Výsledky vyhledávání - "Felix O. Okunlola"

Elucidating the Dynamics and Selective Mechanistic Mode of Inhibition of a Novel Poly ADP-Ribose Polymerase-1 Inhibitor

Autor: Opeyemi S. Soremekun, Fisayo A. Olotu, Mahmoud E. S. Soliman, Felix O. Okunlola

Publikováno v: Letters in Drug Design & Discovery. 19:379-386

Poly ADP-ribose polymerase-1 (PARP-1), due to its role in DNA damage and repair, has been identified as a crucial therapeutic target to attenuate cancer development and progression. More so, selective inhibition has remained a focal point in PARP-1 t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27c635d4439a0e4af6d4293df7260eff
https://doi.org/10.2174/1570180818666210401131531

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Could the spanning of NAM-AD subsites by poly (ADP ribose) polymerase inhibitors potentiate their selective inhibitory activity in breast cancer treatment? Insight from biophysical computations

Autor: Oluwole B. Akawa, Mahmoud E. S. Soliman, Felix O. Okunlola

Publikováno v: Molecular Simulation. 48:131-139

Poly (ADP-ribose) polymerase (PARP) inhibition by pharmacological agents has been a useful cancer treatment in recent times. PARP inhibitors represent a category of anticancer drugs that function b...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24388c094eb587541ebb06a87a39b362
https://doi.org/10.1080/08927022.2021.1994562

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Unravelling the Mechanistic Role of Quinazolinone Pharmacophore in the Inhibitory Activity of Bis-quinazolinone Derivative on Tankyrase-1 in the Treatment of Colorectal Cancer (CRC) and Non-small Cell Lung Cancer (NSCLC): A Computational Approach

Autor: Oluwole B. Akawa, Felix O. Okunlola, Mahmoud E. S. Soliman, Temitayo I. Subair, Kehinde F. Omolabi

Publikováno v: Cell Biochemistry and Biophysics. 80:1-10

In recent years, tankyrase inhibition has gained a great focus as an anti-cancer strategy due to their modulatory effect on WNT/β-catenin pathway implicated in many malignancies, including colorectal cancer (CRC) and non-small cell lung cancer (NSCL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54bfced386f7cfc9ac7dd16b5a4a1b7b
https://doi.org/10.1007/s12013-021-01027-3

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East to West not North-West: Structure-Based Mechanistic Resolution of 8-Hydroxyl Replacement and Resulting Effects on the Activities of Imidazole-Based Heme Oxygenase-1 Inhibitors

Autor: Felix O. Okunlola, Opeyemi S. Soremekun, Mahmoud E. S. Soliman, Fisayo A. Olotu

Publikováno v: The Protein Journal. 40:166-174

Upregulation of Heme Oxygenase-1 (HO-1) has been widely implicated in cancer growth and chemoresistance. This explains the numerous drug discovery efforts aimed at mitigating its pro-carcinogenic roles till date. In a recent study, two selective azol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::030df39f257fc9985eca8eb25afa5f9d
https://doi.org/10.1007/s10930-021-09969-6

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Talazoparib Dual-targeting on Poly (ADP-ribose) Polymerase-1 and -16 Enzymes Offers a Promising Therapeutic Strategy in Small Cell Lung Cancer Therapy: Insight from Biophysical Computations

Autor: Chwayita, Mgoboza, Felix O, Okunlola, Oluwole B, Akawa, Aimen, Aljoundi, Mahmoud E S, Soliman

Publikováno v: Cell biochemistry and biophysics. 80(3)

In recent times, inhibition of poly (ADP-ribose) polymerase (PARP) enzymes by pharmacological drugs has attracted much attention as an anticancer therapy. As reported, PARP-16 has been discovered as a novel anticancer target for small cell lung cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe7234dc72356937365f1e6785b33a7f
https://pubmed.ncbi.nlm.nih.gov/35588345

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Simulation Models for Prediction of Bioavailability of Medicinal Drugs-the Interface Between Experiment and Computation

Autor: Mahmoud E, Soliman, Adeniyi T, Adewumi, Oluwole B, Akawa, Temitayo I, Subair, Felix O, Okunlola, Oluwayimika E, Akinsuku, Shahzeb, Khan

Publikováno v: AAPS PharmSciTech. 23(3)

The oral drug bioavailability (BA) problems have remained inevitable over the years, impairing drug efficacy and indirectly leading to eventual human morbidity and mortality. However, some conventional lab-based methods improve drug absorption leadin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::283eec4347dae00ed2582072319eb450
https://pubmed.ncbi.nlm.nih.gov/35292867

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Unveiling the mechanistic roles of chlorine substituted phthalazinone-based compounds containing chlorophenyl moiety towards the differential inhibition of poly (ADP-ribose) polymerase-1 in the treatment of lung cancer

Autor: Felix O. Okunlola, Mahmoud E. S. Soliman, Fisayo A. Olotu

Publikováno v: Journal of biomolecular structuredynamics. 40(21)

PARP-1 has become an attractive target in cancer treatment owing to its significant role in breast and ovarian cancers. The design of highly selective and effective poly (ADP ribose) polymerase-1 inhibitors has significant therapeutic advantages and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45dcfa0c9efedf2d06954fedc673f0a4
https://pubmed.ncbi.nlm.nih.gov/34463214

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Autor: Felix O, Okunlola, Oluwole B, Akawa, Temitayo I, Subair, Kehinde F, Omolabi, Mahmoud E S, Soliman

Publikováno v: Cell biochemistry and biophysics. 80(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::310fa768314c24abcf6b19288ee9963b
https://pubmed.ncbi.nlm.nih.gov/34453681

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