Infection of Endothelial Cells with Acinetobacter baumannii Reveals Remodelling of Mitochondrial Protein Complexes

Autor: Laura Leukert, Manuela Tietgen, Felix F. Krause, Tilman G. Schultze, Dominik C. Fuhrmann, Charline Debruyne, Suzana P. Salcedo, Alexander Visekruna, llka Wittig, Stephan Göttig

Publikováno v: Microbiology Spectrum, Vol 11, Iss 3 (2023)

ABSTRACT Acinetobacter baumannii is an antibiotic-resistant, Gram-negative pathogen that causes a multitude of nosocomial infections. However, pathogenicity mechanisms and the host cell response during infection remain unclear. In this study, we dete

Externí odkaz: https://doaj.org/article/a0d6387404da467ca5711f943b78456e

Pathogenicity of Clinical OXA-48 Isolates and Impact of the OXA-48 IncL Plasmid on Virulence and Bacterial Fitness

Autor: Axel Hamprecht, Julian Sommer, Matthias Willmann, Christina Brender, Yvonne Stelzer, Felix F. Krause, Tsvetan Tsvetkov, Florian Wild, Sara Riedel-Christ, Julia Kutschenreuter, Can Imirzalioglu, Aitor Gonzaga, Ulrich Nübel, Stephan Göttig

Publikováno v: Frontiers in Microbiology, Vol 10 (2019)

OXA-48 is the most common carbapenemase in Enterobacterales in Germany and one of the most frequent carbapenemases worldwide. Several reports have associated blaOXA–48 with a virulent host phenotype. To challenge this hypothesis, 35 OXA-48-producin

Externí odkaz: https://doaj.org/article/fee07ea2757c42b2b3e6677637406f13

Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells

Autor: Aleksandra Lopez Krol, Hannah P Nehring, Felix F Krause, Anne Wempe, Hartmann Raifer, Andrea Nist, Thorsten Stiewe, Wilhelm Bertrams, Bernd Schmeck, Maik Luu, Hanna Leister, Ho‐Ryun Chung, Uta‐Maria Bauer, Till Adhikary, Alexander Visekruna

Publikováno v: EMBO reports. 23

Increased lactate levels in the tissue microenvironment are a well-known feature of chronic inflammation. However, the role of lactate in regulating T cell function remains controversial. Here, we demonstrate that extracellular lactate predominantly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a049f76bbaed8cb91cd9740cbed78366
https://doi.org/10.15252/embr.202254685

Who learns more: the impact of dual-player and single-player modes in a serious game on dental students' factual knowledge.

Autor: Krause F; Department of Operative Dentistry, Periodontology, and Preventive Dentistry, RWTH Aachen University Hospital, Aachen, Germany., Horn B; Department of Operative Dentistry, Periodontology, and Preventive Dentistry, RWTH Aachen University Hospital, Aachen, Germany., Braun A; Department of Operative Dentistry, Periodontology, and Preventive Dentistry, RWTH Aachen University Hospital, Aachen, Germany., Fedrowitz S; Audiovisual Media Center, Medical Faculty, RWTH Aachen University, Aachen, Germany., Bell L; Audiovisual Media Center, Medical Faculty, RWTH Aachen University, Aachen, Germany., Lemos M; Audiovisual Media Center, Medical Faculty, RWTH Aachen University, Aachen, Germany. mlemos@ukaachen.de.

Publikováno v: BMC medical education [BMC Med Educ] 2024 Aug 21; Vol. 24 (1), pp. 902. Date of Electronic Publication: 2024 Aug 21.

DRAC 2022: A public benchmark for diabetic retinopathy analysis on ultra-wide optical coherence tomography angiography images.

Autor: Qian B; Shanghai Belt and Road International Joint Laboratory for Intelligent Prevention and Treatment of Metabolic Disorders, Department of Computer Science and Engineering, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai 200240, China.; MOE Key Laboratory of AI, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China., Chen H; Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Hong Kong 999077, China.; Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong 999077, China., Wang X; Shanghai Belt and Road International Joint Laboratory for Intelligent Prevention and Treatment of Metabolic Disorders, Department of Computer Science and Engineering, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai 200240, China.; Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China., Guan Z; Shanghai Belt and Road International Joint Laboratory for Intelligent Prevention and Treatment of Metabolic Disorders, Department of Computer Science and Engineering, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai 200240, China., Li T; Shanghai Belt and Road International Joint Laboratory for Intelligent Prevention and Treatment of Metabolic Disorders, Department of Computer Science and Engineering, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai 200240, China.; MOE Key Laboratory of AI, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China., Jin Y; Tsinghua Medicine, Tsinghua University, Beijing 100084, China., Wu Y; Tsinghua Medicine, Tsinghua University, Beijing 100084, China., Wen Y; School of Electronic and Information Engineering, Shenzhen University, Shenzhen 518060, China., Che H; Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Hong Kong 999077, China., Kwon G; VUNO, Inc., Seoul 06536, Korea., Kim J; VUNO, Inc., Seoul 06536, Korea., Choi S; AI/DX Convergence Business Group, KT, Seongnam 13606, Korea., Shin S; AI/DX Convergence Business Group, KT, Seongnam 13606, Korea., Krause F; Johannes Kepler University Linz, Linz 4040, Austria., Unterdechler M; Johannes Kepler University Linz, Linz 4040, Austria., Hou J; School of Computer Science, Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, Shanghai 200433, China., Feng R; School of Computer Science, Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, Shanghai 200433, China.; Academy for Engineering and Technology, Fudan University, Shanghai 200433, China., Li Y; LaTIM UMR 1101, INSERM, 29609 Brest, France.; University of Western Brittany, 29238 Brest, France., El Habib Daho M; LaTIM UMR 1101, INSERM, 29609 Brest, France.; University of Western Brittany, 29238 Brest, France., Yang D; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China., Wu Q; Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China., Zhang P; Department of Computer Science and Engineering, The Ohio State University, Columbus, OH 43210, USA.; Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.; Translational Data Analytics Institute, The Ohio State University, Columbus, OH 43210, USA., Yang X; MOE Key Laboratory of AI, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China., Cai Y; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore., Tan GSW; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore., Cheung CY; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China., Jia W; Shanghai Belt and Road International Joint Laboratory for Intelligent Prevention and Treatment of Metabolic Disorders, Department of Computer Science and Engineering, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai 200240, China., Li H; Shanghai Belt and Road International Joint Laboratory for Intelligent Prevention and Treatment of Metabolic Disorders, Department of Computer Science and Engineering, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai 200240, China., Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore.; Centre for Innovation and Precision Eye Health; and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore 169857, Singapore., Wong TY; Tsinghua Medicine, Tsinghua University, Beijing 100084, China.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore.; School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Beijing 102218, China., Sheng B; Shanghai Belt and Road International Joint Laboratory for Intelligent Prevention and Treatment of Metabolic Disorders, Department of Computer Science and Engineering, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai 200240, China.; MOE Key Laboratory of AI, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Publikováno v: Patterns (New York, N.Y.) [Patterns (N Y)] 2024 Feb 08; Vol. 5 (3), pp. 100929. Date of Electronic Publication: 2024 Feb 08 (Print Publication: 2024).