goldbaum
Publikováno v:
The FASEB Journal. 21:3490-3498
The purpose of our study was to develop a tool for blocking the function of a specific leukocyte ecto-enzyme in vivo. ART2.2 is a toxin-related ecto-enzyme that transfers the ADP-ribose moiety from NAD onto other cell surface proteins. ART2.2 induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb910bb8cbb48a66f63f9763bc20a977
https://doi.org/10.1096/fj.07-8661com
https://doi.org/10.1096/fj.07-8661com