Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Felix Oppel"'
Autor:
Felix Oppel, Sarah Gendreizig, Laura Martinez-Ruiz, Javier Florido, Alba López-Rodríguez, Harkiren Pabla, Lakshna Loganathan, Leonie Hose, Philipp Kühnel, Pascal Schmidt, Matthias Schürmann, Judith Martha Neumann, Flavian Viyof Ful, Lars Uwe Scholtz, Dina Ligum, Frank Brasch, Karsten Niehaus, Germaine Escames, Tobias Busche, Jörn Kalinowski, Peter Goon, Holger Sudhoff
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-12 (2024)
Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly malignant disease with high death rates that have remained substantially unaltered for decades. Therefore, new treatment approaches are urgently needed. Human papillomavirus-negative
Externí odkaz:
https://doaj.org/article/b48cb2b735ec41e28abe7fab3ebcca50
Autor:
Sarah Gendreizig, Laura Martínez-Ruiz, Alba López-Rodríguez, Harkiren Pabla, Leonie Hose, Frank Brasch, Tobias Busche, Germaine Escames, Holger Sudhoff, Lars Uwe Scholtz, Ingo Todt, Felix Oppel
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-8 (2024)
Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly malignant disease, and death rates have remained at approximately 50% for decades. New tumor-targeting strategies are desperately needed, and a previous report indicated the triggered
Externí odkaz:
https://doaj.org/article/22447c4453464edfa9a069631b0389c4
Autor:
Peter Goon, Odile Sauzet, Matthias Schuermann, Felix Oppel, SenYao Shao, Lars-Uwe Scholtz, Holger Sudhoff, Martin Goerner
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-7 (2023)
Abstract Recurrent Respiratory Papillomatosis(RRP) is a rare disease with severe morbidity. Treatment is surgical. Prevailing viewpoint is that prophylactic HPV vaccines do not have therapeutic benefit due to their modus operandi. Studies on HPV vacc
Externí odkaz:
https://doaj.org/article/05c793da4e45430dadc178f4ab0641f8
Autor:
Laura Martinez-Ruiz, Javier Florido, César Rodriguez-Santana, Alba López-Rodríguez, Ana Guerra-Librero, Beatriz I. Fernández-Gil, Patricia García-Tárraga, José Manuel Garcia-Verdugo, Felix Oppel, Holger Sudhoff, David Sánchez-Porras, Amadeo Ten-Steve, José Fernández-Martínez, Pilar González-García, Iryna Rusanova, Darío Acuña-Castroviejo, Víctor Carriel, Germaine Escames
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115518- (2023)
Head and neck squamous cell carcinoma present a high mortality rate. Melatonin has been shown to have oncostatic effects in different types of cancers. However, inconsistent results have been reported for in vivo applications. Consequently, an altern
Externí odkaz:
https://doaj.org/article/88cf62c5f1de4102ac70780b346f856d
Autor:
Senyao Shao, Lars Uwe Scholtz, Sarah Gendreizig, Laura Martínez-Ruiz, Javier Florido, Germaine Escames, Matthias Schürmann, Carsten Hain, Leonie Hose, Almut Mentz, Pascal Schmidt, Menghang Wang, Peter Goon, Michael Wehmeier, Frank Brasch, Jörn Kalinowski, Felix Oppel, Holger Sudhoff
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background New concepts for a more effective anti-cancer therapy are urgently needed. Experimental flaws represent a major counter player of this development and lead to inaccurate and unreproducible data as well as unsuccessful translation
Externí odkaz:
https://doaj.org/article/d813f55e586f4212b4b82026e6ca59a1
Autor:
Matthias Schürmann, Felix Oppel, Senyao Shao, Verena Volland-Thurn, Christian Kaltschmidt, Barbara Kaltschmidt, Lars-Uwe Scholtz, Holger Sudhoff
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-15 (2021)
Abstract Background Cholesteatoma disease is an expanding lesion in the middle ear. Hearing loss and facial paralysis alongside with other intracranial complications are found. No pharmaceutical treatment is available today and recurrence after surgi
Externí odkaz:
https://doaj.org/article/1d4a878031d64d08af9168e7eddfeb5a
Publikováno v:
Frontiers in Surgery, Vol 8 (2021)
Objective: Eustachian tube function is of central importance for the ventilation of the middle ear. A dysfunction can be associated with chronic otitis media, and cholesteatoma. Balloon Eustachian tube dilatation (BET) is a treatment option used to s
Externí odkaz:
https://doaj.org/article/cf3c80648a9645ec979cdf96ae68b2f6
Autor:
Felix Oppel, Dong H. Ki, Mark W. Zimmerman, Kenneth N. Ross, Ting Tao, Hui Shi, Shuning He, Jon C. Aster, A. Thomas Look
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 8 (2020)
Polycomb repressive complex 2 (PRC2) is an epigenetic regulator of gene expression that possesses histone methyltransferase activity. PRC2 trimethylates lysine 27 of histone H3 proteins (H3K27me3) as a chromatin modification associated with repressed
Externí odkaz:
https://doaj.org/article/9652420fb6814c8ab9af147d0275ee95
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Tumors may consist of billions of cells, which in malignant cases disseminate and form distant metastases. The large number of tumor cells formed by the high number of cell divisions during tumor progression creates a heterogeneous set of genetically
Externí odkaz:
https://doaj.org/article/8f7ce32b3c6844298b2f61f03b0b54c1
Autor:
Claudia R Ball, Felix Oppel, Karl Roland Ehrenberg, Taronish D Dubash, Sebastian M Dieter, Christopher M Hoffmann, Ulrich Abel, Friederike Herbst, Moritz Koch, Jens Werner, Frank Bergmann, Naveed Ishaque, Manfred Schmidt, Christof von Kalle, Claudia Scholl, Stefan Fröhling, Benedikt Brors, Wilko Weichert, Jürgen Weitz, Hanno Glimm
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 7, Pp 918-932 (2017)
Abstract Although tumor‐initiating cell (TIC) self‐renewal has been postulated to be essential in progression and metastasis formation of human pancreatic adenocarcinoma (PDAC), clonal dynamics of TICs within PDAC tumors are yet unknown. Here, we
Externí odkaz:
https://doaj.org/article/806e5c3796d448e3a3f8956eba08fa15