Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Felix M, Kluxen"'
Autor:
Arianna Bassan, Ronald Steigerwalt, Douglas Keller, Lisa Beilke, Paul M. Bradley, Frank Bringezu, William J. Brock, Leigh Ann Burns-Naas, Jon Chambers, Kevin Cross, Michael Dorato, Rosalie Elespuru, Douglas Fuhrer, Frances Hall, Jim Hartke, Gloria D. Jahnke, Felix M. Kluxen, Eric McDuffie, Friedemann Schmidt, Jean-Pierre Valentin, David Woolley, Doris Zane, Glenn J. Myatt
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
The ICH S1B carcinogenicity global testing guideline has been recently revised with a novel addendum that describes a comprehensive integrated Weight of Evidence (WoE) approach to determine the need for a 2-year rat carcinogenicity study. In the pres
Externí odkaz:
https://doaj.org/article/3419c3b90a414f7aafa8e7a2a11aedc0
Autor:
Felix M. Kluxen, Signe M. Jensen
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 21, Pp 1130-1150 (2022)
Statistical analyses are an essential part of regulatory toxicological evaluations. While projects would be ideally monitored by both toxicologists and statisticians, this is often not possible in practice. Hence, toxicologists should be trained in s
Externí odkaz:
https://doaj.org/article/660366e1cf9642c4ac013a8b62618136
Publikováno v:
Journal of Consumer Protection and Food Safety. 18:163-178
There are stringent EU regulatory requirements to assess pesticide exposure to bystanders and residents to direct spray drift. A “light clothing” adjustment factor (AF) of 0.82 is applied in the exposure assessment, based on simple assumptions fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87a99dbf2d91a3a58aa6abc6daa86319
https://doi.org/10.1007/s00003-023-01416-1
https://doi.org/10.1007/s00003-023-01416-1
Autor:
Namali Corea, Marco Corvaro, Felix M. Kluxen, Arthur Grivel, Neil Morgan, Christiane Wiemann, David Basketter
Publikováno v:
Regulatory Toxicology and Pharmacology. 141:105408
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8ddeeadc314bad1b3f21e6f0ce5e80a
https://doi.org/10.1016/j.yrtph.2023.105408
https://doi.org/10.1016/j.yrtph.2023.105408
Publikováno v:
Journal of Consumer Protection and Food Safety. 18:179-179
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::550f82022ec9ff8fb7a9df196f5812b2
https://doi.org/10.1007/s00003-023-01430-3
https://doi.org/10.1007/s00003-023-01430-3
Autor:
Edgars Felkers, Christian J. Kuster, Felix M. Kluxen, Nicola J. Hewitt, Neil Morgan, C. Wiemann
Publikováno v:
Annals of Work Exposures and Health. 65:397-405
Currently, the standard approach to estimate systemic exposure of workers after contact with dried pesticide residues on crops during re-entry activities relies on using the highest identified dermal absorption value for aqueous spray dilutions. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71902285cf60f43932f87cf41050ce03
https://doi.org/10.1093/annweh/wxaa139
https://doi.org/10.1093/annweh/wxaa139
Autor:
Felix M. Kluxen, Edgars Felkers, Steve McEuen, Philip Fisher, Christian Strupp, Christine Lorez, Jeanne Y. Domoradzki, Christiane Wiemann
Publikováno v:
Archives of toxicology. 96(9)
Dermal absorption values are used to translate external dermal exposure into potential systemic exposure for non-dietary risk assessment of pesticides. While the Environmental Protection Agency of the United States of America (US EPA) derives a commo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3e86225b490e8fd1f97752c74eed33
https://pubmed.ncbi.nlm.nih.gov/35704048
https://pubmed.ncbi.nlm.nih.gov/35704048
Autor:
Ludwig A. Hothorn, Felix M. Kluxen
Publikováno v:
Archives of Toxicology. 94:1135-1149
The goal of (eco-) toxicological testing is to experimentally establish a dose or concentration–response and to identify a threshold with a biologically relevant and probably non-random deviation from “normal”. Statistical tests aid this proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb0c434d07c4bd40bfc093637774d6ae
https://doi.org/10.1007/s00204-020-02690-w
https://doi.org/10.1007/s00204-020-02690-w
Autor:
Felix M, Kluxen, Styliani, Totti, Wilfred, Maas, Frank, Toner, Leanne, Page, Kathryn, Webbley, Rajendra, Nagane, Robert, Mingoia, Christine, Whitfield, John, Kendrick, Claire, Valentine, Jeanne Bernal, Dorange, Camille, Egron, Camille, Imart, Jeanne Y, Domoradzki, Philip, Fisher, Christine, Lorez, Steve, McEuen, Edgars, Felkers, Tao, Chen, Christiane, Wiemann
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 132
The dermal absorption potential of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c85a9344b6eed996daba05895c09aebb
https://pubmed.ncbi.nlm.nih.gov/35811177
https://pubmed.ncbi.nlm.nih.gov/35811177
Publikováno v:
Jensen, S M, Kluxen, F M & Ritz, C 2022, ' Benchmark dose modelling in regulatory ecotoxicology, a potential tool in pest management ', Pest Management Science, vol. 78, no. 5, pp. 1772-1779 . https://doi.org/10.1002/ps.6759
For several authorities, benchmark dose (BMD) methodology has become the recommended approach by which to derive reference values for risk assessment. However, in practice, the BMD approach is not standard use in risk assessment for pesticides where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40399135dea62bf40c7160cdba79ae67
https://curis.ku.dk/portal/da/publications/benchmark-dose-modelling-in-regulatory-ecotoxicology-a-potential-tool-in-pest-management(c119805c-fd02-473a-b5af-aabfe7c1b302).html
https://curis.ku.dk/portal/da/publications/benchmark-dose-modelling-in-regulatory-ecotoxicology-a-potential-tool-in-pest-management(c119805c-fd02-473a-b5af-aabfe7c1b302).html
