Výsledky vyhledávání - "Felix Kolarov"

Binding and Proton Blockage by Amantadine Variants of the Influenza M2WT and M2S31N Explained

Autor: Timothy A. Cross, Kathrin Freudenberger, Antonios Kolocouris, Anja Hoffmann, Ioannis Stylianakis, Ian Tietjen, Felix Kolarov, Anna K. Wright, David Fedida, Christina Tzitzoglaki, Günter Gauglitz, Michaela Schmidtke

Publikováno v: J Med Chem

While aminoadamantanes are well-established inhibitors of the influenza A M2 proton channel, the mechanisms by which they are rendered ineffective against M2(S31N) are unclear. Solid state NMR, isothermal titration calorimetry, electrophysiology, ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bde8a912b66758bd58cd7aa7f928801
https://doi.org/10.1021/acs.jmedchem.6b01115

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Alchemical Free Energy Calculations and Isothermal Titration Calorimetry Measurements of Aminoadamantanes Bound to the Closed State of Influenza A/M2TM

Autor: Antonios Kolocouris, Felix Kolarov, Kathrin Freudenberger, Paraskevi Gkeka, Zoe Cournia, Christos Liolios, Harris Ioannidis, Holger Gohlke, Christina Tzitzoglaki, Günter Gauglitz, Nadine Homeyer, Antonios Drakopoulos

Publikováno v: Journal of Chemical Information and Modeling. 56:862-876

Adamantane derivatives, such as amantadine and rimantadine, have been reported to block the transmembrane domain (TM) of the M2 protein of influenza A virus (A/M2) but their clinical use has been discontinued due to evolved resistance in humans. Alth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500930f123e6ae64ba87c1e66d4f1ccd
https://doi.org/10.1021/acs.jcim.6b00079

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Interpreting Thermodynamic Profiles of Aminoadamantane Compounds Inhibiting the M2 Proton Channel of Influenza A by Free Energy Calculations

Autor: Felix Kolarov, Antonios Kolocouris, Nadine Homeyer, Harris Ioannidis, Christos Zikos, Holger Gohlke, Günter Gauglitz

Publikováno v: Journal of Chemical Information and Modeling. 56:110-126

The development of novel anti-influenza drugs is of great importance because of the capability of influenza viruses to occasionally cross interspecies barriers and to rapidly mutate. One class of anti-influenza agents, aminoadamantanes, including the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb2a992a3f2b039b381611b8280d54c
https://doi.org/10.1021/acs.jcim.5b00467

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Size does matter! Label-free detection of small molecule–protein interaction

Autor: Goran Markovic, Johannes Riedt, Julia Widmaier, Sabrina Rau, Felix Kolarov, Oliver Bleher, Melanie Ewald, Peter Fechner, Kathrin Freudenberger, Dominik Furin, Barbara Schwarz, Patricia Weber, Katrin Krieg, Urs Hilbig, Lothar Leidner, Florian Pröll, Günther Proll

Publikováno v: Analytical and Bioanalytical Chemistry. 406:4033-4051

This review is focused on methods for detecting small molecules and, in particular, the characterisation of their interaction with natural proteins (e.g. receptors, ion channels). Because there are intrinsic advantages to using label-free methods ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d0aad94645d10c02a4644c4c3fdfd2
https://doi.org/10.1007/s00216-014-7834-4

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Optical sensors with molecularly imprinted nanospheres: a promising approach for robust and label-free detection of small molecules

Autor: Klaus Niedergall, Monika Bach, Günter Gauglitz, Felix Kolarov, Günter E. M. Tovar

Publikováno v: Analytical and Bioanalytical Chemistry. 402:3245-3252

Molecularly imprinted nanospheres obtained by miniemulsion polymerization have been applied as the sensitive layer for label-free direct optical sensing of small molecules. Using these particles as the sensitive layer allowed for improving response t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7f4a4e1fe6bd4839a31a057bca885a
https://doi.org/10.1007/s00216-011-5592-0

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Prozessanalysetechnik in chemischen und biotechnologischen Prozessen: Biomimetischer Prozesssensor

Autor: Günter E. M. Tovar, Günter Gauglitz, Benjamin R. Riegger, Felix Kolarov, Thomas Hirth, Monika Bach

Ein vielseitig einsetzbares Sensorsystem für Fermentationsprozesse wie z. B. Ligninaufschluss oder fermentative Antibiotikaherstellung, das eine Konzentrationsbestimmung einer Zielsubstanz direkt ohne Probenahme, markierungsfrei und zeitaufgelöst e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f652053b695cfdd9d6379ba828b381
https://publica.fraunhofer.de/handle/publica/245826

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Eighth Advanced Study Course on Optical Chemical Sensors—ASCOS

Autor: Melanie Ewald, A. Katrin Krieg, Oliver Bleher, Sabrina Rau, Felix Kolarov

Publikováno v: Analytical and Bioanalytical Chemistry. 401:3037-3038

Aims and topics ASCOS covers the basic principles of optical sensor techniques and bioassays in modern chemical sensing together with applications and commercial aspects. Furthermore, the possibility of exchanging ideas, experience, and knowledge in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45091fe437eb77746232a334f4ab92fb
https://doi.org/10.1007/s00216-011-5391-7

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