Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Felix Kopp"'
Autor:
Andrea Lopez, Denis E. Reyna, Nadege Gitego, Felix Kopp, Hua Zhou, Miguel A. Miranda-Roman, Lars Ulrik Nordstrøm, Swathi-Rao Narayanagari, Ping Chi, Eduardo Vilar, Aristotelis Tsirigos, Evripidis Gavathiotis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Deregulation of the BCL-2 family interactions ensures cancer resistance to apoptosis and is a major challenge to current treatments. Here the authors describe a novel therapeutic strategy to overcome two anti-apoptotic mechanisms for cancer therapy.
Externí odkaz:
https://doaj.org/article/5fa5a69a971e4641aa8580f63eda1948
Autor:
Zdeněk Dvořák, Felix Kopp, Cait M Costello, Jazmin S Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U Nordstroem, Chamini V Karunaratne, Harmit S Ranhotra, Kyu Shik Mun, Anjaparavanda P Naren, Iain A Murray, Gary H Perdew, Julius Brtko, Lucia Toporova, Arne Schön, Bret D Wallace, William G Walton, Matthew R Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L Flannigan, Simon A Hirota, Ryan Balfour Sartor, Sridhar Mani
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-19 (2020)
Abstract The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that esta
Externí odkaz:
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
Autor:
Konstantin Willer, Alexander A Fingerle, Lukas B Gromann, Fabio De Marco, Julia Herzen, Klaus Achterhold, Bernhard Gleich, Daniela Muenzel, Kai Scherer, Martin Renz, Bernhard Renger, Felix Kopp, Fabian Kriner, Florian Fischer, Christian Braun, Sigrid Auweter, Katharina Hellbach, Maximilian F Reiser, Tobias Schroeter, Juergen Mohr, Andre Yaroshenko, Hanns-Ingo Maack, Thomas Pralow, Hendrik van der Heijden, Roland Proksa, Thomas Koehler, Nataly Wieberneit, Karsten Rindt, Ernst J Rummeny, Franz Pfeiffer, Peter B Noël
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204565 (2018)
Disorders of the lungs such as chronic obstructive pulmonary disease (COPD) are a major cause of chronic morbidity and mortality and the third leading cause of death in the world. The absence of sensitive diagnostic tests for early disease stages of
Externí odkaz:
https://doaj.org/article/24a1975776f3430bb000b242b031f042
Autor:
Robert Nothhelfer, Felix Kopp
Publikováno v:
WiSt - Wirtschaftswissenschaftliches Studium. 48:60-66
Trotz theoretisch effizienter Märkte sind Übernahmeprämien von über 30 % eher die Norm als eine Ausnahme. Die erwerbenden Unternehmen haben oft Schwierigkeiten ihren Investoren zu erklären, warum diese Prämien gerechtfertigt sein könnten. Dies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d5371e5122591630408d9e17fbe9ca
https://doi.org/10.15358/0340-1650-2019-10-60
https://doi.org/10.15358/0340-1650-2019-10-60
Autor:
Andrea Lopez, Denis E. Reyna, Nadege Gitego, Felix Kopp, Hua Zhou, Miguel A. Miranda-Roman, Lars Ulrik Nordstrøm, Swathi-Rao Narayanagari, Ping Chi, Eduardo Vilar, Aristotelis Tsirigos, Evripidis Gavathiotis
Publikováno v:
Nature communications. 13(1)
Deregulation of the BCL-2 family interaction network ensures cancer resistance to apoptosis and is a major challenge to current treatments. Cancer cells commonly evade apoptosis through upregulation of the BCL-2 anti-apoptotic proteins; however, more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932091f22f92d688f32a879b08a7e4a9
https://pubmed.ncbi.nlm.nih.gov/35256598
https://pubmed.ncbi.nlm.nih.gov/35256598
Autor:
Chamini V. Karunaratne, Arne Schön, Iain A. Murray, Michelle C. Neary, Maria Maddalena Cavalluzzi, Matthew R. Redinbo, Adam P. Matson, Bret D. Wallace, Gary H. Perdew, Martina Stepankova, Ryan Balfour Sartor, Eva Jiskrová, Saraswathi Vishveshwara, Shirshendu Chatterjee, Dennis L. Wright, Zdeněk Dvořák, Haiwei Gu, Kyu Shik Mun, John C. March, Simon A. Hirota, Julia Yue Cui, Katherine Sun, Lars U. Nordstroem, Amanda P. Beck, Iveta Iveta Bartonkov, Aneta Vrzalová, Julius Brtko, Barbora Vyhlídalová, Sridhar Mani, Kyle L. Flannigan, Karolína Poulíková, Felix Kopp, Hao Li, Lucia Toporova, Harmit S. Ranhotra, William G. Walton, Cait M. Costello, Sandhya Kortagere, Aneesh Chandran, Giovanni Lentini, Anjaparavanda P. Naren, Jazmin S. Kemp
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp n/a-n/a (2020)
EMBO Molecular Medicine
EMBO Molecular Medicine
The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that established m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e9267d258ba26f43500c0c8a143511
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
Publikováno v:
Cell Chemical Biology. 23:579-586
In humans, the cytosolic sulfotransferases (SULTs) catalyze regiospecific transfer of the sulfuryl moiety (-SO3) from 3'-phosphoadenosine 5'-phosphosulfate to thousands of metabolites, including numerous signaling small molecules, and thus regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb871892c68eb1c42885a6b5c01435f7
https://doi.org/10.1016/j.chembiol.2016.04.009
https://doi.org/10.1016/j.chembiol.2016.04.009
Assessment of quantification accuracy and image quality of a full-body dual-layer spectral CT system
Autor:
Sebastian, Ehn, Thorsten, Sellerer, Daniela, Muenzel, Alexander A, Fingerle, Felix, Kopp, Manuela, Duda, Kai, Mei, Bernhard, Renger, Julia, Herzen, Julia, Dangelmaier, Benedikt J, Schwaiger, Andreas, Sauter, Isabelle, Riederer, Martin, Renz, Rickmer, Braren, Ernst J, Rummeny, Franz, Pfeiffer, Peter B, Noël
Publikováno v:
Journal of Applied Clinical Medical Physics
The performance of a recently introduced spectral computed tomography system based on a dual‐layer detector has been investigated. A semi‐anthropomorphic abdomen phantom for CT performance evaluation was imaged on the dual‐layer spectral CT at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64052db00620e0a069b585caed10e0e9
https://pubmed.ncbi.nlm.nih.gov/29266724
https://pubmed.ncbi.nlm.nih.gov/29266724
Autor:
Florence L. Marlow, Hao Jiang, Peng Wu, Aimé López-Aguilar, Lei Feng, Felix Kopp, Tianqing Zheng
Publikováno v:
Bioconjugate Chemistry
To monitor the kinetics of biological processes that take place within the minute time scale, simple and fast analytical methods are required. In this article, we present our discovery of an azide with an internal Cu(I)-chelating motif that enabled t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1ec1ae7707355d27faa4e6224e1fc6
https://doi.org/10.1021/bc400502d
https://doi.org/10.1021/bc400502d
Publikováno v:
Nature chemical biology
Macrocycles are large ring structures found in myriad natural products, and over 100 of these molecules have been developed into approved drugs1,2. Macrolactone and macrolactam structures are particularly prevalent (Fig. 1a), often derived from polyk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c729ce95abf272785d7ea9b23181df
https://doi.org/10.1038/nchembio.911
https://doi.org/10.1038/nchembio.911