Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Felix Krueger"'
Autor:
Marc Jan Bonder, Stephen J. Clark, Felix Krueger, Siyuan Luo, João Agostinho de Sousa, Aida M. Hashtroud, Thomas M. Stubbs, Anne-Katrien Stark, Steffen Rulands, Oliver Stegle, Wolf Reik, Ferdinand von Meyenn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Ageing is the accumulation of changes and decline of function of organisms over time. The concept and biomarkers of biological age have been established, notably DNA methylation-based clocks. The emergence of single-cell DNA methylation prof
Externí odkaz:
https://doaj.org/article/ad7a8eed3efe49fdb4a325112b626eb9
Autor:
Olga Mielczarek, Carolyn H. Rogers, Yinxiu Zhan, Louise S. Matheson, Michael J.T. Stubbington, Stefan Schoenfelder, Daniel J. Bolland, Biola M. Javierre, Steven W. Wingett, Csilla Várnai, Anne Segonds-Pichon, Simon J. Conn, Felix Krueger, Simon Andrews, Peter Fraser, Luca Giorgetti, Anne E. Corcoran
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113074- (2023)
Summary: To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (VH), diversity (DH), and joining (JH)
Externí odkaz:
https://doaj.org/article/125cbc8ecfba40ce99ab9245a423021d
Autor:
Laura Saucedo-Cuevas, Elena Ivanova, Anamaria-Cristina Herta, Felix Krueger, Katy Billooye, Johan Smitz, Gavin Kelsey, Ellen Anckaert
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background In their attempt to fulfill the wish of having children, women who suffer from fertility issues often undergo assisted reproductive technologies such as ovarian stimulation, which has been associated with adverse health outcomes a
Externí odkaz:
https://doaj.org/article/4958daa73f6d477eb5f1446daf979c18
Autor:
Maria Arez, Melanie Eckersley-Maslin, Tajda Klobučar, João von Gilsa Lopes, Felix Krueger, Annalisa Mupo, Ana Cláudia Raposo, David Oxley, Samantha Mancino, Anne-Valerie Gendrel, Bruno Bernardes de Jesus, Simão Teixeira da Rocha
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) is associated with epigenetic alterations. Here the authors assess DNA methylation in detail in multiple female and male mouse iPSC lines generated with different protocols and fin
Externí odkaz:
https://doaj.org/article/fb75e50bfe994000b134b58a729bd94e
Autor:
Stephen J. Clark, Ricard Argelaguet, Tim Lohoff, Felix Krueger, Deborah Drage, Berthold Göttgens, John C. Marioni, Jennifer Nichols, Wolf Reik
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-20 (2022)
Abstract Background Perturbation of DNA methyltransferases (DNMTs) and of the active DNA demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases results in severe developmental defects and embryonic lethality. Dynamic con
Externí odkaz:
https://doaj.org/article/b2195c14571047cdb9fd7debc8032fd3
Autor:
Javier Rodríguez-Ubreva, Anna Arutyunyan, Marc Jan Bonder, Lucía Del Pino-Molina, Stephen J. Clark, Carlos de la Calle-Fabregat, Luz Garcia-Alonso, Louis-François Handfield, Laura Ciudad, Eduardo Andrés-León, Felix Krueger, Francesc Català-Moll, Virginia C. Rodríguez-Cortez, Krzysztof Polanski, Lira Mamanova, Stijn van Dongen, Vladimir Yu. Kiselev, María T. Martínez-Saavedra, Holger Heyn, Javier Martín, Klaus Warnatz, Eduardo López-Granados, Carlos Rodríguez-Gallego, Oliver Stegle, Gavin Kelsey, Roser Vento-Tormo, Esteban Ballestar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Common variable immunodeficiency (CVID) is the most prevalent primary immunodeficiency. Here the authors perform single-cell omics analyses in CVID-discordant monozygotic twins and show epigenetic and transcriptional alterations associated with activ
Externí odkaz:
https://doaj.org/article/756d963f7c144359bcee7edece23814e
Autor:
John A. Halsall, Simon Andrews, Felix Krueger, Charlotte E. Rutledge, Gabriella Ficz, Wolf Reik, Bryan M. Turner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Chromatin configuration influences gene expression in eukaryotes at multiple levels, from individual nucleosomes to chromatin domains several Mb long. Post-translational modifications (PTM) of core histones seem to be involved in chromatin s
Externí odkaz:
https://doaj.org/article/638296035c4644d5b4cc65f25c7d7cda
Autor:
Oliver Thompson, Ferdinand von Meyenn, Zoe Hewitt, John Alexander, Andrew Wood, Richard Weightman, Sian Gregory, Felix Krueger, Simon Andrews, Ivana Barbaric, Paul J. Gokhale, Harry D. Moore, Wolf Reik, Marta Milo, Serena Nik-Zainal, Kosuke Yusa, Peter W. Andrews
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mutations in human pluripotent stem cells (PSC) and whether any form during culture prior to use in a human clinical context are a concern. Here, the authors use hPSCs derived to cGMP standards and show they have low mutation rates after culture, not
Externí odkaz:
https://doaj.org/article/6f55e007701f4013b3a7b971436b8888
Autor:
Manusnan Suriyalaksh, Celia Raimondi, Abraham Mains, Anne Segonds-Pichon, Shahzabe Mukhtar, Sharlene Murdoch, Rebeca Aldunate, Felix Krueger, Roger Guimerà, Simon Andrews, Marta Sales-Pardo, Olivia Casanueva
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103663- (2022)
Summary: We design a “wisdom-of-the-crowds” GRN inference pipeline and couple it to complex network analysis to understand the organizational principles governing gene regulation in long-lived glp-1/Notch Caenorhabditis elegans. The GRN has three
Externí odkaz:
https://doaj.org/article/d7864594db424057aaddbda6be37f21a
Autor:
Courtney W. Hanna, Raquel Pérez-Palacios, Lenka Gahurova, Michael Schubert, Felix Krueger, Laura Biggins, Simon Andrews, Maria Colomé-Tatché, Deborah Bourc’his, Wendy Dean, Gavin Kelsey
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background Genomic imprinting is an epigenetic phenomenon that allows a subset of genes to be expressed mono-allelically based on the parent of origin and is typically regulated by differential DNA methylation inherited from gametes. Imprint
Externí odkaz:
https://doaj.org/article/1f13e69e51574ec4ae0c64c683c949cc