Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Felix Bubeck"'
Autor:
Felix Bubeck, Dirk Grimm
Publikováno v:
PLoS Biology, Vol 22, Iss 7, p e3002637 (2024)
A new study characterizes and improves a novel small Cas12a variant before adapting it for in vivo genome editing by delivery via adeno-associated virus (AAV) vectors, showcasing the potential of small CRISPR systems and their compatibility with vira
Externí odkaz:
https://doaj.org/article/277b30738c9c4d65b9897d67e829d4d6
Autor:
Steffen Klein, Thorsten G. Müller, Dina Khalid, Vera Sonntag-Buck, Anke-Mareil Heuser, Bärbel Glass, Matthias Meurer, Ivonne Morales, Angelika Schillak, Andrew Freistaedter, Ina Ambiel, Sophie L. Winter, Liv Zimmermann, Tamara Naumoska, Felix Bubeck, Daniel Kirrmaier, Stephanie Ullrich, Isabel Barreto Miranda, Simon Anders, Dirk Grimm, Paul Schnitzler, Michael Knop, Hans-Georg Kräusslich, Viet Loan Dao Thi, Kathleen Börner, Petr Chlanda
Publikováno v:
Viruses, Vol 12, Iss 8, p 863 (2020)
Rapid large-scale testing is essential for controlling the ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The standard diagnostic pipeline for testing SARS-CoV-2 presence in patients with an ongoing infection is pre
Externí odkaz:
https://doaj.org/article/ecb4e0dd8f1f4504be4719959baa1d69
Autor:
Dirk Grimm, Ellen Wiedtke, Chiara Krämer, Emma Gerstmann, Jixin Liu, Felix Bubeck, Margarita Zayas, Joanna Szumska, Jonas Becker, Olena Maiakovska, Kleopatra Rapti
Publikováno v:
Journal of Visualized Experiments.
Gene delivery vectors derived from Adeno-associated virus (AAV) are one of the most promising tools for the treatment of genetic diseases, evidenced by encouraging clinical data and the approval of several AAV gene therapies. Two major reasons for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d49b499bcfc6eae98bab46f952222b7
https://doi.org/10.3791/64389
https://doi.org/10.3791/64389
Autor:
Daniel Heid, Dominik Niopek, Max C. Waldhauer, Irina Lehmann, Moritz Jakob Przybilla, Pauline L. Pfuderer, Roland Eils, Thore Bürgel, Catharina Gandor, Marita Klein, Mareike D. Hoffmann, Carolin Schmelas, Felix Bubeck, Julius Upmeier zu Belzen, Lukas Platz, Jan Mathony, Lukas Adam, Stefan Holderbach, Max Schwendemann, Michael Jendrusch
Publikováno v:
Nature Machine Intelligence. 1:225-235
Proteins are nature’s most versatile molecular machines. Deep neural networks trained on large protein datasets have recently been used to tackle the unmet complexity of protein sequence–function relationships. The implicit knowledge contained in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10e606d599d7c8b4e6ebd1de2fc5b7df
https://doi.org/10.1038/s42256-019-0049-9
https://doi.org/10.1038/s42256-019-0049-9
Autor:
Dirk Grimm, Felix Bubeck
Publikováno v:
Nature biomedical engineering. 5(2)
Subretinal delivery of lentiviruses bearing Cas9 mRNA and a guide RNA targeting the Vegfa gene reduces the development of choroidal neovascularization in a mouse model of wet age-related macular degeneration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931b0c15b05b7a4e0213c32efe5382f3
https://pubmed.ncbi.nlm.nih.gov/33398131
https://pubmed.ncbi.nlm.nih.gov/33398131
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2173
CRISPR labeling is a powerful technique to study the chromatin architecture in live cells. In CRISPR labeling, a catalytically dead CRISPR-Cas9 mutant is employed as programmable DNA-binding domain to recruit fluorescent proteins to selected genomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b6526b081293678d257b21d85f107d59
https://pubmed.ncbi.nlm.nih.gov/32651915
https://pubmed.ncbi.nlm.nih.gov/32651915
Autor:
Viet Loan Dao Thi, Vera Sonntag-Buck, Sophie L. Winter, Dina Khalid, Dirk Grimm, Stephanie Ullrich, Liv Zimmermann, Paul Schnitzler, Ivonne Morales, Thorsten G. Müller, Hans-Georg Kräusslich, Kathleen Börner, Steffen Klein, Bärbel Glass, Tamara Naumoska, Andrew Freistaedter, Ina Ambiel, Felix Bubeck, Daniel Kirrmaier, Michael Knop, Anke-Mareil Heuser, Petr Chlanda, Simon Anders, Isabel Barreto Miranda, Matthias Meurer, Angelika Schillak
Publikováno v:
Viruses
Volume 12
Issue 8
Viruses, Vol 12, Iss 863, p 863 (2020)
Volume 12
Issue 8
Viruses, Vol 12, Iss 863, p 863 (2020)
Rapid large-scale testing is essential for controlling the ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The standard diagnostic pipeline for testing SARS-CoV-2 presence in patients with an ongoing infection is pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79193522942b93585b0688ab80f88ef2
Publikováno v:
Methods in Molecular Biology ISBN: 9781071607541
CRISPR labeling is a powerful technique to study the chromatin architecture in live cells. In CRISPR labeling, a catalytically dead CRISPR-Cas9 mutant is employed as programmable DNA-binding domain to recruit fluorescent proteins to selected genomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f4685f86934d1ca294d1fc0d6f722cb
https://doi.org/10.1007/978-1-0716-0755-8_9
https://doi.org/10.1007/978-1-0716-0755-8_9
Autor:
Dominik Niopek, Irina Lehmann, Catharina Gandor, Pauline L. Pfuderer, Max Schwendemann, Max C. Waldhauer, Lukas Adam, Moritz Jakob Przybilla, Jan Mathony, Julius Upmeier zu Belzen, Stefan Holderbach, Mareike D. Hoffmann, Lukas Platz, Carolin Schmelas, Felix Bubeck, Marita Klein, Roland Eils, Thore Bürgel, Daniel Heid, Michael Jendrusch
Publikováno v:
Nature Machine Intelligence. 1:290-290
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d0ec784ba9e24fd0d1e1e15ba3833ee
https://doi.org/10.1038/s42256-019-0063-y
https://doi.org/10.1038/s42256-019-0063-y
Publikováno v:
Advanced Biosystems. 2:1800098
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1247986a2752d654c450e7fa6a412203
https://doi.org/10.1002/adbi.201800098
https://doi.org/10.1002/adbi.201800098