Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Felix Orben"'
Autor:
Carolin Schneider, Jorina Hilbert, Franziska Genevaux, Stefanie Höfer, Lukas Krauß, Felix Schicktanz, Constanza Tapia Contreras, Shaishavi Jansari, Aristeidis Papargyriou, Thorsten Richter, Abdallah M. Alfayomy, Chiara Falcomatà, Christian Schneeweis, Felix Orben, Ruppert Öllinger, Florian Wegwitz, Angela Boshnakovska, Peter Rehling, Denise Müller, Philipp Ströbel, Volker Ellenrieder, Lena Conradi, Elisabeth Hessmann, Michael Ghadimi, Marian Grade, Matthias Wirth, Katja Steiger, Roland Rad, Bernhard Kuster, Wolfgang Sippl, Maximilian Reichert, Dieter Saur, Günter Schneider
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract Cancer cells must develop strategies to adapt to the dynamically changing stresses caused by intrinsic or extrinsic processes, or therapeutic agents. Metabolic adaptability is crucial to mitigate such challenges. Considering metabolism as a
Externí odkaz:
https://doaj.org/article/74f891ee4bb3409e8f62d1958c65fda1
Autor:
Johannes Roman Wiessner, Felix Orben, Arlett Schäfer, Lisa Fricke, Günter Schneider, Maximilian Reichert, Alexander Herner, Ulrich Mayr, Veit Phillip, Matthias Treiber, Guido von Figura, Mohamed Abdelhafez, Roland M. Schmid, Christoph Schlag
Publikováno v:
Endoscopy International Open, Vol 12, Iss 03, Pp E361-E366 (2024)
Externí odkaz:
https://doaj.org/article/46a2046c06d74262b70c9e5db2236a92
Autor:
Christian Schneeweis, Zonera Hassan, Katja Ascherl, Matthias Wirth, Stella Koutsouli, Felix Orben, Lukas Krauß, Carolin Schneider, Rupert Öllinger, Oliver H. Krämer, Roland Rad, Maximilian Reichert, Maria S. Robles, Dieter Saur, Günter Schneider
Publikováno v:
Cancer Communications, Vol 42, Iss 4, Pp 360-364 (2022)
Externí odkaz:
https://doaj.org/article/e1fb4121e0174834a41aa53409ac05ce
Autor:
Katja Peschke, Hannah Jakubowsky, Arlett Schäfer, Carlo Maurer, Sebastian Lange, Felix Orben, Raquel Bernad, Felix N Harder, Matthias Eiber, Rupert Öllinger, Katja Steiger, Melissa Schlitter, Wilko Weichert, Ulrich Mayr, Veit Phillip, Christoph Schlag, Roland M Schmid, Rickmer F Braren, Bo Kong, Ihsan Ekin Demir, Helmut Friess, Roland Rad, Dieter Saur, Günter Schneider, Maximilian Reichert
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 4, Pp 1-11 (2022)
Abstract Despite the advance and success of precision oncology in gastrointestinal cancers, the frequency of molecular‐informed therapy decisions in pancreatic ductal adenocarcinoma (PDAC) is currently neglectable. We present a longitudinal precisi
Externí odkaz:
https://doaj.org/article/4db5c456fd664265a4d6c307ca8e323b
Autor:
Catherine M. Biggs, Anna Cordeiro-Santanach, Sergey V. Prykhozhij, Adam P. Deveau, Yi Lin, Kate L. Del Bel, Felix Orben, Robert J. Ragotte, Aabida Saferali, Sara Mostafavi, Louie Dinh, Darlene Dai, Katja G. Weinacht, Kerry Dobbs, Lisa Ott de Bruin, Mehul Sharma, Kevin Tsai, John J. Priatel, Richard A. Schreiber, Jacob Rozmus, Martin C.K. Hosking, Kevin E. Shopsowitz, Margaret L. McKinnon, Suzanne Vercauteren, Michael Seear, Luigi D. Notarangelo, Francis C. Lynn, Jason N. Berman, Stuart E. Turvey
Publikováno v:
JCI Insight, Vol 7, Iss 24 (2022)
Primary atopic disorders are a group of inborn errors of immunity that skew the immune system toward severe allergic disease. Defining the biology underlying these extreme monogenic phenotypes reveals shared mechanisms underlying common polygenic all
Externí odkaz:
https://doaj.org/article/661f805e9c8745a39ed98cf73418141e
Autor:
