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Akademický článek

Sources of variation in cell-type RNA-Seq profiles.

Autor: Johan Gustafsson, Felix Held, Jonathan L Robinson, Elias Björnson, Rebecka Jörnsten, Jens Nielsen

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0239495 (2020)

Cell-type specific gene expression profiles are needed for many computational methods operating on bulk RNA-Seq samples, such as deconvolution of cell-type fractions and digital cytometry. However, the gene expression profile of a cell type can vary

Externí odkaz: https://doaj.org/article/2a59eb2ff267438495cba19c49e154ee

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Reconstructing the regulatory programs underlying the phenotypic plasticity of neural cancers

Autor: Ida Larsson, Felix Held, Gergana Popova, Alper Koc, Rebecka Jörnsten, Sven Nelander

Nervous system cancers contain a large spectrum of transcriptional cell states, reflecting processes active during normal development, injury response and growth. However, we lack a good understanding of these states’ regulation and pharmacological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f7c5a03859665d60c78b769c21a18ad
https://doi.org/10.1101/2023.03.10.532041

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Challenge model of TNFα turnover at varying LPS and drug provocations

Autor: Felix Held, Marija Cvijovic, Johan Gabrielsson, Edmund Hoppe, Mats Jirstrand

Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics

A mechanism-based biomarker model of TNFα-response, including different external provocations of LPS challenge and test compound intervention, was developed. The model contained system properties (such as kt, kout), challenge characteristics (such a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1143dc42f639d940eba8968dc9d69c5b
http://europepmc.org/articles/PMC6529397

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Modelling of oscillatory cortisol response in horses using a Bayesian population approach for evaluation of dexamethasone suppression test protocols

Autor: Marija Cvijovic, Mats Jirstrand, Carl Ekstrand, Johan Gabrielsson, Felix Held

Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics

Cortisol is a steroid hormone relevant to immune function in horses and other species and shows a circadian rhythm. The glucocorticoid dexamethasone suppresses cortisol in horses. Pituitary pars intermedia dysfunction (PPID) is a disease in which the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89064f714a63b652ee181927b53cb3d8
https://publica.fraunhofer.de/handle/publica/258021

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Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development

Autor: Klaus Linz, Olaf Will, André Welbers, Virginia Marossek, Rolf Terlinden, Klaus Hansen, Bert Nolte, Irena Loryan, Margareta Hammarlund-Udenaes, Paul Ratcliffe, Achim Kless, Anita Wegert, Derek Saunders, Edmund Hoppe, Felix Held

Drug induced phospholipidosis (PLD) may be observed in the preclinical phase of drug development and pose strategic questions. As lysosomes have a central role in pathogenesis of PLD, assessment of lysosomal concentrations is important for understand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477e220a5faacb4b5061bcd395774bb2
https://publica.fraunhofer.de/handle/publica/253775

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