Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Felix Bochner"'
Publikováno v:
Pain Med
Pain medicine (Malden, Mass.), vol 20, iss 1
Pain medicine (Malden, Mass.), vol 20, iss 1
Objective: Acute pain management in opioid dependent persons is complicated because of tolerance and opioid-induced hyperalgesia. Very high doses of morphine are ineffective in overcoming opioid-induced hyperalgesia and providing anti-nociception to
Publikováno v:
Experimental and clinical psychopharmacology. 25(3)
Tolerance to the psychomotor impairing effects of opioid drugs is expected to develop with repeated dosing, but may be incomplete. The relationship between plasma opioid concentration and psychomotor function in opioid-dependent patients was examined
Autor:
Andrew A. Somogyi, Felix Bochner, Bruce Rounsefell, Justin L. Hay, Jason M. White, Tim J. Semple
Publikováno v:
The Journal of Pain. 10:316-322
This observational study aimed to determine whether pain sensitivity in patients with noncancer chronic pain, taking either methadone or morphine, is similar to patients maintained on methadone for dependence therapy, compared with a control group. N
Autor:
Munir Pirmohamed, Jennifer H. Martin, Albert Ferro, David Henry, Matthias Schwab, Felix Bochner, Jean Gray, Richard O. Day, Klaus Mörike
Publikováno v:
British journal of clinical pharmacology. 81(2)
Clinical pharmacology is a medical specialty whose practitioners teach, undertake research, frame policy, give information and advice about the actions and proper uses of medicines in humans and implement that knowledge in clinical practice. It invol
Autor:
Walter Ling, Peter Athanasos, Andrew A. Somogyi, Jason M. White, Felix Bochner, Charlotte S. Smith
Publikováno v:
Pain. 120:267-275
Opioid dependent patients require higher than normal doses of opioid analgesics. However, this regimen has not been formally tested. This study utilised a double-blind placebo-controlled design to examine antinociceptive responses to saline and pseud
Publikováno v:
American Journal on Addictions. 15:311-315
Methadone maintenance is associated with hyperalgesia and elevated mood disturbance-effects opposite to those induced by acute opioid administration, which may undermine outcomes during substitution therapy. This study examined the impact of switchin
Autor:
J. M. White, David J. R. Foster, Andrew A. Somogyi, Felix Bochner, Michel Eichelbaum, E. B. Morton
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 97:23-128
Publikováno v:
Addictive Disorders & Their Treatment. 3:122-128
Publikováno v:
British Journal of Clinical Pharmacology. 57:742-755
To construct a population pharmacokinetic model for methadone enantiomers in the setting of methadone maintenance treatment for opioid dependence.A population pharmacokinetic model was developed using P-Pharm software for rac-, (R)- and (S)-methadone
Publikováno v:
Drug and Alcohol Dependence. 72:85-94
Slow-release oral morphine (SROM) has been proposed as an alternative maintenance pharmacotherapy to methadone for treatment of opioid dependence. However, the pharmacodynamics and pharmacokinetics of SROM have not been previously assessed in a metha