Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Felix M. Munkonge"'
Autor:
Stephen C. Hyde, Jie Zhu, David J. Porteous, Bernard Verdon, Brandon J. Wainwright, Felix M. Munkonge, Mario Chan, Makoto Inoue, Raymond Farley, J You, Duncan M. Geddes, Charanjit Singh, Barry E. Argent, Eric W.F.W. Alton, Michael A. Gray, A Wright, Akihiro Iida, Stefano Ferrari, Mamoru Hasegawa, Stephen N. Smith, H Ban, Peter K. Jeffery, Uta Griesenbach
The potential for gene therapy to be an effective treatment for cystic fibrosis has been hampered by the limited gene transfer efficiency of current vectors. We have shown that recombinant Sendai virus (SeV) is highly efficient in mediating gene tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a6fadb3fedf8fb3f43ca71f1c5cb8f
https://ora.ox.ac.uk/objects/uuid:a63c8b2a-5d9b-4e9c-9587-5c21a0f412a7
https://ora.ox.ac.uk/objects/uuid:a63c8b2a-5d9b-4e9c-9587-5c21a0f412a7
Autor:
Uta Griesenbach, Seng H. Cheng, Ronald K. Scheule, Eric W.F.W. Alton, Felix M. Munkonge, Katherine M. Wilson, R Farley, C Meng
Publikováno v:
The Journal of Gene Medicine. 14:491-500
Background The nuclear membrane of differentiated airway epithelial cells is a significant barrier for nonviral vectors. Trans-cyclohexane-1,2-diol (TCHD) is an amphipathic alcohol that has been shown to collapse nuclear pore cores and allow the upta
Publikováno v:
Molecular Therapy. 17(11):1897-1903
Although transfections are routinely used in the laboratory, the mechanism(s) by which exogenous DNA is transported into the nucleus is poorly understood. By improving our understanding of how vectors circumvent the numerous cellular barriers to gene
Autor:
Makoto Inoue, H Ban, Akihiro Iida, Eric W.F.W. Alton, Mario Chan, Mamoru Hasegawa, Felix M. Munkonge, Uta Griesenbach
Publikováno v:
Gene Therapy. 14:1688-1694
Sendai virus (SeV) vector has been shown to efficiently transduce airway epithelial cells. As a precursor to the potential use of this vector for cystic fibrosis (CF) gene therapy, the correct maturation of the SeV vector-derived CF transmembrane con
Autor:
Jie Zhu, Amanda Heinl-Green, Felix M. Munkonge, Peter W. Radke, Oliver M. Frass, Eric W.F.W. Alton, Duncan M. Geddes, Karen Vincent
Publikováno v:
European Heart Journal. 26:1327-1332
Therapeutic angiogenesis is a potential new treatment for patients unsuitable for conventional revascularization strategies. We investigated angiogenesis via a 'master switch gene' hypoxia inducible factor (HIF-1alpha).Ameroid occluders were placed a
Autor:
Charlotte Andersson, Aleksander Edelman, Ray Farley, Lena Hjelte, Godfried M. Roomans, Felix M. Munkonge, Gerry McLachlan, Anca Dragomir, M Stern, Eric W.F.W. Alton, Heather Davidson
Publikováno v:
Munkonge, F, Alton, E W F W, Andersson, C, Davidson, H, Dragomir, A, Edelman, A, Farley, R, Hjelte, L, McLachlan, G, Stern, M & Roomans, G M 2004, ' Measurement of halide efflux from cultured and primary airway epithelial cells using fluorescence indicators ', Journal of Cystic Fibrosis, vol. 3 Suppl 2, pp. 171-6 . https://doi.org/10.1016/j.jcf.2004.05.036
The use of the halide-sensitive fluorescent probes (6-methoxy-N-(−sulphopropyl)quinolinium (SPQ) and N-(ethoxycarbonylmethyl)-6-methoxyquinolinium bromide (MQAE)) to measure chloride transport in cells has now been established as an alternative to
Autor:
Duncan M. Geddes, C Masse, Y Berthiaume, C Robinson, Felix M. Munkonge, J Copeland, M Stern, K Ulrich, Ewfw Alton, Uta Griesenbach, S H Cheng
Publikováno v:
Gene Therapy. 7:960-966
Resolution of pulmonary oedema is mediated by active absorption of liquid across the alveolar epithelium. A key component of this process is the sodium-potassium ATPase (Na+K+-ATPase) enzyme located on the basolateral surface of epithelial cells and
Autor:
Stephen C. Hyde, David J. Porteous, Uta Griesenbach, Deborah R. Gill, Mario Chan, Stephanie G Sumner-Jones, Syahril Abdullah, Ian A. Pringle, Reto P. Bazzani, Lee A. Davies, Anne-Marie Green, Felix M. Munkonge, Anna E. Lawton, Anusha Varathalingam, Jane C. Davies, Graciela A Nunez-Alonso, Eric W.F.W. Alton, A. Christopher Boyd, Seng H. Cheng, Nelson S. Yew, Hongyu Li, David N. Sheppard
Publikováno v:
Nature Biotechnology. 26:549-551
Pulmonary delivery of plasmid DNA (pDNA)/cationic liposome complexes is associated with an acute unmethylated CG dinucleotide (CpG)-mediated inflammatory response and brief duration of transgene expression. We demonstrate that retention of even a sin
Autor:
M Stern, Felix M. Munkonge, Leaf Huang, Natasha J. Caplen, T. Pitt, Ann Dewar, Andrew Bush, Duncan M. Geddes, Eric W.F.W. Alton, Jane C. Davies, F. Sorgi
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 16:657-663
Much of the morbidity and mortality seen in cystic fibrosis (CF) is related to chronic infection of the respiratory tract with Pseudomonas aeruginosa. Some studies have attributed the strong relationship between CF and Pseudomonas colonization to the
Autor:
Amy Frost, Felix M. Munkonge, Leaf Huang, Eric W.F.W. AIton, M Stern, Charles Coutelle, Maria Vasilliou, Stephen L. Hart, Robert Williamson, Edward S. Mayall
Publikováno v:
Human Molecular Genetics. 4:1597-1602
Phase one clinical trials for gene therapy of cystic fibrosis are in progress using either liposomes or adenoviral vectors for CFTR gene transfer to epithelial cells in the airways. In addition to electrophysiological measurements, expression of vect