Felix Orben, Katharina Lankes, Christian Schneeweis, Zonera Hassan, Hannah Jakubowsky, Lukas Krauß, Fabio Boniolo, Carolin Schneider, Arlett Schäfer, Janine Murr, Christoph Schlag, Bo Kong, Rupert Öllinger, Chengdong Wang, Georg Beyer, Ujjwal M. Mahajan, Yonggan Xue, Julia Mayerle, Roland M. Schmid, Bernhard Kuster, Roland Rad, Christian J. Braun, Matthias Wirth, Maximilian Reichert, Dieter Saur, Günter Schneider
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Systemic therapies for pancreatic ductal adenocarcinoma (PDAC) remain unsatisfactory. Clinical prognosis is particularly poor for tumor subtypes with activating aberrations in the MYC pathway, creating an urgent need for novel therapeutic targets. To
Externí odkaz:
https://doaj.org/article/eb693ba667cc4d5dae97e9b398a9f104
Autor:
Josefina Doffo, Stefanos A. Bamopoulos, Hazal Köse, Felix Orben, Chuanbing Zang, Miriam Pons, Alexander T. den Dekker, Rutger W. W. Brouwer, Apoorva Baluapuri, Stefan Habringer, Maximillian Reichert, Anuradha Illendula, Oliver H. Krämer, Markus Schick, Elmar Wolf, Wilfred F. J. van IJcken, Irene Esposito, Ulrich Keller, Günter Schneider, Matthias Wirth
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 119(9):e2105691119. National Academy of Sciences
Evasion from drug-induced apoptosis is a crucial mechanism of cancer treatment resistance. The proapoptotic protein NOXA marks an aggressive pancreatic ductal adenocarcinoma (PDAC) subtype. To identify drugs that unleash the death-inducing potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61098a89708d34a146809b69f37acdc2
https://pubmed.ncbi.nlm.nih.gov/35197278
https://pubmed.ncbi.nlm.nih.gov/35197278
Autor:
Chuanbing Zang, Stefanos A. Bamopoulos, Alexander T. den Dekker, Oliver H. Krämer, Matthias Wirth, Markus Schick, Felix Orben, Miriam Pons, Maximillian Reichert, Ulrich Keller, Irene Esposito, Rutger W W Brouwer, Elmar Wolf, Stefan Habringer, Apoorva Baluapuri, Anuradha lllendula, Wilfred F. J. van IJcken, Günter Schneider, Josefina Doffo, Hazal Köse
Evasion from drug-induced apoptosis is a crucial mechanism of cancer treatment resistance. The pro-apoptotic protein NOXA marks an aggressive pancreatic ductal adenocarcinoma (PDAC) subtype. To identify drugs that unleash the death-inducing potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::053a7c7030fdad7119b028535f6b89d4
https://doi.org/10.1101/2021.10.21.465266
https://doi.org/10.1101/2021.10.21.465266
Autor:
G Schneider, Veit Phillip, Maximilian Reichert, Matthias Treiber, M Abdelhafez, Felix Orben, G von Figura, Johannes R. Wießner, Lisa Fricke, RM Schmid, Arlett Schäfer, Ulrich Mayr, Alexander Herner, Christoph Schlag
Publikováno v:
Viszeralmedizin 2021 Gemeinsame Jahrestagung Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS), Sektion Endoskopie der DGVS, Deutsche Gesellschaft für Allgemein und Viszeralchirurgie (DGAV).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61764933f403301232dc2a83a0d8db50
https://doi.org/10.1055/s-0041-1734090
https://doi.org/10.1055/s-0041-1734090
Autor:
Felix Orben, Svenja Lier, Bo Kong, Lukas Krauß, Carolin Schneider, Matthias Wirth, Christoph Schlag, Anna Kuisl, Dieter Saur, Stephanie Heinzlmeir, Arlette Schäfer, Herwig Pongratz, Bernhard Kuster, Stefan Dove, Maximilian Reichert, Rupert Öllinger, Siavosh Mahboobi, Christian Schneeweis, Günter Schneider, Roland Rad, Zonera Hassan, Florian Bassermann, Andreas Sellmer, Thomas Engleitner
Publikováno v:
Bioorganic chemistry. 119
Targeted protein degradation offers new opportunities to inactivate cancer drivers and has successfully entered the clinic. Ways to induce selective protein degradation include proteolysis targeting chimera (PROTAC) technology and immunomodulatory (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf937b92b6dd4caedec23fe064a5a50
https://pubmed.ncbi.nlm.nih.gov/34838332
https://pubmed.ncbi.nlm.nih.gov/34838332