Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Felix Hausch"'
Autor:
Jakob Hartmann, Thomas Bajaj, Joy Otten, Claudia Klengel, Tim Ebert, Anne-Kathrin Gellner, Ellen Junglas, Kathrin Hafner, Elmira A. Anderzhanova, Fiona Tang, Galen Missig, Lindsay Rexrode, Daniel T. Trussell, Katelyn X. Li, Max L. Pöhlmann, Sarah Mackert, Thomas M. Geiger, Daniel E. Heinz, Roy Lardenoije, Nina Dedic, Kenneth M. McCullough, Tomasz Próchnicki, Thomas Rhomberg, Silvia Martinelli, Antony Payton, Andrew C. Robinson, Valentin Stein, Eicke Latz, William A. Carlezon, Felix Hausch, Mathias V. Schmidt, Chris Murgatroyd, Sabina Berretta, Torsten Klengel, Harry Pantazopoulos, Kerry J. Ressler, Nils C. Gassen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. Here we show that secretory autophagy (SA), a non-lytic moda
Externí odkaz:
https://doaj.org/article/83209dbad20940cdab3e3f6f4104353f
Autor:
Anna Charalampidou, Thomas Nehls, Christian Meyners, Satish Gandhesiri, Sebastian Pomplun, Bradley L. Pentelute, Frederik Lermyte, Felix Hausch
Publikováno v:
ACS Central Science, Vol 10, Iss 3, Pp 649-657 (2024)
Externí odkaz:
https://doaj.org/article/1d37f899331b430c888631986c2e4fc7
Autor:
Lena Mareczek, Lena K. Mueller, Laura Halstenberg, Thomas M. Geiger, Michael Walz, Min Zheng, Felix Hausch
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 924 (2024)
PROTACs, proteolysis targeting chimeras, are bifunctional molecules inducing protein degradation through a unique proximity-based mode of action. While offering several advantages unachievable by classical drugs, PROTACs have unfavorable physicochemi
Externí odkaz:
https://doaj.org/article/d6ee4db072db4e7e933255cf8394415a
Autor:
Patrick L. Purder, Christian Meyners, Wisely Oki Sugiarto, Jürgen Kolos, Frank Löhr, Jakob Gebel, Thomas Nehls, Volker Dötsch, Frederik Lermyte, Felix Hausch
Publikováno v:
JACS Au, Vol 3, Iss 9, Pp 2478-2486 (2023)
Externí odkaz:
https://doaj.org/article/8984322cf97846e88f94062743ef5104
Autor:
Saskia Wedel, Lisa Hahnefeld, Yannick Schreiber, Christian Namendorf, Tim Heymann, Manfred Uhr, Mathias V. Schmidt, Natasja de Bruin, Felix Hausch, Dominique Thomas, Gerd Geisslinger, Marco Sisignano
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-21 (2023)
Abstract Background Chemotherapy-induced neuropathic pain (CIPN) describes a pathological pain state that occurs dose-dependently as a side effect and can limit or even impede an effective cancer therapy. Unfortunately, current treatment possibilitie
Externí odkaz:
https://doaj.org/article/7393b95fee1a48c09212292b2adeaadf
Autor:
Ingrid Quist-Løkken, Clara Andersson-Rusch, Martin Haugrud Kastnes, Jürgen Markus Kolos, Jerome Jatzlau, Hanne Hella, Oddrun Elise Olsen, Anders Sundan, Petra Knaus, Felix Hausch, Toril Holien
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling activity. Removal of FKBP12 with drugs such as t
Externí odkaz:
https://doaj.org/article/1d7144747e7f4e01a14dd611f82ff44b
Autor:
Saskia Wedel, Praveen Mathoor, Oliver Rauh, Tim Heymann, Cosmin I. Ciotu, Dominik C. Fuhrmann, Michael J. M. Fischer, Andreas Weigert, Natasja de Bruin, Felix Hausch, Gerd Geisslinger, Marco Sisignano
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-21 (2022)
Abstract Background Neuropathic pain is experienced worldwide by patients suffering from nerve injuries, infectious or metabolic diseases or chemotherapy. However, the treatment options are still limited because of low efficacy and sometimes severe s
Externí odkaz:
https://doaj.org/article/a1ae3ff5437d4071b8e640f89f13be07
Autor:
Jorge A. Lerma Romero, Christian Meyners, Andreas Christmann, Lisa M. Reinbold, Anna Charalampidou, Felix Hausch, Harald Kolmar
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Protein dynamics have a great influence on the binding pockets of some therapeutic targets. Flexible protein binding sites can result in transient binding pocket formation which might have a negative impact on drug screening efforts. Here, we describ
Externí odkaz:
https://doaj.org/article/c24c05f623e04580bc234f8ff3bafcb8
Autor:
Emilia J. Berthold, Yue Ma-Lauer, Ashesh Chakraborty, Brigitte von Brunn, Anne Hilgendorff, Rudolf Hatz, Jürgen Behr, Felix Hausch, Claudia A. Staab-Weijnitz, Albrecht von Brunn
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
RationaleHuman coronaviruses (HCoVs) seriously affect human health by causing respiratory diseases ranging from common colds to severe acute respiratory diseases. Immunophilins, including peptidyl-prolyl isomerases of the FK506-binding protein (FKBP)
Externí odkaz:
https://doaj.org/article/2d33209544f14717b912ce86fa68e2a8
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Autor:
Silvia Martinelli, Elmira A. Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E. Heinz, Tim Ebert, Jakob Hartmann, Thomas M. Geiger, Michael Döngi, Kathrin Hafner, Max L. Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V. Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W. Turck, Mathias V. Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C. Gassen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor pro
Externí odkaz:
https://doaj.org/article/4b82f8ddb5c141baac1137b7deee6057