Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Felix I.L. Clanchy"'
Autor:
Felix I.L. Clanchy, Ali S. M. Jawad, Rizgar A. Mageed, Jonas Bystrom, Richard O. Williams, Pamela Mangat, Mohammed M. Al-Bogami, Taher E. Taher
Publikováno v:
Rheumatology. 60:947-957
Objectives About half of RA patients treated with TNFα inhibitors either do not respond or lose their initial therapeutic response over time. The clinical response is measured by reduction in DAS28, which primarily reflects inflammation. However, ot
Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis
Autor:
Yi Shu Huang, Louise M. Topping, Peter Ericsson, Trevor W. Stone, Felix I.L. Clanchy, Anette Sundstedt, Wen Yi Tseng, Nien Yi Chiang, Zhong Tian Xue, Hans Olov Sjögren, Kay McNamee, Leif G. Salford, Hsi-Hsien Lin, Shue Fen Luo, Dany P. Perocheau, Joy Ogbechi, Richard O. Williams
Publikováno v:
Proc Natl Acad Sci U S A
Chronic inflammatory diseases like rheumatoid arthritis are characterized by a deficit in fully functional regulatory T cells. DNA-methylation inhibitors have previously been shown to promote regulatory T cell responses and, in the present study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea36dc466bbf5a3277448705b0da3cbd
https://doi.org/10.1073/pnas.2100939118
https://doi.org/10.1073/pnas.2100939118
Autor:
Henry Penn, Felix I.L. Clanchy, Jonas Bystrom, Federica Borghese, Trevor W. Stone, Graham Wells, Richard O. Williams, Serafim Kiriakidis, Dobrina N. Hull, Sandra Sacre, Peter C. Taylor, Attilia Balog, Lynn M. Williams, Rizgar A. Mageed
The role of the innate immune system has been established in the initiation and perpetuation of inflammatory disease, but less attention has been paid to its role in the resolution of inflammation and return to homeostasis. Toll-like receptor (TLR) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864ace76d55f477346441101dc7af267
https://doi.org/10.1016/j.jaut.2021.102597
https://doi.org/10.1016/j.jaut.2021.102597
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
The importance of the kynurenine pathway in normal immune system function has led to an appreciation of its possible contribution to autoimmune disorders such as rheumatoid arthritis. Indoleamine-2,3-dioxygenase (IDO) activity exerts a protective fun
Autor:
Louise M. Topping, Felix I.L. Clanchy, Trevor W. Stone, Joy Ogbechi, Richard O. Williams, Yi-Shu Huang
Publikováno v:
Experimental Gerontology. 131
The IDO/kynurenine pathway is now established as a major regulator of immune system function. The initial enzyme, indoleamine 2,3-dioxygenase (IDO1) is induced by IFNγ, while tryptophan-2,3-dioxygenase (TDO) is induced by corticosteroids. The pathwa
Autor:
Luo S-F., Kay McNamee, Huang Y-S., Felix I.L. Clanchy, Joy Ogbechi, Richard O. Williams, Marc Feldmann, Dany P. Perocheau, Tseng W-Y., Fiona E. McCann
Regulatory T (Treg) cells expressing the transcription factor Foxp3 play an important role in maintaining immune homeostasis. Chronic inflammation is associated with reduced Foxp3 expression, function, and loss of phenotypic stability. Previous studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6a1413289a05f4b7a5dbff55609322
https://ora.ox.ac.uk/objects/uuid:cfefd40c-1458-4c06-83ac-53f0a2af843a
https://ora.ox.ac.uk/objects/uuid:cfefd40c-1458-4c06-83ac-53f0a2af843a
Autor:
Kay McNamee, Yi-Shu Huang, Hsi-Hsien Lin, Fiona E. McCann, Felix I.L. Clanchy, Shue-Fen Luo, Richard O. Williams, Wen-Yi Tseng
Publikováno v:
Cytokine. 101:19-25
Tumour necrosis factor-α (TNF-α) is a highly pleiotropic cytokine with effects on multiple pathological and physiological functions via two distinct receptors, TNFR1 and TNFR2. Much of the pro- inflammatory action of TNF-α is mediated by TNFR1 whe
Autor:
Jonas Bystrom, Rizgar A. Mageed, Pam Mangat, Felix I.L. Clanchy, Richard O. Williams, Ali S M Jawad, Taher E. Taher
Publikováno v:
Cytokine. 101:4-13
TNFα is a principal pro-inflammatory cytokine vital for immunity to infections. However, its excessive production is involved in chronic inflammation and disease pathology in autoimmune diseases. Evidence for its pathogenic role is validated by the
Publikováno v:
eLS
The frequency of antigen-specific cells will vary during development and in response to the first and subsequent encounters with an antigen, either through infection or immunisation, and is an important indicator of adaptive immune function. Antigen-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d528a93147ec572b7c1b6ff4373657c
https://ora.ox.ac.uk/objects/uuid:8202c14f-7b3f-45cf-95cc-ed1b832bc132
https://ora.ox.ac.uk/objects/uuid:8202c14f-7b3f-45cf-95cc-ed1b832bc132
Autor:
Mike R. Dyson, John McCafferty, Alison J Cartwright, Richard O. Williams, Ilfita Sahbudin, Eric Culbert, Susan Rebecca Aungier, Brian D. Marsden, Aneesh Karatt-Vellatt, Patrick John Hextall, Anja Schwenzer, Kothai Parthiban, Felix I.L. Clanchy, Andrew Filer, Jennifer L. Marshall, Karim Raza, Christopher D. Buckley, Peter Slavny, Kim S. Midwood
Publikováno v:
Annals of the Rheumatic Diseases.
We thank the authors for their commentary1 on our article which was recently published in the Annals of Rheumatic Diseases .2 Cutolo et al write an extended discussion of the study, in which we describe the development of therapeutic monoclonal antib