Testing mixing rules for structural and dynamical quantities in multi-component crowded protein solutions

Autor: Alessandro Gulotta, Saskia Bucciarelli, Felix Roosen-Runge, Olaf Holderer, Peter Schurtenberger, Anna Stradner

Publikováno v: APL Bioengineering, Vol 8, Iss 2, Pp 026116-026116-15 (2024)

Crowding effects significantly influence the phase behavior and the structural and dynamic properties of the concentrated protein mixtures present in the cytoplasm of cells or in the blood serum. This poses enormous difficulties for our theoretical u

Externí odkaz: https://doaj.org/article/561b535a1a974564a013a17c2368f114

Dynamics of post-occlusion water diffusion in stratum corneum

Autor: Ivan Argatov, Felix Roosen-Runge, Vitaly Kocherbitov

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract Diffusion of water through membranes presents a considerable challenge, as the diffusivity often depends on the local concentration of water. One particular example with strong biological relevance is the stratum corneum (SC) as the primary

Externí odkaz: https://doaj.org/article/afd8b2a25f6d4a50ab1e89692f82e5d5

Soft matter roadmap

Autor: Jean-Louis Barrat, Emanuela Del Gado, Stefan U Egelhaaf, Xiaoming Mao, Marjolein Dijkstra, David J Pine, Sanat K Kumar, Kyle Bishop, Oleg Gang, Allie Obermeyer, Christine M Papadakis, Constantinos Tsitsilianis, Ivan I Smalyukh, Aurelie Hourlier-Fargette, Sebastien Andrieux, Wiebke Drenckhan, Norman Wagner, Ryan P Murphy, Eric R Weeks, Roberto Cerbino, Yilong Han, Luca Cipelletti, Laurence Ramos, Wilson C K Poon, James A Richards, Itai Cohen, Eric M Furst, Alshakim Nelson, Stephen L Craig, Rajesh Ganapathy, Ajay Kumar Sood, Francesco Sciortino, Muhittin Mungan, Srikanth Sastry, Colin Scheibner, Michel Fruchart, Vincenzo Vitelli, S A Ridout, M Stern, I Tah, G Zhang, Andrea J Liu, Chinedum O Osuji, Yuan Xu, Heather M Shewan, Jason R Stokes, Matthias Merkel, Pierre Ronceray, Jean-François Rupprecht, Olga Matsarskaia, Frank Schreiber, Felix Roosen-Runge, Marie-Eve Aubin-Tam, Gijsje H Koenderink, Rosa M Espinosa-Marzal, Joaquin Yus, Jiheon Kwon

Publikováno v: JPhys Materials, Vol 7, Iss 1, p 012501 (2023)

Soft materials are usually defined as materials made of mesoscopic entities, often self-organised, sensitive to thermal fluctuations and to weak perturbations. Archetypal examples are colloids, polymers, amphiphiles, liquid crystals, foams. The impor

Externí odkaz: https://doaj.org/article/e3b13890a08a4e0db04b1d218c881f8b

ApoE and ApoE Nascent-Like HDL Particles at Model Cellular Membranes: Effect of Protein Isoform and Membrane Composition

Autor: Sarah Waldie, Federica Sebastiani, Martine Moulin, Rita Del Giudice, Nicolò Paracini, Felix Roosen-Runge, Yuri Gerelli, Sylvain Prevost, John C. Voss, Tamim A. Darwish, Nageshwar Yepuri, Harald Pichler, Selma Maric, V. Trevor Forsyth, Michael Haertlein, Marité Cárdenas

Publikováno v: Frontiers in Chemistry, Vol 9 (2021)

Apolipoprotein E (ApoE), an important mediator of lipid transportation in plasma and the nervous system, plays a large role in diseases such as atherosclerosis and Alzheimer's. The major allele variants ApoE3 and ApoE4 differ only by one amino acid.

Externí odkaz: https://doaj.org/article/9633a3e54bf542e08dd5a894dd1ccae2

Molecular Flexibility of Antibodies Preserved Even in the Dense Phase after Macroscopic Phase Separation

Autor: Anita Girelli, Christian Lang, Orsolya Czakkel, Tilo Seydel, Christian Beck, Olga Matsarskaia, Frank Schreiber, Fajun Zhang, Famke Bäuerle, Felix Roosen-Runge, Ralph Maier, Baohu Wu

Publikováno v: Molecular Pharmaceutics
Molecular Pharmaceutics, American Chemical Society, 2021, ⟨10.1021/acs.molpharmaceut.1c00555⟩
Molecular pharmaceutics 18(11), 4162–4169 (2021). doi:10.1021/acs.molpharmaceut.1c00555

Antibody therapies are typically based on high-concentration formulations that need to be administered subcutaneously. These conditions induce several challenges, inter alia a viscosity suitable for injection, sufficient solution stability, and prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e5237ece26dd0f1adfd4269b79350e
https://doi.org/10.1021/acs.molpharmaceut.1c00555