The inflammasome pathway is activated by dengue virus non-structural protein 1 and is protective during dengue virus infection.

Autor: Marcus P Wong, Evan Y W Juan, Felix Pahmeier, Sai S Chelluri, Phoebe Wang, Bryan Castillo-Rojas, Sophie F Blanc, Scott B Biering, Russell E Vance, Eva Harris

Publikováno v: PLoS Pathogens, Vol 20, Iss 4, p e1012167 (2024)

Dengue virus (DENV) is a medically important flavivirus causing an estimated 50-100 million dengue cases annually, some of whom progress to severe disease. DENV non-structural protein 1 (NS1) is secreted from infected cells and has been implicated as

Externí odkaz: https://doaj.org/article/68d4af973a844bef8593e012140fc8f3

The Biogenesis of Dengue Virus Replication Organelles Requires the ATPase Activity of Valosin-Containing Protein

Autor: Clément Mazeaud, Anaïs Anton, Felix Pahmeier, Aïssatou Aïcha Sow, Berati Cerikan, Wesley Freppel, Mirko Cortese, Ralf Bartenschlager, Laurent Chatel-Chaix

Publikováno v: Viruses, Vol 13, Iss 10, p 2092 (2021)

The dengue virus (DENV) causes the most prevalent arthropod-borne viral disease worldwide. While its incidence is increasing in many countries, there is no approved antiviral therapy currently available. In infected cells, the DENV induces extensive

Externí odkaz: https://doaj.org/article/736fe441efee4e0aa71b79e9435e0022

SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

Autor: Scott B. Biering, Francielle Tramontini Gomes de Sousa, Laurentia V. Tjang, Felix Pahmeier, Richard Ruan, Sophie F. Blanc, Trishna S. Patel, Caroline M. Worthington, Dustin R. Glasner, Bryan Castillo-Rojas, Venice Servellita, Nicholas T.N. Lo, Marcus P. Wong, Colin M. Warnes, Daniel R. Sandoval, Thomas Mandel Clausen, Yale A. Santos, Victoria Ortega, Hector C. Aguilar, Jeffrey D. Esko, Charles Y. Chui, John E. Pak, P. Robert Beatty, Eva Harris

Publikováno v: bioRxiv

SummarySevere COVID-19 is associated with epithelial and endothelial barrier dysfunction within the lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory response is associated with barrier dysfunction, the trigge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3cfd9ad1cea394b4853d1fc195c944
https://pubmed.ncbi.nlm.nih.gov/36494335

A Versatile Reporter System To Monitor Virus-Infected Cells and Its Application to Dengue Virus and SARS-CoV-2

Autor: Vibhu Prasad, Alessia Ruggieri, Berati Cerikan, Ralf Bartenschlager, Christopher J. Neufeldt, Vibor Laketa, Felix Pahmeier, Mirko Cortese, Constantin Pape

Publikováno v: Journal of Virology
Journal of virology, vol 95, iss 4

Reporter systems are useful tools for fast and quantitative visualization of virus-infected cells within a host cell population. Here, we describe a reporter system that takes advantage of virus-encoded proteases expressed in infected cells to cleave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580a62912fcb408e222ef3e69b4ac032

Novel toscana virus reverse genetics system establishes NSS as an antagonist of type I interferon responses

Autor: Megan L. Stanifer, Paul J. Wichgers Schreur, Felix Pahmeier, Pierre-Yves Lozach, Zina M. Uckeley, Stefan Windhaber, Gleyder Roman Sosa, Psylvia Léger, Steeve Boulant, Félix A. Rey, Franziska Woelfl, Nadia Oreshkova, Jeroen Kortekaas, Jana Koch

Publikováno v: Viruses
Volume 12
Issue 4
Viruses, 12(4)
Viruses, MDPI, 2020, 12 (4), pp.400. ⟨10.3390/v12040400⟩
Viruses, vol 12, iss 4
Viruses, Vol 12, Iss 400, p 400 (2020)
Viruses 12 (2020) 4

The sand fly-borne Toscana virus (TOSV) is the major cause of human meningoencephalitis in the Mediterranean basin during the summer season. In this work, we have developed a T7 RNA polymerase-driven reverse genetics system to recover infectious part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033a953fc500d7992667a7cbaa54e3fb
https://doi.org/10.3390/v12040400