Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs

Autor: Carol Crowther, Charles B. de Koning, Willem A. L. van Otterlo, Kristie Bloom, Abdullah Ely, Eric B. Roesch, Marc M. Lemaitre, Samantha Barichievy, Felix H. Salazar, Patrick Arbuthnot, Marc S. Weinberg, Rafique Ul Islam, Patricia L. Marion, Justin Hean, Piet Herdewijn

Publikováno v: Artificial DNA: PNA & XNA. 1:17-26

Chronic infection with the hepatitis B virus (HBV) occurs in approximately 6% of the world's population and carriers of the virus are at risk for complicating hepatocellular carcinoma. Current treatment options have limited efficacy and chronic HBV i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c8c675cad83e41ec858888bab37080
https://doi.org/10.4161/adna.1.1.11981

Exploring gene-deleted adenoviral vectors for delivery of short hairpin RNAs and reduction of hepatitis B virus infection in mice

Autor: Felix H. Salazar, Hui Xu, Christina Rauschhuber, Anja Ehrhardt, Patricia L. Marion

Publikováno v: The Journal of Gene Medicine. 10:878-889

Background RNA interference based therapeutic approaches hold promise for the treatment of patients chronically infected with hepatitis B virus (HBV). To conquer HBV infection, long-term suppression of target transcripts in all hepatocytes without to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2938aaa92b47fc35c11fb2444ab4dd97
https://doi.org/10.1002/jgm.1207

Effective Inhibition of HBV Replication in Vivo by Anti-HBx Short Hairpin RNAs

Autor: Abdullah Ely, Sergio Carmona, Nicolas Ferry, Patricia L. Marion, Patrick Arbuthnot, Marc S. Weinberg, Felix H. Salazar, Carol Crowther, Naazneen Moolla

Publikováno v: Molecular Therapy. 13(2):411-421

Exploiting the RNA interference pathway has shown promise for developing novel and effective treatment of hepatitis B virus (HBV) infection. To advance this approach, we analyzed the antiviral efficacy of a panel of 10 Pol III U6 promoter-encoded sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402db14b82f0b3b5876872a942733b14

DODAG; a versatile new cationic lipid that mediates efficient delivery of pDNA and siRNA

Autor: Mathieu Mével, Michael R. Jorgensen, Patrick Arbuthnot, Morag H. Oliver, Andrew D. Miller, Nazila Kamaly, Patricia L. Marion, Carol Crowther, Jean-Jacques Yaouanc, Sergio Carmona, Paul-Alain Jaffrès, Masato Fujino, Felix H. Salazar, Yukikazu Natori, Maya Thanou

Publikováno v: Journal of Controlled Release
Journal of Controlled Release, Elsevier, 2010, 143 (2), pp.222-232. ⟨10.1016/j.jconrel.2009.12.001⟩
Technical University of Denmark Orbit

International audience; We report the syntheses of novel cationic lipids comprised of cholesteryl-moieties linked to guanidinium functional groups, and also cationic lipids comprising a dialkylglycylamide moiety conjugated with a polyamine or a guani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7129527937d7b0af44f576eca59c0ea4
https://hal.univ-brest.fr/hal-01577311

In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus

Autor: Jeffrey S. Glenn, John L. Casey, Kazuo Ohashi, Bruno B. Bordier, Patricia L. Marion, Leonard Meuse, Junko Ohkanda, Felix H. Salazar, Mark A. Kay, Andrew D. Hamilton, Ping Liu, Said M. Sebti, So Young Lee

Publikováno v: The Journal of clinical investigation. 112(3)

Hepatitis delta virus (HDV) can dramatically worsen liver disease in patients coinfected with hepatitis B virus (HBV). No effective medical therapy exists for HDV. The HDV envelope requires HBV surface antigen proteins provided by HBV. Once inside a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0464cd33d36018108a918a9b0aaa38f
https://pubmed.ncbi.nlm.nih.gov/12897197